ultimately, though you don't wanna hear it. get off the fucking tweak man.
Do whatever it takes.
Move cities, change jobs, tell your family, delete all your meth"mates" from your life, fuck it, go round your dealers place and shit on his bed so he never meets you again, whatever you need to do.
Cause the road your on, it aint pretty further down the line.
Trust me im and old fucker.
Enough of the "don't" attitude. ive said all i need, and you can take it or leave it. plus i wont judge you either way.
If you are going to be using regularly;
D-amphetamines or dexamphetamines are much much much safer. (adderal).
also...
5 golden rules
(1) Use regular d-amphetamine, instead of the more neurotoxic methamphetamine and MDA/MDMA (anything with a methylenedioxy substituent is going to produce more oxidative stress).
(2) Keep your dosage reasonable--don't use massive tweak-a-thon binge doses. Also, always take your amphetamines orally as they were meant to be taken, that way you get a nice, smooth stimulation without a sudden massive jump in plasma concentration.
(3) Ensure that your core body temperature stays as low as possible--neurotoxicity is directly linked to hyperthermia, so chill out (literally). You can use a little paracetamol (a little) with a NSAID to lower a fever if it occurs.
(4) For anti-oxidant supplements, try Vitamins C, D and E, as well as resveratrol. Levo-deprenyl is also good, but keep your dose low if you are taking it with amphetamine. Ergoloids like hydergine work too.
(5) Throw in a little magnesium to lower amphetamine tolerance.
best antioxidant is green tea!!!! lots of it!!
body temp in summer is an issue!! use your air con! its worth the money!! a little known secret, but mine was always pumping, as a cool body -even by point 9 of a degree - is one FAR less succeptable to neurotoxicity! in fact the effects in rats are startling - two groups recieving daily amps, one at 23C and one at 26C, just 3 degrees, showed a huge reduction on neurotoxicity!
Oxidative stress btw is -
In a nutshell, oxidative stress is produced by oxygenated free radicals such as superoxides, peroxides and hydroxides that cause intracellular and extracellular damage and eventually induce cell apoptosis (death). These oxidants are produced normally by the body during its daily functioning and are usually easily dealt with. However, drugs like methamphetamine increase body temperature by serotonin efflux, which reduces the ability of a cell to cope with oxidative stress, as well as increase free radical formation by dopamine efflux. Dopamine is metabolized to its aldehyde by MAO-B resulting in the formation of ammonia and hydrogen peroxide, which can further lead to the formation of other radicals like superoxides in a pro-oxidative environment such as one with increased temperature.
This is why MAO-B inhibition protects against neurotoxicity induced by methamphetamine and the like, and why those drugs are so dangerous to the brain. It's also why antioxidants provide protection against such damage.
i used to do something like this -
2x400mg Magnesium Oxide
1x100mg CoQ-10
2x500mg Taurine
1x B-Complex Vitamin
1x100mg 5-HTP
2x10mg Vinpocetine
1x100mg DMAE
1x500mg L-Tyrosine
2x350mg Choline
1x Omega-3 "950"
1x200mg Alpha Lipoic Acid
2x Glucosamine Chondroitin MSM
^ideal effective prevention from NTXY
protein shakes are good - essential amino acids
green tea too
with regards to vitamin C be sure you take it only after your amps wear off because it interferes with absorption and speeds up the excretion of amphetamines.
sleeping is crucial
Generally, I would recommend not going above 100mg of regular amphetamine in 24 hours. For methamphetamine, the dose would be lower, as methamphetamine releases almost 5-times the amount of dopamine that amphetamine does in DAT-expressing cells (Goodwin et al, 2009). Meth appears to be a whole new can of worms when it comes to addictiveness and toxicity...but it is hard to know if that is a result of the pharmacology of the compound itself (compared to regular amphetamine) or the ridiculously high doses that recreational users and addicts tend to administer. It seems that people who take meth usually take upwards of 100mg per dose (often taking more than one dose per day)--for those that administer it by smoking, a dose of 250mg per sitting is considered fairly routine. Clearly, mg for mg, methamphetamine is more toxic and far more addictive than regular amphetamine, but the fact that it seems to be used almost exclusively in over-the-top doses can't help matters.
Also, for tolerance sake, taking a low dose of amphetamine consistently is far better than taking a large dose (and I would say 150mg is definitely a large dose) sporadically. Sporadic high-dose amphetamine (and especially methamphetamine) administration seems to dramatically increase tolerance to the beneficial effects--cognitive enhancement, wakefulness, mood elevation--while paradoxically decreasing tolerance (or sensitizing, as it is called in the animal literature) to the negative effects--peripheral tweakiness, compulsive/stereotyped thoughts or motor behavior, insomnia, mania, etc... Consistent administration of low-dose amphetamine tends to exert the opposite effect: tolerance to the annoying peripheral effects but preservation of the cognitive benefits and central stimulation.
thats enuff for now
