When does tolerance litteraly happen ?

[redfurkk]

When (t=x + t0 in hours) does tolerance (downregulation of 5-HT receptors) happen for phenytylamines (Mescaline, 2Cs...) ?

 

[redfurkk]

I am asking for swim to be able to better estimate redosing effect/dose in relationship with time
^_^

 

[morphine-dreams]

Based on my experiences, redosing on the same day/trip is fairly useless. I can trip harder if I want, but it takes a significantly larger amount of said drug (I'm only experienced with mescaline though, not any RC phens-yet). The next day my tolerance is generally lower although still there. After about a week or so I seem to be back, or at least very close to, baseline. It kind of sucks because I can't stagger my doses with psychedelics like I can with dissos, so I always have to get the initial dose right. If I want to intensify my experience, I find that weed helps a lot, but not everyone likes weed with psychedelics. Like with everything else though, I'm sure it differs from person to person. My bf can redose psychedelics on the same day and trip just as hard, but I also use them more frequently so I probably always have some level of tolerance. My tolerance has never quite dropped to where it was when I first started using psychedelics but it's still pretty low as long as I wait a day or two between trips.

 

[morphine-dreams]

So to answer your question more concisely, about t+1 or 2 hours. Basically, once I come up.

 

[InterestingFACT]

Tolerance doesn't suddenly onset, it's a function of effect over time. Obviously, before you "come up" (ie. before the drug has reached your receptors in sufficient concentration to cause an effect) you are not accruing tolerance. However, tolerance is accruing from the come up to the comedown. Any additional drug quantity taken after the initial quantity will be subject to tolerance, but the degree of tolerance will be dependent on the area under the curve of drug concentration/time. Keeping in mind that an orally taken drug will take some 15 to 45 minutes to onset, speaking in practical terms, any redose after the trip begins will be subject to diminishing returns, but most especially any redose taken after the *peak* of the trip will be mostly ineffective except to prolong the aftereffects, whereas a redose before the peak might prolong the peak effects or slightly increase the peak effects, depending on timing.

 

[MSK]

With phens and tryptamines I feel the better is to take one enough dose, not redose, and never take them two days on a row, or more than once a week. If you want a really long experience, take some DOx or LSD, if you want less headfuck and good duration, take 2C-x, if you want a short one, take a tryptamine. Adjust dosage to desired intensity, and here we go! Redosing or binging on psychedelics doesn't really worth it for me.