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What's the most potent 25-I molecule ?

No clue but I'd guess 25B. I don't think 25E or DOET are as potent as you'd imagine, but my memory is fuzzy about that.
 
pubmed.ncbi.nlm.nih.gov

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs) - PubMed

The binding profile of NBOMe drugs predicts strong hallucinogenic effects, similar to LSD, but possibly more stimulant properties because of α1 receptor interactions.
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

This paper looks at the binding affinities (and activation concentations) of various 2CX compounds and the NBOMe varients.

They find 25B-NBOMe is the most potent (binding affinity of 0.0005 uM) followed by 25I-NBOMe, 25E-NBOMe, and 25T4-NBOMe (all with a binding affinity of 0.0006 uM).
 
Thanks. You see what I'm trying to do is design a 5HT-2a super agonist, but I'm only going by what already exists.
 
MedicinalUser247 said:
Thanks. You see what I'm trying to do is design a 5HT-2a super agonist, but I'm only going by what already exists.
Click to expand...
Why? The 25X compounds are some of the worst and most dangerous psychadelics. Other super potent agonists like bromo dragonfly are just as problematic.

As a counterexample mescaline is a truly weak compound, and it is lovely.
 
Great point. What there needs to be is a reduction of the stimulating part of the structure. How to go about that I'm still not sure.
 
Basically the propan-2-amine. Thats why I going to replace everything I design with a propane-1,2-diol to make it safer.
 
But why does that cause stimulation? Like what is happening in the nervous system and to muscles and other organs such as the heart and why do those things happen?
 
You seem awful sure that particular part of the structure is doing what you think it is, but you don't understand how?

How do the chemical properties of that structure impact the volume of distribution, what tissues does it end up in at the highest concentrations?

Which part of that structure is responsible for DAT and NET binding? How can you figure that out?
 
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Thanks that's the best summarizing slideshow ever! Is norepinephrine release or reuptake inhibition what makes mdma, coke and meth speedy?
 
Both dopamine and norepinephrine can be stimulating. NE generally is associated with activation of the sympathetic nervous system which causes things like the increase in heart rate and blood pressure but dopamine can cause changes in the striatum to cause a person to physically move more. Too much NE release has also bee associated with muscle tremors. Its pretty complicated and there are multiple systems that you need to look at depending on what type of "stimulation" you're interested in
 
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