Absolutely. Each to their own has always been my moto. As someone with a younger sib who was born biologically female but began identifying as male from a relatively young age, I was forced to adapt my way of thinking from quite a young age myself. In many respects i'm grateful for it. It's opened my mind quite considerably.
Gay people and transgender people are generally some of the kindest people you can meet and true loyal friends (not always, but most of the time). I don't particularly like gay people who always feel like they need to be in my face about it however, but those that simply accept who they are and who I am and don't feel the need to be all politically correct about everything can be great social company. Even my longest term best friend is a gay female and I'm so lucky and grateful to have her as part of my life. We both mock each other all the time for a wide variety of reasons, but never get salty with each other over it. Those are the best friendships I think.