I'll never forget my quickest come up. It was the fourth or fifth time I tried E and it was on gel caps that my friend laughingly told me were so strong that they'd shoot you to the moon.
I took one on an empty stomach and within about 12 minutes was rocketing to the peak. I was terrified and totally freaked out. We were at my apartment on our way to a club, and my friends had to almost drag me to the car, open the door, put on my seatbelt. I was so overwhelmed I thought I was going crazy and would remain that way for the rest of my life.
The panic only lasted about 2 minutes and then melted away. I have never in my entire 5 years of using E been so high. I would suddenly open my mouth and random verbal diahrrea would just spew out as there was free thought/word associations. Walking on the sidewalk from the car to the club, my feet felt so amazing in my runners that I almost cried. It was at night and the lights all vibrated back and forth; the eye wobbles were incredible. When we entered the club the music that was playing imprinted on my mind and to this day gives me a huge and wonderful flashback.
The negative effect was that until then I never was afraid to drop pills, but it was so intensely overwhelming that from that day on I developed an anxiety about dropping pills because I was so scared of coming up, and that was the day that I never really quite rolled the same again. Come ups went from generally very fast to long, slow drawn out anxious affairs.