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  • BDD Moderators: Keif’ Richards

What SSRI/SNRI has worked best for you?

I still have that firm belief that SSRI's are no good for anxiety, simply because anxiety is mainly a GABA problem.

I too have ruled out all SSRI's for anxiety, they are just no good for anyone who is looking for a REAL productive aid in treatment.

They make this FAKE wall of happiness one day, then you can't laugh at the funniest joke in the world the next.
 
Psychedelic Jay said:
I still have that firm belief that SSRI's are no good for anxiety, simply because anxiety is mainly a GABA problem.

I too have ruled out all SSRI's for anxiety, they are just no good for anyone who is looking for a REAL productive aid in treatment.

They make this FAKE wall of happiness one day, then you can't laugh at the funniest joke in the world the next.
Click to expand...

Anxiety is mostly a psychological reaction towards awkward situations and unconscious fears. You cannot justify anxiety purely on GABAa receptor agonism.
Surely GABAa are very helpfull in inhibiting the symptoms of anxiety and panic attacks, but the main process which triggers anxiety comes from within you psychology.
It' is superficial to blame anxiety exclusively on GABA disequilibrium, the brain isn't simply a organic machine, if you take psychology for grated than you cannot understand the psychological processes leading to anxiety.
 
I was referring to GABA deficiency. And GABAa receptors are only half of the story. GABAb receptors are also linked into this as well.
GABA effects more than just the psychological aspects of anxiety.

I was not talking about agonizing, but to stop your body from destroying what is already there.
Tiagabine(GABA re-uptake inhibitor) has been shown to have the effectiveness of a benzo (physical and psychological), with no addiction potential.

I was merely talking to the morbidly stressed out individuals who are getting SSRI's as a treatment for anxiety. This is a bunch of bullocks.

The key is: if one gets happy his anxiety is greatly diminished. But, the problem with SSRI's, is that they DO NOT get rid of the physical manifestations of anxiety, which is linked to a GABA deficiency and over-stimulation of adrenaline, not serotonin.

It is true that anxiety exist in depression, but not all depression exist in anxiety.
That's all I'm saying.

SSRI's should not be for non-depressed anxious people.
 
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taking effexor.75mg. might start taking more. been taking it for about 2 months. no side effects. like it. i just drink alot of alcohol with it which i hear isnt good.
 
no SSRI/SNRI is going to "Work" if youre looking for happiness in a pill.. period.
 
This should be a poll.

I've tried Lexapro, Luvox (fluvoxamine) and Wellbutrin. So far I've found the nicest regimen to be 150 mg WB XL combined with 5-10 mg Lexapro. The combo seems to have relieved most of my depressive and anxiety symptoms while still leaving me lucid.

I tried a run of Lex on a high dose of 30 mg, and it completely eliminated all depression and anxiety, but it also made me some sort of depersonalized zombie.
 
dragonslayer428 said:
I found effexor to be too stimulating. It was pretty good for depression, but wasn't good for my anxiety. I've ruled out all SNRI's.
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I found the exact opposite. My social anxiety went away entirely, but I had some of my worst depression ever. Let's just say I now have a scar to remind me to never take an SSRI/SNRI again.
 
Zoloft

Okay, to give some background information without boring you too much, I'm currently diagnosed with Chronic PTSD, Major Depression, Obsessive Compulsive Disorder, & nearly every Anxiety disorder [my anxiety problems are usually so bad that my newest doctor's thinking of changing my Social Anxiety diagnosis to Social Phobia].

SNRIs in general just make me uncomfortable, because new medications make me uncomfortable, I believe the only SNRI I've taken via prescription was Cymbalta, & I got so sick from that stuff that I had to go to the hospital for some sort of incredibly severe dehydration. Plus it made me really irritable & anxious & pissed off & basically put me in the mood it was supposed to take me out of. Also, most mental health professionals I've talked to aren't very big fans of SNRIs either.

As far as SSRIs go, I've been on & off [mostly on] Zoloft for almost a decade now. My current dose is 150mg a day, but it's obviously varied over the years. Zoloft REALLY, REALLY did help me A LOT. It took me a long time to see just how much it helped me, but it really did. Plus it did a LOT to control my OCD, which I wasn't even diagnosed with at the time but looking back on it I guess that's one way in which I just got lucky with the right medication first.

Other SSRIs I've tried are the usual suspects: Prozac & Lexapro.

Prozac made me manic as fucking hell. I know it's a great medication for some people, but for me... God, if I had stayed on that stuff for more than a few months I'd probably be dead or in jail by now.

Lexapro didn't really do a goddamn thing for me, except make me slightly more depressed & anxious.
 
BTW I'm on my 2nd months of 225mg effexor XR and i have to say i havent fel any side effects apart from a slight decrease in libido and some digestive problems.
This is a bit embarrassing ....but I literally poop 'balls'.
 
yea, i've tried prozac, cymbalta, celexa and lexapro. they all didn't really work for my depression, but lexapro was the best one to work on my anxiety. i haven't suffered a panic attack yet on it.
 
PROBLEM WITH HOW ANTIDEPRESSANTS ARE PRESCRIBED:

Major Depression from 2006 (age 14)
Suicidal thoughts/actions, insomnia, accesive crying, ill mood for no apparent reason....etc.

1st step (late 2006): General Councelor/therapist: she heard my story, whipped out this booklet and asked questions and from there determined I was clinically depressed. Referred me to a family doctor who then asked the same questions and prescribed an SSRI: Zoloft/Sertraline 100 mg.

Zoloft/Sertraline: First few months I was getting a kick out of it... believed it was working... it was alright. After about 6 months started feeling like a Zombie... no happy, no sad, just....there. So in my opinion--great for ppl with big mood swings... but other than that is was zombie-ish. Decrease in sex drive as well. Weened off with 50mg then stopped. (During this period of time I am still seeing a therapist and believing that I am clinically depressed).

2nd Step (end of 2007): Family doctor referred me to a psychiatrist... totally weird lady but I went with it...she's a professional, right? I'm about 15 years old at this point, with all these doctors telling me that meds are the way to go and that my situation needed them. She asks me the same questions i've been asked about 2 times already then throws some random ass ones in like "spell WORLD backwards". She then prescribed me Cymbalta 60 mg as she thinks my depression is more than Serotonin issue but also a norepinephrine issue as well.

Cymbalta: Ultra-mega-ZOMBIE pill. Significant decrease in sexdrive. Seemed to give me more energy (mentally)...yet only energy to think even more depressing, suicidal thoughts. At the same time as giving me energy mentally, it made me want to sleep all the time. Horrible experience.

Was on this shit for about a little over a year.. and started weening myself off by visually emptying the capsules gradually per 2 week/week/half week/day... HORRIBLE withdrawls... brain zaps, intestinal issues, extreme depression....etc. Once I was off of it life seemed to have opened a door to happiness.

I have a big problem with how doctors are prescribing antidepressants these days and I feel like its only going to get worse with this new Health Care Plan.... SOMEONE MUST DO SOMETHING about this.... like better evaluating patients instead of just asking them 10 questions and then giving you pills. Especially to adolescents who will almost believe anything you tell them if you are a professional.
Maybe they can start scanning the brain somehow, test the levels of neurotransmitters...etc. Just something new....

AMEN.
 
been on snri,s for about 8 years venfaxoline now duxoline sort of the same drug action also
 
I've been through a bunch of antidepressants until I found 1 that seems to be doing ok with the depression part, but not so much on the anxiety front.

I've been through trazodone (Desyrel), bupropion (Wellbutrin), paroxetine (Paxil), fluoxetine (Prozac), and citalopram (Celexa) - none of which worked.

I'm seeing some positive results from escitalopram (Cipralex, Lexapro) right now, but it's still a bit too soon to say. I haven't seen any anxiety relief from it, but it seems like it's slowly lifting up my depression.
 
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