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  • BDD Moderators: Keif’ Richards

What SSRI/SNRI has worked best for you?

I've completely off SSRI's now, and have been for a few months. They just didn't work that well for me. I'm now on bupropion (a DNRI) and it seems be to helping with my depression/suicidal thinking, and also my cravings for meth.
 
Sweet P said:
I've completely off SSRI's now, and have been for a few months. They just didn't work that well for me. I'm now on bupropion (a DNRI) and it seems be to helping with my depression/suicidal thinking, and also my cravings for meth.
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Burpropion is a very good anti depressant for meth recovering people since it's a dopamine noradrenaline reuptake inhibitor.
As u might already know the blast of meth comes from the dopamine, epinephrine storm in the brain and to a lesser extent also a high serotonin release.

I would advice to take some 5-HTP suplement with that. And try taking melatonin before goiin to sleep, that thing does wonders on your sleep mechanism and it wors also as a good antioxidant.

Good luck 'Sweetie'
 
/navarone/ said:
Burpropion is a very good anti depressant for meth recovering people since it's a dopamine noradrenaline reuptake inhibitor.
As u might already know the blast of meth comes from the dopamine, epinephrine storm in the brain and to a lesser extent also a high serotonin release.

I would advice to take some 5-HTP suplement with that. And try taking melatonin before goiin to sleep, that thing does wonders on your sleep mechanism and it wors also as a good antioxidant.

Good luck 'Sweetie'
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Thanks. Yep, I knew all about bupropion and its effects on dopamine and norepinephrine - the same chemicals which meth primarily works on. That's why I specifically asked my doc for that medication. I researched it well. :)

I'm a chronic insomniac and have huge trouble falling asleep. I've tried melatonin in the past but it's effects were pretty minimal. I'm now on 100mg's of Seroquel (an anti-psychotic and major tranquiliser) each night for sleep.
 
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BTW my effexor treatment is working good so far, im on my 3rd week 150mg daily and so far no side effects. Also as an ex meth/amphetamine addict I decided to moderately take 50 mg of L-DOPA and Carbidopa 2-3 times a day to help with my motivation, apathy and emotional reward disorder (thats very common in amphetamine users).

However Effexor hasn't really gotten me out of my depression since I have a catastrophic load of problems going on in my life and surely no pill is going to fix that, I'll have to deal with it by myself but the good thing is that it stopped my desperation episodes and my feelings of hopelesness, and catatonic lethargy.

So far I'm content, maybe I'll try Paxil someday but luckily this drug has helped me a lil bit.

Cheers
 
/navarone/ said:
Also as an ex meth/amphetamine addict I decided to moderately take 50 mg of L-DOPA and Carbidopa 2-3 times a day to help with my motivation, apathy and emotional reward disorder (thats very common in amphetamine users).
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Interesting... I might look into those. I'm suffering from post acute withdrawals - anhedonia, apathy, lack of motivation, poor concentration and memory, and so on. If I can find something to help with those, it would make life a lot easier. Do you think it would be safe taking L-DOPA in conjunction with bupropion?
 
Hey man i read your post, im kind of in a simular situation, but after being on 4 or 5 dif ones over long periods of time, i cannoot live wit the side effects of them.. the sex drive being 100% completely LOST is definately something i cant deal with, and ive tried welbtrin, it does the same thing. im 22, and ive got a couple dif docs saying i would seriously benefit from taking an SSRI/SNRI but ive yet to give in.

In your experience, if you can remember, which of the meds you took Did most harm to your sex drive ? Which ones were better for it ?
 
The anorgasmia is a serious obstacle for SSRI therapy for me. Prozac was the worse. Lexapro and zoloft were prety much just as bad. If fact I am convinced that they might have a long term adverse effect on organsm- it feels hollow somehow. Wellbutrin was the best, bust made me sweat too much and made me alittle nervous. Helped overcome SSRI induced anaorgasmia alittle bit. Really amphetamines are the drugs that seem to enhance orgasm if one could use them for depression (get Rx)- but sometimes they have the oposite effect.

Suboxone has helped my depression alot and it doesn't have that pronounced effect on my sex drive suprisingly- atleast in doses less than12 mg. Xanax seems to improve depresssion for me (and of course cripling panic attacks)- SSRI's- I think the cure is worse than the disease.

Anybody know any tricks for hyperhydrosis caused by alot of these drugs (increased sweating). Trued robinul in past. Heard botux is the currebt treatment of choice.
 
BTW in this thread in Advanced Drug Discussion a few people recomended me a interesting drug.
Priribedil (Trivastal) used primarly to treat parkinson but it is also indicated for:

- Treatment of pathological cognitive deficits in the elderly (impaired attention, motivation, memory, etc).

- Anhedonia and treatment-resistant depression in unipolar and bipolar depressives

Seems also to have very few side effects.
 
^Interesting.

Wellbutrin (not an SSRI, it's a DARI) has easily been the most effective antidepressant I have ever taken. It made me a little jittery but I was on a sustained Klonopin regimen at the time, which put a dent in it. I'm referring to the SR formulation. I was happy... and constantly HORNY. The guy I was dating at the time was happy to have his girlfriend back in more ways than one.

Wellbutrin IR is about on par with taking ephedra in me. It is a totally different drug in the IR formulation in vivo to me and I will never put it in my body again. I eagerly await the patent expiring on SR.

Paxil - random crying spell on Day 2 that gave me my first-ever suicidal thoughts. Discontinued on Day 3 per doc's orders.

Zoloft - uncontrollable nausea and headache, discontinued on Day 2 IIRC.

Tramadol - Also effective but with the side effect that it gets me high as a kite at low doses. Pins and needles with rapid taper but that's it.

Lexapro - I am prescribed this now but had to get clean of tramadol before I can consider taking it. With my track record I am hesitant as anything but since it seems to work for so many of you with similar diagnoses to me, I may very well give it a go. I am just scared of the side effects as I do not think my problem is with serotonin. The disease may be preferable to the cure but I think I'd be doing myself a disservice if I didn't at least try it.

My diagnoses are panic disorder (mildly agoraphobic), GAD, and major depressive disorder. I take Valium daily (usually 5 mg but I am allowed 30 8o) and Xanax PRN.

And I want Adderall for my depression!!! I have to rule a few more things out but I think that is what will eventually happen. My shrink isn't afraid of prescribing off-label, which is great - but I think raising the issue at the moment might be pushing it. Better that my panic disorder is stabilized and that I'm not on 3 addictive prescriptions at once. 8)
 
My new psych has upped my effexor dose to 225mg a day but apart from that he has actually prescribed me a bunchload of supplements like omega3 gelcaps, phophatidiserine tablets, B vitamins ect.. to improve my mental conditions and to 'heal' the damage done by drugs and stress.
I must admit that i find that weirdly admirable from a psychiatrist.
 
Mariposa said:
^Interesting.

Wellbutrin (not an SSRI, it's a DARI) has easily been the most effective antidepressant I have ever taken. It made me a little jittery but I was on a sustained Klonopin regimen at the time, which put a dent in it. I'm referring to the SR formulation. I was happy... and constantly HORNY. The guy I was dating at the time was happy to have his girlfriend back in more ways than one.

Wellbutrin IR is about on par with taking ephedra in me. It is a totally different drug in the IR formulation in vivo to me and I will never put it in my body again. I eagerly await the patent expiring on SR.

Paxil - random crying spell on Day 2 that gave me my first-ever suicidal thoughts. Discontinued on Day 3 per doc's orders.

Zoloft - uncontrollable nausea and headache, discontinued on Day 2 IIRC.

Tramadol - Also effective but with the side effect that it gets me high as a kite at low doses. Pins and needles with rapid taper but that's it.

Lexapro - I am prescribed this now but had to get clean of tramadol before I can consider taking it. With my track record I am hesitant as anything but since it seems to work for so many of you with similar diagnoses to me, I may very well give it a go. I am just scared of the side effects as I do not think my problem is with serotonin. The disease may be preferable to the cure but I think I'd be doing myself a disservice if I didn't at least try it.

My diagnoses are panic disorder (mildly agoraphobic), GAD, and major depressive disorder. I take Valium daily (usually 5 mg but I am allowed 30 8o) and Xanax PRN.

And I want Adderall for my depression!!! I have to rule a few more things out but I think that is what will eventually happen. My shrink isn't afraid of prescribing off-label, which is great - but I think raising the issue at the moment might be pushing it. Better that my panic disorder is stabilized and that I'm not on 3 addictive prescriptions at once. 8)
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I believe Lexapro is the american version of Cipralex, it has done very little for me. I find that it bring out my anger easier and other disgusting side effects. I can't wait to be off of it! Blah! I hear alot of people say it worked for them too, but for me it seems to be doing more harm than good. I hope it works for you though, as each person is different. :)

Oh and the sexual side effects suck ass.
 
I have just started SSRI's in October 2009 and none seem to be working. Quetepine (Siroquel), Cipralex and Clonazepam combo made me lose 20Lbs. Now I am only on Cipralex 20mg and Clonazepam 0.5mg (three times daily) and it's doing nothing. I miss a dose even by 10 minutes and I have a severe headache/migrane.

Though I was taking Amotryptoline (self medicated) and it was helping but it was also causing bad side effects once the medication started to wear off. I was sloppy and my memory was shit, talked in my sleep and had very lucid dreams. Though I like the lucid dream part the lack of hunger and stumbling around was not my cup of tea.
 
^ Yeah, you've gotta be careful with tricyclic anti-depressants like Amitriptyline. They tend to have more drug interactions and worse side effects than newer anti-depressants like SSRI's. My doctor refused to prescribe tricyclics to me because they are one of the few anti-depressants that you can fatally overdose on. :\
 
I've just started my Piribedil treatment 2 20mg pills (one in the morning and one at noon), and I have to say that I can somehow already feel a positive difference, this thing its pretty fast acting but i'll have to wait a fw more days to achieve proper results.

Keep ya updated.

Ciao
 
Congrats /navarone/ on feeling better! I know sometimes it can take a lot of trial and error to find the right med combination.

I'm feeling much better on Lexapro, which I started about 24 days ago. The atarax that my Dr. gave me does absolutely nothing for me. Even when I take it with my clonazepam, it makes no difference.

I used to be on Neurontin and may ask my new dr. about going back on that. It really helped as a mood elevator. Or possibly Lyrica?

Has anyone had any positive experience from Lyrica for anxiety?
 
I've tried Prozac, Effexor XR, Zoloft and Wellbutrin XL.

I'd say Zoloft worked best for my symptoms however it took a very long time to kick in and it made me gain a ton of weight even though I was exercising daily and eating a healthy diet.

Prozac always made me wanna puke. It also made me really sensitive to light.

Effexor XR zombified me like a motherfucker. I couldn't eat anything and I couldn't sleep either.

Wellbutrin XL made me feel constantly agitated and on edge.
 
I'm starting to get dissappointed in effexor.

At the beginning when i took 75-150 xr it prevented me brom having brakedowns, now that i'm on 250 xr it hasn't improved much.....feel pretty flat, not sad but hmm dunno.
Also the piribidil wasn't such o a deal afterall.
 
I found effexor to be too stimulating. It was pretty good for depression, but wasn't good for my anxiety. I've ruled out all SNRI's.
 
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