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What pychedellic drugs are easiest on the stomach?

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getcolor728

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Oct 23, 2025
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I have gastroparesis which pychedellic substances are easiest on the stomach or less likely to cause sttomach pain or nausea? Is there a way to lessen nausea and pain associated with pych usage?
 
getcolor728 said:
I have gastroparesis which pychedellic substances are easiest on the stomach or less likely to cause sttomach pain or nausea? Is there a way to lessen nausea and pain associated with pych usage?
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Taking any psychedelic with that disorder may be tricky. All psychs can cause nausea and vomiting but i found acid to cause less then shrooms
 
Just guessing but probably LSD, natural psychedelics may cause nausea or stomach pain, gas and vomiting
 
Hey there, I´m gonna move this over to the Psychedelic forums as that is where I think it belongs.

In general, LSD has always been easier on my stomach than Mushrooms. Ayahuasca seems to nearly guarantee nausea, Mescaline is known to produce nausea so LSD would be probably your best bet.
 
echoing the lsd shouts - only from personal experience though so very subjective - but have never noticed any stomach discomfort at all from lsd (probably around 35 trips )
 
Psychedelics activate 5-HT2A receptors, and in the gut, activating these receptors tends to stimulate activity. The results are highly variable between different people, different substances, and even different trips with the same person and substance. I tend to agree that LSD is a bit less likely to cause discomfort than most other psychedelics, but it does still happen. I've personally had nausea and some gut discomfort on a fairly modest LSD, despite the fact that I handle drugs like mescaline and 2C-E (more notorious for causing nausea) quite well.

It's hard to say how your body will react to any particular psychedelic, especially without knowing more about your health condition and its root causes. I would suggest being cautious with whatever you decide to do and start with very low doses to see what happens. I actually suffered for many years from GI discomfort which was attributed to IBS. These symptom developed during a time in which I was using psychedelics regularly but were likely caused by my diet and by other (pharma) drugs I was taking at the time. Then I quit psychedelics for 11 years (!), and over that period, I worked out how to eat better to limit the severity of my gut symptoms. Nevertheless, they persisted and were very uncomfortable until I started taking psychedelics again. Then, after having taken a very low dose of 2C-D, I experienced almost complete remission of said symptoms, and with additional doses (mostly quite low), my guts seemed to progressively heal. Now I am essentially symptom free as long as I stick to my diet. The improvement was very dramatic.

If you do experiment with psychedelics, don't just pay attention to the short-term. You may indeed feel quite a bit worse on the day you take them. For me, the improvements came within a few days or so. It feels a bit like psychedelic "reset" my GI system, and that things get better after a waiting period for things to normalize.

Good luck!
 
i'm looking up gastroparesis and it sounds like extreme constipation.

i've heard it before, and i read a lot on the LSD reddit, and it happens to me, lsd causes extreme bowel movements... i would think this wouldn't be a problem for you, but i noticed i get constipated the day after LSD.. i'm not sure if it could upset your stomach or digestive track... i'd say ask your doctor about it, but i'm not even sure if they know.. i only looked up your condition for like 2 seconds, so i really have no idea, i just wanted to tell you that LSD causes me to shit a lot while peaking on it and then a day later i get constipated.. i've tested this a lot, i will definitely be constipated the day after LSD no matter what or how much i eat.

i just googled about lsd and serotonin which i hear a lot about on reddit, i don't know, it can definitely change the gut temporarily, not sure how though "How does LSD affect the gut? By changing the composition of the gut microbiota, psychedelics can modulate the availability of microbial substrates or enzymes (e.g. tryptophan metabolites) that, interacting with the host via the gut-brain axis, can modulate psychopathology." maybe you might want to try to figure out if that would affect your condition. idk. sorry, if i have no idea what i'm talking about.. i just keep seeing people recommend LSD and wanted to share my experieince.. i've also heard about people shitting blood when taking tremendous amounts of LSD that you would probably never take. read about it on the overdose section of wickepedia just seems like it has potential to mess with the gut. EDIT: accidently wrote "the overdose section of reddit" if anybody cought that before i edited it... the Overdose section of wickepedia mentions people shitting blood on tremendously high doses.
 
foodcrisis said:
i'm looking up gastroparesis and it sounds like extreme constipation.

i've heard it before, and i read a lot on the LSD reddit, and it happens to me, lsd causes extreme bowel movements... i would think this wouldn't be a problem for you, but i noticed i get constipated the day after LSD.. i'm not sure if it could upset your stomach or digestive track... i'd say ask your doctor about it, but i'm not even sure if they know.. i only looked up your condition for like 2 seconds, so i really have no idea, i just wanted to tell you that LSD causes me to shit a lot while peaking on it and then a day later i get constipated.. i've tested this a lot, i will definitely be constipated the day after LSD no matter what or how much i eat.

i just googled about lsd and serotonin which i hear a lot about on reddit, i don't know, it can definitely change the gut temporarily, not sure how though "How does LSD affect the gut? By changing the composition of the gut microbiota, psychedelics can modulate the availability of microbial substrates or enzymes (e.g. tryptophan metabolites) that, interacting with the host via the gut-brain axis, can modulate psychopathology." maybe you might want to try to figure out if that would affect your condition. idk. sorry, if i have no idea what i'm talking about.. i just keep seeing people recommend LSD and wanted to share my experieince.. i've also heard about people shitting blood when taking tremendous amounts of LSD that you would probably never take. read about it on the overdose section of wickepedia just seems like it has potential to mess with the gut. EDIT: accidently wrote "the overdose section of reddit" if anybody cought that before i edited it... the Overdose section of wickepedia mentions people shitting blood on tremendously high doses.
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While gastroparesis can cause constipaiton it is not just extreme constipation. Its when your bowels do not work as quickly as they should. It slows gastric emptying therefore in a healthy average adult if it takes 3-4 hours for someone with gastroparesis it could take 6-7 hours. These arent exact numbers just a explanation. I appreciate the response though.
 
I think iom basically said what I would have said. All psychedelics come with a risk of GI disturbance to some degree. That said, I think there are a few ways to mitigate it. But first, do you have prior psychedelic experience? Do you have any particular outcomes from taking psychedelics that you are hoping for? That might help us rule out some otherwise good candidates.

If nausea is a concern, then predosing with ondansetron can be enormously helpful. You be able to get a prescription for it.

I think it's interesting that most of the posters above find LSD to be less troublesome on the gut. That has not been my personal experience. I find LSD and other lysergamides tend to cause intestinal cramping and gas pain, especially during the comedown. Mushrooms make many people very uncomfortable, but have never caused me any gastric discomfort.

I suspect that reducing the time that a psychedelic is in your gut can often reduce GI distress. Eating dried mushrooms reportedly causes more GI side effects than drinking the tea, presumably because it is rapidly absorbed, leaving very little remaining during intestinal transit. The same is often said about morning glory seeds - famously rough on the guts - when ground, decanted in cold distilled water overnight, and then strained through a coffee filter. So based on this, I think fasting for two hours in an individual with normal intestinal transit time would be good practice to reduce GI symptoms. For you, that could be significantly longer. I would also avoid encapsulating drugs. Instead, consider rolling them up in some weighing paper for ease of swallowing or making them into a tea if you can disguise the flavor.

Routes of administration that bypass the gut entirely can help somewhat, but bring their own set of problems. Rapid comeups and higher peak plasma levels from insufflating or vaporizing your drugs can cause nausea on their own. I get no nausea from oral 2C-B, but insufflated 2C-B can cause me to have some (it's also very painful.) You might do better with vaporizing something in little bursts, working your way up to your ideal dose over time. I could see this working with something like 5-MeO-MiPT even though certain people are genetically predisposed to get side effects from it. Rectal dosing, weirdly, tends to produce experiences that are qualitatively similar to oral experiences, but with fewer GI side effects. That might be worth exploring, too.

There are a few drugs that seem to cause relatively few side effects. 2C-B-FLY is relatively transparent on the body in most reports, but I can't speak to its utility for your unknown use case. Vaporized N,N-DMT is also pretty easy on the stomach, and has the benefit of being quite short acting. I also don't know if it would meet your needs. The two are on very different ends of the spectrum. 2C-EF is another that people have said is quite transparent, but when last I checked there was a lot less information to confirm that compared to 2C-B-FLY or especially vaporized DMT. One final option that I can only speculate on is N,N-DPT. Maybe someone else here has more experience and can speak to the incidence of GI side effects with it. It can be vaporized, lasts a proper amount of time, and is a full-spectrum, well-rounded psychedelic. I didn't like the vibe I got from it, but I could still see it being a good desert island psychedelic. Creepy vibe aside, it was kind of the whole package. But it was easy to vape, to titrate the dose, and it lasts a respectable but not overlong 2hrs. People like it well enough to start a religion around it, so I think it's worth considering. Most of the base tryptamines tend to be more nauseating than their 4-substituted counterparts, but I think that's probably as much a feature of the large amount of materials needed for effective oral dosing. I don't think any of them (not counting alpha methyls) cause much nausea when vaporized.
 
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