Miscellaneous What Psychedelics Do You All Wish Were More Accessible?

[emkee_reinvented]

.. it makes people think that there's some sort of secret society. Tell us about it, won't you?

There is, there were a lot of people that had access to LSD.
Shrooms to, till they were legalised. But you would have to do some serious digging.
And searching i asked and asked that s how i got LSD 2 times in whole my life.
Once gifted. All came via/ via, and it was not waiting on the dealer.
patience till they found you. So you spend 7 year s surching to buy rwo blot s for cheap. To later think i should habe bought more. Next found me 7 tear s later.

Dealer s are dumber and keep it simple. They never sold LSD and DM didn t exist.

 

[emkee_reinvented]

May sound weird but I really wish i could get DXM lol.
In my country its not avaiable over the counter.
And even if I had a bad cough i doubt i could get enough from the doctor for a strong trip.

High dose DXM is one of my favorite experiences.
Its just such a weird and overwhelming trip.

That illegal here too, why no-one hardly used, i used for tickling-cough s.
Worked great, now it s solely Ophadrine i could turn to.
As Codeine ain t OTC any more. Pussy galore.

You can t but hate Politic s no matter how hard i try.
They bring out the worst in me !

Is DXM interesting i wonder ? Curious.

 

[emkee_reinvented]

Are you sure that they are so bad concerning MAO inhibition? 2C-B is a stronger MAO-A/MAO-B inhibitor than 2C-T-2 (not 2C-T-7, granted). Yes, the Alephs are MAOI, but TMA-6 has a lower IC50 than all of them. While I don't suggest combining scarcely studied drugs, with 2C-T by SAR being a worse MAOI than both 2C-T-2/2C-T-7, even with the higher dosage, I don't think I'd worry too much. Do I misinterpret data?

Edit: Of course these studies don't take into account possible metabolites, but they are a pointer.

Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases - PubMed

Psychoactive substances of the 2C-series (2Cs) are phenethylamine-derived designer drugs that can induce psychostimulant and hallucinogenic effects. Chemically, the classic 2Cs contain two methoxy groups in positions 2 and 5 of the phenyl ring, whereas substances of the so-called FLY series...

pubmed.ncbi.nlm.nih.gov

Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure-activity relationships - PubMed

The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude rat brain mitochondrial suspension was used as the source of MAO, several...

pubmed.ncbi.nlm.nih.gov

All my experience s with 2C-T2 were in the aftermath of MDMA.
Used during coming down ala 2C-B, dosages 12/ 14 mg.

The trips were super relaxed, nothing like 2C-T7 reports.
Especially when snorted and/ or in cobination with MDMA.
I don t feel 2C-T7 is 100 %. I would say keep it restricted.
Maybe 2C-T2 to, but i didn t notice adverse effect s at low dosage.

Bit like MTA/ Flatliner s , stupid people willcombine it.
"The combination of serotonin release induction and MAOI activity is likely responsible for the severe serotonergic toxicity and hyperthermia that has occurred with 4-MTA.
https://en.wikipedia.org/wiki/4-Methylthioamphetamine

 

[emkee_reinvented]

DMT. I want a fucking ocean full of crystals. I was enough to last for the rest of my life. Probably my favorite drug, honestly. I've only done N-N-DMT, but I'd totally do 5-MeO-DMT. I've just had some of the best times of my life when I'd use DMT regularly, like 4-5 times a week, or for a whole month one time. It just... it has this ability to reshape my thinking so profoundly, to turn everything upside down.

Sometimes you just have to surrender and die and come back fresh, although when I wasn't breaking through I was usually looking around at Simpsons alien world... it was honestly not always consistent, the visuals, but the wonderful feeling in the body on a dose where I'm still there, that shit surpasses any opioid to me. I've been suicidal for years, but DMT helps me so much with that...

My chemist went and met some chick who said she was infertile. Trap. She got pregnant the month they met so yeah probably never gonna have access to that again, and I don't trust myself making it... He REALLY fucked up though, because he already has a 9-year-old boy and never wanted another kid. He planned to get a vasectomy and never did. Always bragging about how he's never used a condom... I knew it'd bite him in the ass one day, now he's stuck with this controlling chick

Again i thought this you can do yourself, but i haven t maybe i will.
But like Weed it s convinient if you can buy it from someone who is good at it.
You can order 5-Meo-DMT, but not DMT there is no logic in that !

Banned during the war on drug s, they won. So legalise it !
No reason to have people do weird kitchen extraction s.

I d like to try it ! better sooner them later.

 

[TheLightBringer]

Meanwhile 3C-x drugs are the amphetamine equivalents of the 2C-x analogs

Wouldnt it make more sense to say that the 3C-x series is the amphetamine equivalent of the 4-alkoxy variants of mescaline?
Since they are 3,5-dimethoxy subbed with the 4th position changed around for different alkoxy substitutions.

 

[The Holy Quadruplty]

Colour is already fairly accessible. I tried sending you a private message but you have your account security settings ratcheted way up evidently…

There's also 'Comet', aka 4-AcO-MET (get it? aka: 'Azomet', aka: 'Metacetin'), and that's a prodrug to Colour (4-HO-MET, aka: 'Metocin') and the end result is damn near the same thing. Either way, yes, I very much this particular substance, good choice. Another worthwhile and similar compound is: 4-HO-MiPT, aka: 'Miprocin'. Btw, I like your username; made me lol


Actually I believe it does have affinity for the serotonin subtypes 5-HT2A and 5-HT2C. Check out the pharmacodynamics listed on Wikipedia. However, I will agree with you that it is not structurally similar to tryptamines, which feature an indole scaffold + an ethylamine side arm. My first impression is that it looks like an anticholinergic drug similar to the arylcyclohexylamines, but w/two phenyls. Primarily it affects histamine, but secondarily it affects serotonin, whilst weakly affecting dopamine and norepinephrine. And sure enough, it's anticholinergic, too. What a weird compound. Thanks for pointing it out, @The Holy Quadruplty

Darrel Lemaire sure made the Tweetio series sound fun on Hamilton's Pharmacopeia… Also, despite the purported cardio problems that can develop, I would like to dabble some with 4-methylaminorex (aka: 4-MAR, 4-MAX, Euphoria, U4Euh (I'm cringing just writing that), &c.)… and yes, I know there are analogs on the RC market, but it's not the same. Also, if you research it, you'll find that the trans enantiomer, trans-4-methylaminorex, is oddly and specifically not scheduled, only cis-4-methylaminorex. Supposedly the feds thought the trans enantiomer was inactive, but it turns out it's more active than the cis enantiomer. Here's more on the subject archived on the Erowid from Rhodium's old site.

I wish someone would whip up a large RC batch of the trans enantiomer via—if memory serves—potassium cyanate and phenylpropanolamine.HCl (aka: norephedrine hydrochloride). Much safer than making the cis enantiomer from cyanogen bromide which is both deadly poisonous and volatile to boot. No thank you. Blast shield chemistry is pretty hardcore, all things considered. All this was figured out on the Hive circa 2003. Then there's a 2004 federal case in the southern district of Florida, United States of America v William Hahne worth checking out. It established that the 1985 Analog Act didn't apply to trans-4-MAR due to the fact that enantiomers ≠ isomer analogs. Bill still got 48 months for the cis portion the DEA busted him with, and later, after his release, he was arrested again for mailing NBOMe psychedelics to a few of his inmate homies still in the joint. Oops. Bill has good ideas, but poor execution it seems.

Too bad 4-MAR purportedly causes COPD and other cardiotoxic shenanigans. No bueno.

EDIT: Also, I understand 3,4-methylenedioxy-aminorex is active and excellent… there's also a 2C-B-Aminorex that I'm curious about.

I more so meant kind of similar structure to Tryptamines, and yeah it's binding affinity for the Serotonin transporter is like only 15nm, and a metabolite of it lead to the discovery of SSRIs.

I think you should look more closely to Chlorpheniramine's structure, and you'll see what I'm talking about. It's like 2 Tryptamines with the space in-between the phenyls where the Indol would normally be, and the whatever they are called that leads to the Nitrogen part (Not the one that's on the phenyl ring of Chlorpheniramine). Sorry the only things I know about chemicals is all just from reading stuff online about drugs, but trust me I know what I'm saying is not incorrect, and that it's structure is not too far off... Or like if one of the phenyls were removed, and an Indol ring was added to the raining one.

 

[The Holy Quadruplty]

Colour is already fairly accessible. I tried sending you a private message but you have your account security settings ratcheted way up evidently…

There's also 'Comet', aka 4-AcO-MET (get it? aka: 'Azomet', aka: 'Metacetin'), and that's a prodrug to Colour (4-HO-MET, aka: 'Metocin') and the end result is damn near the same thing. Either way, yes, I very much this particular substance, good choice. Another worthwhile and similar compound is: 4-HO-MiPT, aka: 'Miprocin'. Btw, I like your username; made me lol


Actually I believe it does have affinity for the serotonin subtypes 5-HT2A and 5-HT2C. Check out the pharmacodynamics listed on Wikipedia. However, I will agree with you that it is not structurally similar to tryptamines, which feature an indole scaffold + an ethylamine side arm. My first impression is that it looks like an anticholinergic drug similar to the arylcyclohexylamines, but w/two phenyls. Primarily it affects histamine, but secondarily it affects serotonin, whilst weakly affecting dopamine and norepinephrine. And sure enough, it's anticholinergic, too. What a weird compound. Thanks for pointing it out, @The Holy Quadruplty

Darrel Lemaire sure made the Tweetio series sound fun on Hamilton's Pharmacopeia… Also, despite the purported cardio problems that can develop, I would like to dabble some with 4-methylaminorex (aka: 4-MAR, 4-MAX, Euphoria, U4Euh (I'm cringing just writing that), &c.)… and yes, I know there are analogs on the RC market, but it's not the same. Also, if you research it, you'll find that the trans enantiomer, trans-4-methylaminorex, is oddly and specifically not scheduled, only cis-4-methylaminorex. Supposedly the feds thought the trans enantiomer was inactive, but it turns out it's more active than the cis enantiomer. Here's more on the subject archived on the Erowid from Rhodium's old site.

I wish someone would whip up a large RC batch of the trans enantiomer via—if memory serves—potassium cyanate and phenylpropanolamine.HCl (aka: norephedrine hydrochloride). Much safer than making the cis enantiomer from cyanogen bromide which is both deadly poisonous and volatile to boot. No thank you. Blast shield chemistry is pretty hardcore, all things considered. All this was figured out on the Hive circa 2003. Then there's a 2004 federal case in the southern district of Florida, United States of America v William Hahne worth checking out. It established that the 1985 Analog Act didn't apply to trans-4-MAR due to the fact that enantiomers ≠ isomer analogs. Bill still got48 months for the cis portion the DEA busted him with, and later, after his release, he was arrested again for mailing NBOMe psychedelics to a few of his inmate homies still in the joint. Oops. Bill has good ideas, but poor execution it seems.

Too bad 4-MAR purportedly causes COPD and other cardiotoxic shenanigans. No bueno.

EDIT: Also, I understand 3,4-methylenedioxy-aminorex is active and excellent… there's also a 2C-B-Aminorex that I'm curious about.

You're welcome

 

[The Holy Quadruplty]

Also btw, Tryptamine in chocolate if mixed with Nutmegs MAOI effects, what do y'all think. I think some active DMT, or Bufotenine possibly?!

 

[username_required]

Wait so you're saying you like 4-HO-MET but hate 4-AcO-MET? Personally, I can't reliably tell them apart or from placebo. And it's believed that the same way psilacetin is a prodrug to psilocin, so too Comet would be a pro-drug to Colour.


Almost… slight correction:
☞ 3C-E = 3,5-dimethoxy-4-ethoxyamphetamine
☞ Escaline = 3,5-dimethoxy-4-ethoxyphenethylamine

Remember:
☞ 2C-x drugs are phenethylamines, none of which are alpha-methylated
☞ 3C-x drugs are amphetamines, which stands for "alpha methyl phenyl ethyl amines"

Meanwhile 3C-x drugs are the amphetamine equivalents of the 2C-x analogs.

I wasn't very consistent in portraying these, but just know: everywhere two straight lines converge, there is a carbon atom there and its open valence shells are being filled with electrons donated from hydrogen atoms. Depicting this would be tedious, so chemists use this as a shorthand, if you will… Anyways, I hope this helped someone learn, or understand, something new. If not, sorry about the ramble, peoples!

I more so meant kind of similar structure to Tryptamines, and yeah it's binding affinity for the Serotonin transporter is like only 15nm, and a metabolite of it lead to the discovery of SSRIs.

I think you should look more closely to Chlorpheniramine's structure, and you'll see what I'm talking about. It's like 2 Tryptamines with the space in-between the phenyls where the Indol would normally be, and the whatever they are called that leads to the Nitrogen part (Not the one that's on the phenyl ring of Chlorpheniramine). Sorry the only things I know about chemicals is all just from reading stuff online about drugs, but trust me I know what I'm saying is not incorrect, and that it's structure is not too far off... Or like if one of the phenyls were removed, and an Indol ring was added to the raining one.

Please forgive my iphone finger painting, but is this what you’re referring to?

 

[The Holy Quadruplty]

Pretty much, and like if the other phenyl with the nitrogen was removed.

 

[GooberDoober]

the spice melange

Or mxe, 4-ho-met, or 5 meo-mipt

 

[Bitchniggaz]

That illegal here too, why no-one hardly used, i used for tickling-cough s.
Worked great, now it s solely Ophadrine i could turn to.
As Codeine ain t OTC any more. Pussy galore.

You can t but hate Politic s no matter how hard i try.
They bring out the worst in me !

Is DXM interesting i wonder ? Curious.

People either hate it or love it basicly.
Guess it depends on how you react to it, some get nausea and find it dirty.

The effects is like a mix of a dissio like K, with a serotogenic warmth and heavy closed eye visuals at higher doses.
The visuals remind me of the movie Tron, like a grid turning on with strong green and purple lines and dots creating what is known as the dextroverse.
It can give you heavy immersion and put you in very alien places.
Once i saw a huge portal opening in my roof and a chinese style dragon coming out of it.

Also has cool body effects like the feeling of flying on a magic carpet etc.

 

[GooberDoober]

People either hate it or love it basicly.
Guess it depends on how you react to it, some get nausea and find it dirty.

The effects is like a mix of a dissio like K, with a serotogenic warmth and heavy closed eye visuals at higher doses.
The visuals remind me of the movie Tron, like a grid turning on with strong green and purple lines and dots creating what is known as the dextroverse.
It can give you heavy immersion and put you in very alien places.
Once i saw a huge portal opening in my roof and a chinese style dragon coming out of it.

Also has cool body effects like the feeling of flying on a magic carpet etc.

I always felt like it was basically Disso + Mdma headspace with more colorful slightly lysergic acid type visuals and then a heavy opiate on top. The opiate element has always been really apparent to me.

 

[emkee_reinvented]

People either hate it or love it basicly.
Guess it depends on how you react to it, some get nausea and find it dirty.

The effects is like a mix of a dissio like K, with a serotogenic warmth and heavy closed eye visuals at higher doses.
The visuals remind me of the movie Tron, like a grid turning on with strong green and purple lines and dots creating what is known as the dextroverse.
It can give you heavy immersion and put you in very alien places.
Once i saw a huge portal opening in my roof and a chinese style dragon coming out of it.

Also has cool body effects like the feeling of flying on a magic carpet etc.

Sound a lot like MXE i admit, especially when you take it daily.
It became a sort of AD/ stimmy/ disso. Guessing DXM is more akin to non functional.
Version of MXE. To bad i missed it, it was the best for 'tickly' cough s they had.
It sound s not to bad in the lower plateus, i read so many report s and the trip s almost went two way s. But the glowing report s were promising.

Codeine was worthless for this, wonder if Orphenadrine is any good.

 

[Zopiclone bandit]

Wait so you're saying you like 4-HO-MET but hate 4-AcO-MET?

Yes 100%

I will take The Pepsi Test with those two any day.

 

[Ismene2]

I long desperately for 4-aco-dmt - that is my ultimate psychedelic. But it HAS to be the white/tan stuff. The grey stuff - the only shit you can get in the UK - is an absolutely wank synthesis that causes massive nausea when you push the dose.

The white 4-aco - I would spoon that motherfucker down like a baby eating rusks. I could not take enough of it. The more i took the more I laughed. I'd start with 150mg to get warmed up. Lay down for an hour, take another 150mg. Then I'd start fucking dancing for hours. Every 3 hours or so - spoon another 150mg down. Hail Mary

 

[TheLightBringer]

I long desperately for 4-aco-dmt - that is my ultimate psychedelic. But it HAS to be the white/tan stuff. The grey stuff - the only shit you can get in the UK - is an absolutely wank synthesis that causes massive nausea when you push the dose.

The white 4-aco - I would spoon that motherfucker down like a baby eating rusks. I could not take enough of it. The more i took the more I laughed. I'd start with 150mg to get warmed up. Lay down for an hour, take another 150mg. Then I'd start fucking dancing for hours. Every 3 hours or so - spoon another 150mg down. Hail Mary

I assume you had massive tolerance but holy fuck where does the experience even go past 100mg? 450mg+ in a few hours just sounds like a multiple hour DMT trip

 

[Ismene2]

I assume you had massive tolerance but holy fuck where does the experience even go past 100mg? 450mg+ in a few hours just sounds like a multiple hour DMT trip

No nausea tho like nn-DMT - just beautiful euphora. Never got too intense - im dancing and laughing for hours. Incredible drug.

 

[TheLightBringer]

No nausea tho like nn-DMT - just beautiful euphora. Never got too intense - im dancing and laughing for hours. Incredible drug.

Man how were you even able to move, I did almost 70mg 4-HO-MiPT once mixed with weed in a dark room and that shit was close to DMT, I was essentially incapacitated on the peak. I just laid in bed hallucinating dodecahedron fractal like visuals and forgot I was human or even on drugs

 

[M!$TER-ED]

I wish all psychedelics were available to me