I'm not trying to be argumentative, and I generally agree with you. ... So, thank you, is what I'm saying and I hope you're not offended by any of this pushback. Not the intention. One love.
It's all good unodelacosa. I'm all for encouraging discussion.
Mescaline is extremely potent
if you know what you're doing.
Firstly, taking ALDH inhibitors with Mescaline does not change the fact that Mescaline is not potent in the mg for mg sense when compared to virtually any other psychedelic drug.
Agreed. I think assessing the receptor binding profile & overall potency of a prodrug doesn't give a realistic idea of it's actual activity.
Secondly, what you're implying with "if you know what you're doing" is that anyone not potentiating their mescaline in this manner does not know what they are doing. I've read your posts in other threads and I trust that's not how you intended to come across.
Correct. I could have phrased it differently, maybe "Mescaline is extremely potent
if you know how to improve the efficiency of it's metabolism". This is more diplomatic!
A dose of 150-200mg could be plenty if you have access to the right tools.
And that's extremely potent to you? Come on, now… Allylescaline is ~30 mg dose, 2C-B is ~20 mg, and 2C-B-FLY is ~8 - 11mg dose. DOB is like 0.8 mg while LSD is 0.1 mg as the standard dose.
These are potent, to
extremely potent drugs.
I purposefully overestimated the ranges since I assumed that if someone did verify it themselves they (probably) wouldn't tweak every single variable to absolutely maximise the potentiation which could make 20-90mg mescaline seem potent. They'd thus call BS on my claims.
On that theme, it would be interesting to see how potent mescaline is for someone of Asian descent with ALDH2 deficiency. I imagine they wouldn't need to use any ALDHIs. I wonder if any 'ALDH2 deficiency potentiation effect' would be prevented by a diet rich in the ALDH inducer sulforaphane which is highest in cruciferous vegetables (eg bok choy/pak choi, broccoli etc). The other common ALDH inducers are taurine, pantethine and lipoic acid supplements which would theoretically render mescaline mostly inactive. I somehow doubt anyone would want to try this.
Mescaline is not among their ranks in that department, no matter how much you want them to be.
I think the active metabolites are.
Enzyme suppression techniques are a separate thing and don't count here. Regardless, enzyme suppression doesn't increase the drug's potency sufficiently to call it "extremely potent."
The enzyme modification approach I'm referring to (ALDHI) works differently to MAOI, it's quite interesting how it works with mescaline. Hence my reference to 'active metabolites' above. The ALDHI approach seems to accentuate a process which normally happens very slowly ie inefficiently when taking pure mescaline. It's likely that other compounds in the cactus facilitate this process.
This post details a novel endogenous tek for accessing phenethylamine and tryptamine experiences. If DMT isn't available for whatever reason then this tek is the next best thing.
What? What does DMT have to do with this?
The person I was responding to mentioned accessing phenethylamines, but why not mention that
the ALDHI technique - which works for plain phenethylamine - also works for plain tryptamine and gives a practical alternative to oral DMT. I do not recommend applying it to potent drugs like amphetamines, 2C-X, psilocybin as it's only been explored with plain phenethylamine, plain tryptamine and mescaline.
It's a common misconception that allylbenzenes form phenethylamines.
"Common"? Also, while there is virtually no direct route – nothing endogenous and maybe a handful of low-yielding one-pot "teks" – an intermediate ketone is formed first and then reduced to the target molecule in the lab, as you know. That's worth mentioning.
The person I responded to was saying that allylbenzenes form amphetamines - which are based on phenethylamine. I replied that the belief this occurs in humans is a misconception (popularised by Shulgin?) as I'm more convinced by the ß-aminoketone route which has several papers behind it. You'd think that Shulgin must have been aware of them since they were looking to verify his idea that allylbenzenes form amphetamines in-vivo. Instead they found ß-aminoketones (phenylpropylamines) which seem an appropriate explanation for the range of psychoactive effects associated with certain botanical oils.
The researchers discovered these ß-aminoketone metabolites for several allylbenzenes including safrole, elemicin, myrstricin, estragole, eugenol etc. … If you prefer to avoid the psychoactive essential oil terpenes then acquire the pure allylbenzenes instead.
NOTE: Some of these are definitely watched and reportable, particularly safrole (aka: 3,4-methylenedioxyallylbenzene) which is a List I precursor with the DEA (and it's similarly watched in virtually every other country, too) and ordering it will very likely attract unwanted attention. Look into your local laws and do not just go ordering essential oils all willy nilly.
There are many common essential oils with relevant levels of allylbenzenes. My comment implied concentrating the allylbenzenes in an essential oil by removing terpenoids. This is one way to acquire them, although not necessarily in pure form. Maybe it depends how skilled the person is. Many allylbenzenes are also sold for perfurmery purposes.
I'll admit that the allylbenzene protocol is either too obscure or appears confusing to most people but from what I recall at least 2 standardised approaches were established.
Things that fall outside the scope and capabilities of the average user have severely limited utility.
Yes, although the standardised approaches were specifically intended for average users.
