back on topic :
Back in my days I used to do R&D for a known company, one of my projects was to find other ways of getting substances into the body.
And as bondmaker so eloquently stated most psychoactives will not reach the final step through the BBB this way,
being it either the wrong polairity , the wrong salt (or freebase) , the wrong insolublility or other reason.
ofcourse we did a series of psycho-active sustances on skin patches and see if they would have a distinctive (non-placebo) effect :
most phenethylamines :
2cb,mdma ,tma-2 (salts / freebases) : not active /not active
DMT (salt / freebase ) : not active / not active
Ketamine (hcl/freebase) : not active / not active
LSD : not active.
the odd one out : 5-meo-dipt freebase
I was not into opiods back then but i'm sure some of those will work transdermal with dmso.
Back in my days I used to do R&D for a known company, one of my projects was to find other ways of getting substances into the body.
And as bondmaker so eloquently stated most psychoactives will not reach the final step through the BBB this way,
being it either the wrong polairity , the wrong salt (or freebase) , the wrong insolublility or other reason.
ofcourse we did a series of psycho-active sustances on skin patches and see if they would have a distinctive (non-placebo) effect :
most phenethylamines :
2cb,mdma ,tma-2 (salts / freebases) : not active /not active
DMT (salt / freebase ) : not active / not active
Ketamine (hcl/freebase) : not active / not active
LSD : not active.
the odd one out : 5-meo-dipt freebase
I was not into opiods back then but i'm sure some of those will work transdermal with dmso.
