indigoaura
Bluelighter
- Joined
- Jan 4, 2009
- Messages
- 1,707
This is pretty interesting: https://sci-hub.st/10.1007/s00213-014-3528-z
I have only skimmed the article, but it seems to show a pretty consistent response to MDMA across multiple testing sites. Although tolerance does play a part, the researchers described evidence for tolerance as only "modest." Interestingly, geographical location played a significant role in some of the subjective effects. "That is, SF participants reported relatively greater ratings of Closeness to Others and Chicago participants reported greater ratings of Anxious following MDMA administration."
"In any case, however, the present findings provide little support for the idea that the first response to this drug is dramatically greater than subsequent uses."
I have only skimmed the article, but it seems to show a pretty consistent response to MDMA across multiple testing sites. Although tolerance does play a part, the researchers described evidence for tolerance as only "modest." Interestingly, geographical location played a significant role in some of the subjective effects. "That is, SF participants reported relatively greater ratings of Closeness to Others and Chicago participants reported greater ratings of Anxious following MDMA administration."
"In any case, however, the present findings provide little support for the idea that the first response to this drug is dramatically greater than subsequent uses."