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What is wrong with the MDMA available today? - v2

I've tried it several times and with several variations, but it's just not a full substitute for MDMA as much as I wanted it to be.
As Shulgin would probably tell you, the borax combo lacks α2A-adrenergic agonism (& possibly Imidazoline-1 agonism although idk of MDMA activates I1). Back in the 70s(?) Shulgin uncovered an mdma-esque combo:
HT2A + α2A + I1 agonists (stimulant: optional)

Interesting though that 5-APB, or any of the Benzofury Four™ has half the number of oxygen atoms as MDMA/MDA/MDE
Those furans are an interesting cyclised form of 3-methoxy-4-methylamphetamine (MMA) which Shulgin mentioned in pihkal. MMA fully substitutes for MDMA apparently.

I'm glad someone got that joke at least… Everyone seems so serious and interprets others as being serious… #smh
If you saw his apparently serious posts in this thread you may be surprised; the comedy writes itself.
 
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Yeah Borax (the Reddit user) called it "Polly", which is a clever portmanteau of "Poly-drug" + "Molly". However, 5-MAPB is more MDMA-like on its own. Taking 2-FMA + 4-HO-MET just seems to interfere more than anything (in an analogous manner, meth during an MDMA high only detracts from the MDMA buzz, all other things being equal).

I think 2-FMA is a fine stimulant that's proven very effective as a safe study aid, and it's routes of administration are has a built in safety mechanisms And there again, , both of which just happened to be widely circulate in the RC scene at the time… definitely not a coincidence. I've tried it several times and with several variations, but it's just not a full substitute for MDMA as much as I wanted it to be. Maybe for some, it is, I guess…

Interesting though that 5-APB, or any of the Benzofury Four™ has half the number of oxygen atoms as MDMA/MDA/MDE


😂 I'm glad someone got that joke at least… Everyone seems so serious and interprets others as being serious… #smh
I TRY to keep good humor at BL. It's easier with you. Can def be tough at times with certain people who just want to appear* correct at all costs.
As Shulgin would probably tell you, the borax combo lacks α2A-adrenergic agonism (& possibly Imidazoline-1 agonism although idk of MDMA activates I1). Back in the 70s(?) Shulgin uncovered an mdma-esque combo:
HT2A + α2A + I1 agonists (stimulant: optional)


Those furans are an interesting cyclised form of 3-methoxy-4-methylamphetamine (MMA) which Shulgin mentioned in pihkal. MMA fully substitutes for MDMA apparently.


If you saw his apparently serious posts in this thread you may be surprised; he gets special treatment
Lol Allylbenzene/schills so mad. He's best set to ignore.
He's gone into dozens of my old posts to talk trash. Some of them hadn't been active for well over a year.
Regarding that particular thread, I made a mistake and admitted it (something he's incapable of). I had read 3,4-dimethoxyamphetamine instead of 2,4-dimethoxyamphetamine and now I'm uneducated.* He's going around BL linking that particular thread now? I hope people do read it as he's trying to overlay unrelated tryptamines to extrapolate SAR :ROFLMAO:

Its sad honestly.

Cant really prove it but in all likelyhood... allylbenzene is an alt account of Tregar (also goes by 69ron) who deleted his own promotional thread after i exposed what a deceitful manipulative sham he is.

Anyway for whatever reason @Allylbenzene has serious vandetta against me. I imagine it will be a life long one.

Any comment I make.. will be followed by one of his, so ill do my best to not respond to his garbage or it will just ruin any thread. It can be difficult, because I can make a comment anywhere on BL, and soon after, i see a "show ignored content" below my comment. It probably qualifies as harassment tbh.
 
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and now I'm uneducated.
You said it, not me.
It would certainly help if you informed yourself about PEA/indole SAR. You have access to 4DQSARs posts which contain all the details.

I hope people do read it as he's trying to overlay unrelated tryptamines to extrapolate SAR :ROFLMAO:
The CEO of Tactogen does it to, he works professionally developing MDMA-like compounds. Perhaps you're very educated at chemistry but not SAR?

He's best set to ignore.
Hopefully you'll respect your decision setting me on ignore. It saves you from theatrics of playing victim and other dramatic exaggerations.
It can be difficult, because I can make a comment anywhere on BL, and soon after, i see a "show ignored content" below my comment. It probably qualifies as harassment tbh.
So you set me on ignore, then willingly view my posts and claim harassment. Ohkay. easy on the drugs.
 
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This is from the Sassafras oil days and maybe more of an American thing but the chemists figured they could A/B leftover distilled Sassafras and the resulting alkaloids were nicknamed "sass". Most people assume that's just some colloquial slang for MDA. Sassafras has a fair few interesting alkaloids.
I am in eastern Europe and never heard term 'sass'. In fact my guess that it was MDA is based only on reading some threads here on BL. For years, my goal has been to experience MDA, but not so long ago came to a conclusion that I already have.
 
I wonder how active cinnamolaurine is on its own, if at all. So was the proposal that it was being converted into something psychoactive? If so, what? Or is it psychoactive on its own?
Afaik it was assumed the sassafras THIQ alkaloids are the primary active species, but I'm not ruling out active metabolites. There's a similar OTC alkaloid called higenamine which has adrenergic activity. How practical a methylenation is I don't know, but N-methylation seems plausible.
250px-%28S%29-higenamine.svg.png
 
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☞ TL;DR below.

This thread started over 10 years ago. If you’re still reading it and you think the whole world has not had MDMA for over a decade… I think you should consider that perhaps that doesn't line up with reality. It certainly hasn't stopped law enforcement from arresting and charging people for possession/PWID MDMA.

Here ☞ this is from the European Union Drugs Agency (EUDA)'s website, taken from the European Drug Report 2026: Trends and Developments:



MDMA – the current situation in Europe (European Drug Report 2026)​

MDMA tablets are typically available in many designs, often colourful replications of brand logos. While MDMA may sometimes appear in other forms, such as edibles, gelatines and lollipops, tablets and powders remain predominant. The MDMA content of retail-level ecstasy tablets is high by historical standards, having increased from around 84 milligrams per tablet in 2011 to 170 milligrams in 2019 and remained at elevated levels since. Ecstasy tablets containing 300 milligrams or more of MDMA remain available in Europe. The continued availability of high-strength products potentially increases the health risks related to MDMA use, as does polysubstance use, which remains common […]

Drug checking indicates low levels of adulteration but concerns about high MDMA content​

While it is difficult to generalise due to limitations in national and European coverage, the available information from drug checking services suggests that MDMA products are generally less subject to adulteration than other illicit drugs that they screened in 2025. This does occur, however, as illustrated by the detection of other substances in MDMA tablets. The proportion of MDMA samples analysed by European drug checking services that were adulterated increased from 9% in 2024 to 15% in 2025, with cathinones, cocaine and ketamine being the most common other unexpected substances found. In 2024 and 2025, the majority of MDMA samples submitted to drug checking services continued to show high MDMA content (tablets) or high purity (powder), creating health risks for consumers […]

MDMA market data​

  • In 2024, EU Member States reported 24 000 seizures of MDMA (17 000 in 2023), amounting to 4.2 tonnes of MDMA powder (3.6 tonnes in 2023) and 10.7 million MDMA tablets (7.2 million in 2023). Türkiye seized 5.1 million MDMA tablets in 2024 (5.2 million in 2023).
  • In 2024, 4 EU Member States reported dismantling 59 MDMA laboratories (36 in 2023): the Netherlands reported 47, Spain 7, Belgium 4 and Germany 1.
  • Seizures of MDMA precursors totalled 23.9 tonnes in 2024 (63.1 tonnes in 2023), mainly in the form of PMK and its glycidic derivatives. At least 24 sites producing PMK from alternative chemicals were reported in 2024.
  • In 2024, MDMA tablets seized in Europe contained on average between 148 and 232 milligrams of MDMA (138-158 milligrams in 2023), and the average purity of seized MDMA powders ranged from 47% to 100% (24-100% in 2023), with half the countries reporting values in the range 69-87% (67-88% in 2023). The Netherlands, a key source country for the supply of MDMA to Europe, reported an average MDMA content of ecstasy tablets of 137 milligrams and 74% purity for MDMA powders.
  • In 2025, a total of 5 857 samples sold as MDMA were tested for psychoactive adulterants by 14 drug checking services in 8 EU Member States. MDMA was the sole psychoactive substance in 85% of the samples, while the remaining 15% contained at least one other psychoactive substance. In the 11 drug checking services in 7 countries that reported in 2024 and 2025, synthetic cathinones were the most frequently detected of these, representing almost 4% of samples sold as MDMA (less than 2% in 2024). Cocaine was found in 2% of MDMA samples tested in 2025, while ketamine was found in 1%.


TL;DR ☞ In summary, drug-checking data suggest that most products sold as MDMA actually are predominantly MDMA: in 2025, 85% of 5,857 samples contained MDMA as the only detected psychoactive drug. However, adulteration increased from 9% in 2024 to 15% in 2025. Synthetic cathinones were the most common unexpected drugs (~4% of samples), followed by cocaine (2%) and ketamine (1%).
 
☞ TL;DR below.

This thread started over 10 years ago. If you’re still reading it and you think the whole world has not had MDMA for over a decade… I think you should consider that perhaps that doesn't line up with reality. It certainly hasn't stopped law enforcement from arresting and charging people for possession/PWID MDMA.

Here ☞ this is from the European Union Drugs Agency (EUDA)'s website, taken from the European Drug Report 2026: Trends and Developments:



MDMA – the current situation in Europe (European Drug Report 2026)​

MDMA tablets are typically available in many designs, often colourful replications of brand logos. While MDMA may sometimes appear in other forms, such as edibles, gelatines and lollipops, tablets and powders remain predominant. The MDMA content of retail-level ecstasy tablets is high by historical standards, having increased from around 84 milligrams per tablet in 2011 to 170 milligrams in 2019 and remained at elevated levels since. Ecstasy tablets containing 300 milligrams or more of MDMA remain available in Europe. The continued availability of high-strength products potentially increases the health risks related to MDMA use, as does polysubstance use, which remains common […]

Drug checking indicates low levels of adulteration but concerns about high MDMA content​

While it is difficult to generalise due to limitations in national and European coverage, the available information from drug checking services suggests that MDMA products are generally less subject to adulteration than other illicit drugs that they screened in 2025. This does occur, however, as illustrated by the detection of other substances in MDMA tablets. The proportion of MDMA samples analysed by European drug checking services that were adulterated increased from 9% in 2024 to 15% in 2025, with cathinones, cocaine and ketamine being the most common other unexpected substances found. In 2024 and 2025, the majority of MDMA samples submitted to drug checking services continued to show high MDMA content (tablets) or high purity (powder), creating health risks for consumers […]

MDMA market data​

  • In 2024, EU Member States reported 24 000 seizures of MDMA (17 000 in 2023), amounting to 4.2 tonnes of MDMA powder (3.6 tonnes in 2023) and 10.7 million MDMA tablets (7.2 million in 2023). Türkiye seized 5.1 million MDMA tablets in 2024 (5.2 million in 2023).
  • In 2024, 4 EU Member States reported dismantling 59 MDMA laboratories (36 in 2023): the Netherlands reported 47, Spain 7, Belgium 4 and Germany 1.
  • Seizures of MDMA precursors totalled 23.9 tonnes in 2024 (63.1 tonnes in 2023), mainly in the form of PMK and its glycidic derivatives. At least 24 sites producing PMK from alternative chemicals were reported in 2024.
  • In 2024, MDMA tablets seized in Europe contained on average between 148 and 232 milligrams of MDMA (138-158 milligrams in 2023), and the average purity of seized MDMA powders ranged from 47% to 100% (24-100% in 2023), with half the countries reporting values in the range 69-87% (67-88% in 2023). The Netherlands, a key source country for the supply of MDMA to Europe, reported an average MDMA content of ecstasy tablets of 137 milligrams and 74% purity for MDMA powders.
  • In 2025, a total of 5 857 samples sold as MDMA were tested for psychoactive adulterants by 14 drug checking services in 8 EU Member States. MDMA was the sole psychoactive substance in 85% of the samples, while the remaining 15% contained at least one other psychoactive substance. In the 11 drug checking services in 7 countries that reported in 2024 and 2025, synthetic cathinones were the most frequently detected of these, representing almost 4% of samples sold as MDMA (less than 2% in 2024). Cocaine was found in 2% of MDMA samples tested in 2025, while ketamine was found in 1%.


TL;DR ☞ In summary, drug-checking data suggest that most products sold as MDMA actually are predominantly MDMA: in 2025, 85% of 5,857 samples contained MDMA as the only detected psychoactive drug. However, adulteration increased from 9% in 2024 to 15% in 2025. Synthetic cathinones were the most common unexpected drugs (~4% of samples), followed by cocaine (2%) and ketamine (1%).
No way dude, a friend of a friend of a "molly" chemist told me that its all meh!

Kidding for anyone who reads this. @unodelacosa presents facts, not hearsay or pseudo phenylpropene science
 
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“1'-Oxoelemicin-PEA isn't real.”

I’m Not Sure What You Mean. It Might Dimerize Easily, But Stomach Acid Should Cleave The Dimer Apart.

I Would Think It Has Been Made Somewhere Before. Please Explain?
 
I probably had around maybe 10 different good pills from 2007-2012 and haven't had any that were even close to as good ever since. I have a theory that its a different substance completely in the pills now days but i never really cared enough to really look into it.
 
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