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What is wrong with the MDMA available today? - v2

GREETINGS CHEMISTRY FAN CLUB SCHIZOPHRENICS


so is what are you saying that there's different crystal forms of MDMA and they feel different?

And that the ATMOSPheric contrails have busted up the 90s vibe crystal which can never come back because all the scientists are infected with MehDMA?

ALL YOUR CHEMISTRY CAN BE SORT OF RIGHT AND YOU STILL MAY BE WRONG THAT THERES A DIFFERENCE IN ACTUAL EFFECTS.

HEY vash445. YO Didgital MADE U LOOK LIKE A BEE EYE TEE CEE ACHE. NO COMING BACK HOMIE

NOBODY BELIEVE U THEY KNOW U CRACKD, U CANT EVEN SCIENCE WHY DIDNT U DRINK TH MDMA WATER LIKE HE SAID. WHAT RHYME WITH "COW" AND "FORWARD" ? VASH445 BECAUSE HE A COWARD

VASH445 wrote:
"THE DRUGS WERE BETTER WHEN I WAS YOUNG AND I KNOW BECAUSE I TRUST MY SHITTY DRUGGED UP MEMORIES AND MDMA SUCKS NOW BECAUSE IM THE QANON OF ILLICIT DRUG DISCUSSION HOLY FUCK THE XFILES IS BACK AND THERES SIX EPISODES ABOUT ME AND MY SOLID CRYSTALMOPHOGROPENISPUMPMOPHOGRAPHY MY COVER AS A RANTING NUTJOB IS BLOWN. FUCK! FLOW TUBE INFINITE ENERGY MY REDUX BITCH MY FUCKING REDUX ACID CRAPMOGROPHIER CAR IS POWERED BY H20 SIT THE F DOWN"
 
GREETINGS CHEMISTRY FAN CLUB SCHIZOPHRENICS


so is what are you saying that there's different crystal forms of MDMA and they feel different?

And that the ATMOSPheric contrails have busted up the 90s vibe crystal which can never come back because all the scientists are infected with MehDMA?

ALL YOUR CHEMISTRY CAN BE SORT OF RIGHT AND YOU STILL MAY BE WRONG THAT THERES A DIFFERENCE IN ACTUAL EFFECTS.

HEY vash445. YO Didgital MADE U LOOK LIKE A BEE EYE TEE CEE ACHE. NO COMING BACK HOMIE

NOBODY BELIEVE U THEY KNOW U CRACKD, U CANT EVEN SCIENCE WHY DIDNT U DRINK TH MDMA WATER LIKE HE SAID. WHAT RHYME WITH "COW" AND "FORWARD" ? VASH445 BECAUSE HE A COWARD

VASH445 wrote:
"THE DRUGS WERE BETTER WHEN I WAS YOUNG AND I KNOW BECAUSE I TRUST MY SHITTY DRUGGED UP MEMORIES AND MDMA SUCKS NOW BECAUSE IM THE QANON OF ILLICIT DRUG DISCUSSION HOLY FUCK THE XFILES IS BACK AND THERES SIX EPISODES ABOUT ME AND MY SOLID CRYSTALMOPHOGROPENISPUMPMOPHOGRAPHY MY COVER AS A RANTING NUTJOB IS BLOWN. FUCK! FLOW TUBE INFINITE ENERGY MY REDUX BITCH MY FUCKING REDUX ACID CRAPMOGROPHIER CAR IS POWERED BY H20 SIT THE F DOWN"
 
GREETINGS CHEMISTRY FAN CLUB SCHIZOPHRENICS


so is what are you saying that there's different crystal forms of MDMA and they feel different?

And that the ATMOSPheric contrails have busted up the 90s vibe crystal which can never come back because all the scientists are infected with MehDMA?

ALL YOUR CHEMISTRY CAN BE SORT OF RIGHT AND YOU STILL MAY BE WRONG THAT THERES A DIFFERENCE IN ACTUAL EFFECTS.

HEY vash445. YO Didgital MADE U LOOK LIKE A BEE EYE TEE CEE ACHE. NO COMING BACK HOMIE

NOBODY BELIEVE U THEY KNOW U CRACKD, U CANT EVEN SCIENCE WHY DIDNT U DRINK TH MDMA WATER LIKE HE SAID. WHAT RHYME WITH "COW" AND "FORWARD" ? VASH445 BECAUSE HE A COWARD

VASH445 wrote:
"THE DRUGS WERE BETTER WHEN I WAS YOUNG AND I KNOW BECAUSE I TRUST MY SHITTY DRUGGED UP MEMORIES AND MDMA SUCKS NOW BECAUSE IM THE QANON OF ILLICIT DRUG DISCUSSION HOLY FUCK THE XFILES IS BACK AND THERES SIX EPISODES ABOUT ME AND MY SOLID CRYSTALMOPHOGROPENISPUMPMOPHOGRAPHY MY COVER AS A RANTING NUTJOB IS BLOWN. FUCK! FLOW TUBE INFINITE ENERGY MY REDUX BITCH MY FUCKING REDUX ACID CRAPMOGROPHIER CAR IS POWERED BY H20 SIT THE F DOWN"
 
^ Hey I got no stake in Vash but why you coming here just to clown people?? And I will stand by didgital cuz he made some of the same stupid mistakes I have/would make lol

Cow and forward? my Homie your NOW CORNERED (was that spose to be hard)

I happen to agree with you that objectively "Loss of magic" is the main problem here --- but you feel better for downin people? Idk what you know but they "Seem" (I say that cuz I dont and cant verify) to know some chemistry --- again digdital has been a long time community member......WHY YOU DOING THIS
Instead of clowning on people read the patents

The molecular weight of MDMA hydrochloride monohydrate is approximately 247.72 g/mol

while the anhydrous hydrochloride salt has a weight of 229.70 g/mol.

 
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Fwiw I don't have 2A tunnel vision. Selective 2A drugs are great for research/medicine but the richness of drugs like LSD, psilocin, DMT and mescaline is thanks to their polypharmacology.

More specifically, agonism of 5HT2a isn't sufficient for psychedelic effects. Instead, the substance needs to be [an agonist of 5HT2a-mGlu2 heterodimers.](https://pmc.ncbi.nlm.nih.gov/articles/PMC3064746/)

All classical psychedelics agonize this heterocomplex.

 
I am not clowning anyone -- I think that is a really sideways way to come into the forum

That said I have no fckin idea if the dude is correct or if you are lol --- I have my suspicions but not being able to do the math myself I will remain humbly quiet.
 
Instead of clowning on people read the patents

The molecular weight of MDMA hydrochloride monohydrate is approximately 247.72 g/mol

while the anhydrous hydrochloride salt has a weight of 229.70 g/mol.



Now that sounds like you may be onto something honestly but again --- I dont know. I got lost on calculating molar mass and that was back when I was trying
 
Fwiw I don't have 2A tunnel vision. Selective 2A drugs are great for research/medicine but the richness of drugs like LSD, psilocin, DMT and mescaline is thanks to their polypharmacology.

More specifically, agonism of 5HT2a isn't sufficient for psychedelic effects. Instead, the substance needs to be [an agonist of 5HT2a-mGlu2 heterodimers.](https://pmc.ncbi.nlm.nih.gov/articles/PMC3064746/)

All classical psychedelics agonize this heterocomplex.


HERTERODIMERS BITCH. IT'S NOT ABOUT GETTING HIGH IT'S ABOUT THE HETERODIMERS

LOOK AT THE MASSES
 
Me? Again I have said many many times I am not a chemist -- I ran into trouble calculating (hypothetical) molar mass -- NO FOR THE 1,000th TIME I AM NOT A CHEMIST.

do I understand biology? Vague AF my guy -- as well as the next person, not as well as someone who specializes in it.

No I do not hold any degree -- though easily could have at any time til my pa passed and I lost my free tuition. (easily could have had A DEGREE not ANY DEGREE -- just to be clear im not that arrogant)

What I do understand is logic.

(You quoted both of us idk whether im suppose to reply or not, ignore this if not as I have been very on record lol)
 
GREETINGS CHEMISTRY FAN CLUB SCHIZOPHRENICS


so is what are you saying that there's different crystal forms of MDMA and they feel different?

And that the ATMOSPheric contrails have busted up the 90s vibe crystal which can never come back because all the scientists are infected with MehDMA?

ALL YOUR CHEMISTRY CAN BE SORT OF RIGHT AND YOU STILL MAY BE WRONG THAT THERES A DIFFERENCE IN ACTUAL EFFECTS.

HEY vash445. YO Didgital MADE U LOOK LIKE A BEE EYE TEE CEE ACHE. NO COMING BACK HOMIE

NOBODY BELIEVE U THEY KNOW U CRACKD, U CANT EVEN SCIENCE WHY DIDNT U DRINK TH MDMA WATER LIKE HE SAID. WHAT RHYME WITH "COW" AND "FORWARD" ? VASH445 BECAUSE HE A COWARD

VASH445 wrote:
"THE DRUGS WERE BETTER WHEN I WAS YOUNG AND I KNOW BECAUSE I TRUST MY SHITTY DRUGGED UP MEMORIES AND MDMA SUCKS NOW BECAUSE IM THE QANON OF ILLICIT DRUG DISCUSSION HOLY FUCK THE XFILES IS BACK AND THERES SIX EPISODES ABOUT ME AND MY SOLID CRYSTALMOPHOGROPENISPUMPMOPHOGRAPHY MY COVER AS A RANTING NUTJOB IS BLOWN. FUCK! FLOW TUBE INFINITE ENERGY MY REDUX BITCH MY FUCKING REDUX ACID CRAPMOGROPHIER CAR IS POWERED BY H20 SIT THE F DOWN"
Hey, let's keep all this nonsense down dude. Vash made some claims, Didgital and a few others contested them, now we're back to square one where people can make claims and present evidence and the sort, stop trying to clown on people and making yourself look clownish in the process. I don't want to see any more of this circus in this thread, I am going to just start deleting shit like this next time I see it.
 
Me? Again I have said many many times I am not a chemist -- I ran into trouble calculating (hypothetical) molar mass -- NO FOR THE 1,000th TIME I AM NOT A CHEMIST.

do I understand biology? Vague AF my guy -- as well as the next person, not as well as someone who specializes in it.

No I do not hold any degree -- though easily could have at any time til my pa passed and I lost my free tuition. (easily could have had A DEGREE not ANY DEGREE -- just to be clear im not that arrogant)

What I do understand is logic.

(You quoted both of us idk whether im suppose to reply or not, ignore this if not as I have been very on record lol)
jveiojajoivioedsac

Not you.
 
For Me, The Last Year I Got Good Rolls Fairly Easily Was 2003.

Think that was the first year I got rolls, blue dolphins. First and best roll. (again setting and time of life greatly affect that) -- Better than BK-MDMA because I had never felt anything like that before.

Probably the most "First use was the best" drug imo actually, maybe mushrooms
 
Is it possible that what’s wrong with the mdma available today is some kind of polymorph problem
 
Is it possible that what’s wrong with the mdma available today is some kind of polymorph problem
There was speculation about this in another thread. But as I've said several times in this thread: I've been taking MDMA out of a batch I purchased 9-10 years ago for the last little bit. Shortly before that I was also sourcing some pressed pills. Both the crystal I've had and the pressed pills have been as good as the stuff I was taking circa-2001 if not better. The source of both insisted on showing it to me on multiple test kits and I really trusted him (and knew where his source was, which was the same source as most people here I'm assuming).

So no I don't think a polymorph can account for the problems many are describing in this thread. For me, MDMA and MDA have not changed at all.
 
Is it possible that what’s wrong with the mdma available today is some kind of polymorph problem
Polymorphs/hydrates/isomers have been endlessly debated if you scroll back enough. Vash mentioned Ritonavir which was an HIV medication that all converted to a more stable less bioavailable polymorph, but they were able to fix that simply by dissolving and putting in a gelcap.

A polymorph is essentially the different ways the molecules can stack to form a unique crystal lattice. However if MDMA is dissolved in any liquid then it exists evenly distributed throughout the solution ie there is no more polymorphism.
 
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