Does anyone here find it odd or at least weird..
We know of have heard of the N-iso Boogeyman of meth.
That this "nope dope" makes you tired similar to the meh MDMA.
That the old "magic" MDMA was typically described as a fine white powder similar to snow..
When it came to "meth" it to was similar...
You either had peanut butter meth or whatever. But it was more "powder" back then. Then "ice shards" that is known today.
A LONG LONG LONG time ago. I remember trawling Dutch forums in MDMA chemistry. I remember reading something called "GLUE BLOCK MDMA.
I don't remember much. But what I do remember is that even if you do have really pure MDMA. It's hard to make blocks of MDMA that we now see.
It's definitely possible in superlabs using what I assume/presume would be heat/pressure rapid recrystallization
What I remember most about glueblock was that "MDMA glueblock" the chunks looked "flat" and artificially grown similar to Niso or nope dope
Or it might just hell even just go back to
Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters
Determining the structural elements that define substrates and inhibitors at the monoamine transporters is critical to elucidating the mechanisms underlying these disparate functions. In this study, we addressed this question directly by generating a series of N-substituted 3,4-methylenedioxyamphetamine analogs that differ only in the number of methyl substituents on the terminal amine group. Starting with 3,4-methylenedioxy-N-methylamphetamine, 3,4-methylenedioxy-N,N-dimethylamphetamine (MDDMA) and 3,4-methylenedioxy-N,N,N-trimethylamphetamine (MDTMA) were prepared. We evaluated the functional activities of the compounds at all three monoamine transporters in native brain tissue and cells expressing the transporters. In addition, we used ligand docking to generate models of the respective protein-ligand complexes, which allowed us to relate the experimental findings to available structural information. Our results suggest that the 3,4-methylenedioxyamphetamine analogs bind at the monoamine transporter orthosteric binding site by adopting one of two mutually exclusive binding modes. 3,4-methylenedioxyamphetamine and 3,4-methylenedioxy-N-methylamphetamine adopt a high-affinity binding mode consistent with a transportable substrate, whereas MDDMA and MDTMA adopt a low-affinity binding mode consistent with an inhibitor, in which the ligand orientation is inverted. Importantly, MDDMA can alternate between both binding modes, whereas MDTMA exclusively binds to the low-affinity mode. Our experimental results are consistent with the idea that the initial orientation of bound ligands is critical for subsequent interactions that lead to transporter conformational changes and substrate translocation.
Which is also kinda funny because it goes back to the MTBE talk with meth in this forum different subsection
Anyone have these symptoms after swallowing crystal?
My blood pressure is super high, heart rate is super high-those of course should be normal from doing meth.. But what concerns me is, my chest begins to hurt. And it's not a little it's so bad that I feel like I'm having a heart attack. It will feel like this for hours. As I lay there, I can feel my heart rate go back to normal, but my blood pressure I feel is still through the roof and the center of my chest where my heart is hurts bad. Like a sharp deep pain. It will hurt like this for days even a week after ingestion. First time it...
EMCDDA intelligence noted that Russia was a major source of PMK and specifically PMK that contained an unusual impurity, namely 1-(4-tert-butylphenyl)propan-2-one
Classifications
C07C45/42 Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
C07C45/515 Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
C07C45/62 Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
C07C45/74 Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
C07C45/82 Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
C07C45/85 Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
C25B3/23 Oxidation
Just so I'm not going too far out there. This is what I based it on … on the molecular similarities..a Mg bisglycinate chelate is ‘double’ bonded. A Mg Glycinate is a ‘single’ bond.
The Mg Bisglycinate chelate and or any double bonded Mineral chelate has up to 6x better absorption, vs single and or ionic magnesium(oxide).
The key: the coordinate covalent bond aka chelation bond
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