It varies, but I think it takes an extreme amount. Sensitivity and tolerance are probably the biggest factors, as well as any health conditions related to the cns.
I've taken up to 14 pokeball candies at once, where one was very strong on friend's who didn't abuse them, which did hit the spot but I remember before that I would barely feel anything off of 10 or so. I had a stupid amount of it, had a stupid tolerance and stupidly took it every other day, so I would like to point out that that had everything to do with it.
I'm sure myself or others I did this with could go higher, but we luckily never had much in the way of negative side effects from mdma, and it is understood that normally this increases after abuse. Eg. You won't feel the positive effects, but you'll feel the negative ones. However, it is very important that I point out that I upped it that high incrementally, literally by an integer of 1. In other words, I didn't jump from 1 to 14, in which case I probably wouldn't be here right now (maybe). I at least had enough sense to do that, as well as follow the most important and basic precautions (not take it with maoi, staying hydrated but not drinking too much, etc). Actually we, but I think I was the worst offender (6 years ago).
Anyway, my first two paragraphs should've sufficed but I'm kind of being chatty right now, so whatever.
