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What is a Lethal dose of MDMA and MDA?

96z28dude

Greenlighter
Joined
Sep 18, 2011
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So last night I took a 400mg capsule of MDA. The only reason I did so much is because ive had molly before and it was all cut to shit and didnt really have much of an effect on me. So I took the 400mg of MDA last night and I was rolling my nuts off at this festival in town. It felt like I was floating when I was walking 8o But I was wondering if someone could tell me what the lethal dose is for MDA and MDMA because I know 400mg is A LOT :D
 
Wow... 400mg... that's a lot consider your new to rolling (I could be wrong about you being new correct me if i am). Well i think 500-1000mg of Mdma is lethal dose depending on tolerance, your size, and quality/being cut with other shit. Mda on the other hand, I have no clue, so I'll let some one with more knowledge answer. Oh and welcome to bluelight this site has done wonders for me, hopefully it does the same for you.
 
I for sure will tell you now, that when perhaps taking supplements , not rolling often and eating serotonin increasing foods the lethal dose is a lot less than usual..

A 180mg pill got me further than someone who took 2 of them at the same time as me. a lot lot further, I was absolutely flying
i would not like to dose any higher than that following a serotonin enriching diet i think it would be fatal
 
Wow... 400mg... that's a lot consider your new to rolling (I could be wrong about you being new correct me if i am). Well i think 500-1000mg of Mdma is lethal dose depending on tolerance, your size, and quality/being cut with other shit. Mda on the other hand, I have no clue, so I'll let some one with more knowledge answer. Oh and welcome to bluelight this site has done wonders for me, hopefully it does the same for you.

I have rolled before. Maybe around 20 times or so. But only 1 time out of the 20 did I roll pretty good and that was from an E pill my friend gave me (purple punisher skull). Not that it matters, im just saying lol But thanks for the advice
 
So last night I took a 400mg capsule of MDA. The only reason I did so much is because ive had molly before and it was all cut to shit and didnt really have much of an effect on me. So I took the 400mg of MDA last night and I was rolling my nuts off at this festival in town. It felt like I was floating when I was walking 8o But I was wondering if someone could tell me what the lethal dose is for MDA and MDMA because I know 400mg is A LOT :D

400mg of MDA is a very very high dose. You should never exceed 500mg of MDA in a single setting because of the high level of neurotoxicty. 80-120mg of MDA is more than sufficient and has a long duration, unlike MDMA. Redosing is optional, and extends the trip unlike MDMA (as noted by Shulgin).

Wow... 400mg... that's a lot consider your new to rolling (I could be wrong about you being new correct me if i am). Well i think 500-1000mg of Mdma is lethal dose depending on tolerance, your size, and quality/being cut with other shit. Mda on the other hand, I have no clue, so I'll let some one with more knowledge answer. Oh and welcome to bluelight this site has done wonders for me, hopefully it does the same for you.

1000mg of MDMA/ MDA is nowhere near the LD50. Hell I've taken a mix of MDA and MDMA in excess of 600mg in a day and I pulled up fine.

500-1000mg of MDMA definitely wouldn't be lethal to 99% of the population.



http://www.bluelight.ru/vb/threads/79027-MDMA-Essential-Guide-v1.00

QFTFT!!!!
 
They are not quite sure what the LD50 of MDMA is in humans. I think in rats it was ~80mg per Kilogram of body weight. If that translates to humans then the laethal dose should be around 4000mg for for someone weighing about 100lbs.
 
They are not quite sure what the LD50 of MDMA is in humans. I think in rats it was ~80mg per Kilogram of body weight. If that translates to humans then the laethal dose should be around 4000mg for for someone weighing about 100lbs.

That number wouldn't translate directly to humans. There's a thread on reddit where someone figured that if you use allometric scaling to account for species differences, you'd get a number around 12 mg/kg. The dea.org harm reduction site guess at 10-20 mg/kg. Those numbers sound intuitively in the ballpark to me.
 
I think the answer is "More than any remotely sane person should even humour the idea of ingesting, even over the span of months" lol
 
Lethal dose studies are not allowed on any humans for any drug for obvious reasons (once you think about it), but in the NA book, one lady says her boyfriend died in the 1960s around Haight Ashbury after taking 10 doses of MDA at once after being apprehended for dealing there by the police. Presuming that they were 100mg each, that would mean that 1000mg of MDA can be fatal but may or may not necessarily be.
 
I think the answer is "More than any remotely sane person should even humour the idea of ingesting, even over the span of months" lol

word...

in a dose probably WAY shorter than the one where you collapse due to serotonin syndrome or overheating, you fry your serotonergic system forever and oh my god then
 
Allometric scaling is largely b.s. In the case of acute toxicity, doses are likely the same between humans and rodents. See for example, this paper : http://onlinelibrary.wiley.com/doi/10.1111/j.1539-6924.1998.tb01117.x/abstract
I wouldn't go so far as to call it definitive bullshit, but it's indeed being debated if allometric scaling has any use in the case of MDMA. Here is another paper that talks about the shortcomings and proposes another method of inter-species scaling

A quote:
There seems to be
no scientific rationale for using allometric scaling to adjust
doses of MDMA between rats and humans because the
pharmacologically relevant doses are similar in both
species (e.g., 1–2 mg/kg). Nonetheless, the complex
metabolism of MDMA needs to be examined in various
animal species to permit comparison with clinical literature
and to validate appropriate preclinical models.

Short answer is that there is no definitive LD50. I think dying from an MDMA OD takes a huge dose, but that doesn't mean lower doses can't cause significant damage. Highest I ever did was about 700-800mg in one night and I'm sure that that had the potential to seriously hurt me, I looked worse than a train wreck. Never again 8)
 
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It varies, but I think it takes an extreme amount. Sensitivity and tolerance are probably the biggest factors, as well as any health conditions related to the cns.

I've taken up to 14 pokeball candies at once, where one was very strong on friend's who didn't abuse them, which did hit the spot but I remember before that I would barely feel anything off of 10 or so. I had a stupid amount of it, had a stupid tolerance and stupidly took it every other day, so I would like to point out that that had everything to do with it.

I'm sure myself or others I did this with could go higher, but we luckily never had much in the way of negative side effects from mdma, and it is understood that normally this increases after abuse. Eg. You won't feel the positive effects, but you'll feel the negative ones. However, it is very important that I point out that I upped it that high incrementally, literally by an integer of 1. In other words, I didn't jump from 1 to 14, in which case I probably wouldn't be here right now (maybe). I at least had enough sense to do that, as well as follow the most important and basic precautions (not take it with maoi, staying hydrated but not drinking too much, etc). Actually we, but I think I was the worst offender (6 years ago).

Anyway, my first two paragraphs should've sufficed but I'm kind of being chatty right now, so whatever. =D
 
I agree with Mike Baumann. I had made some of the same arguments even earlier: http://www.nature.com/npp/journal/v24/n4/full/1395578a.html

Acute toxicity rarely needs scaling. The same injected mg/kg dose produces the same range of peak levels in every mammal. Our organs and proteins generally fail the same whether we are mice or men. A rat can distinguish MDMA from placebo at the same dose as humans.

A main reason you need scaling is if the duration of drug effects is important to the toxicity. In this case the smaller animals will resist toxicity better since their higher blood circulation, kidney filtration, and bigger livers can get rid of the drug faster. On the other hand, when there is a toxic metabolite, smaller animals often have lower ld50s / thresholds for toxicity since they make more metabolite. For example, rats make a lot more MDA than humans when you dose both species with MDMA.
 
That is pretty accurate, and it is the most important reason rats are used in these kinds of experiments when trying to test substances in vitro.

I've just read the whole thing, and finally there is a sense of little bias or an agenda when it specifically refers to the strengths of the arguments from both sides. However, interestingly enough I was wondering what it had to say about a lethal dose instead of neurotoxicity, of which is entirely unproven, but I didn't see it in this report.

Great post though.
 
So last night I took a 400mg capsule of MDA. The only reason I did so much is because ive had molly before and it was all cut to shit and didnt really have much of an effect on me. So I took the 400mg of MDA last night and I was rolling my nuts off at this festival in town. It felt like I was floating when I was walking 8o But I was wondering if someone could tell me what the lethal dose is for MDA and MDMA because I know 400mg is A LOT :D

I'd be surprised if what you took was actual MDA. There are some Beta-Ketone research chemicals about these days which are MDA analogues, and have been passed off as MDA where I live. I haven't seen real MDA in 7 years.

Basically, there is absolutely no way on this planet that you'd be able to walk on that dose. So I suggest that what you took probably wasn't MDA. If I took that dose I'd be rolling around on the floor, having conversations with people who weren't there, thinking I was somewhere I wasn't, all with my eyes rolling into the back of my head.

If you liked it, then try and find out the proper name. :)
 
i would say 400 mg of mda at once (stronger than mdma) is into potentially deadly territory for some people

this goes back to the question of just HOW much MDMA is in said weight.

for example, 500 mg of mdma might not be = to 500 mg of mdma pure substance

from my understanding, there might be salts and other stuff making up most of the weight.

so my understanding is not all mdma weighs the same
 
I doubt that was mda. Did you test it a Simon's regent? Mda can be flooring you at higher doses, and I would think you'd be tripping really hard, to the point of being useless. I've had a combo of the two, lower dose of mda and I was tripping. It lasts a lot longer and I found it completely took over my roll.
 
The lethal dose of MDMA is about 4.2 grams, Not that I know anyone who have done more than 700mgs at once and he almost had Cardiac arrest Or what its called
 
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