Be the man to do itWhat's kind of amazing about PCP is that it gave us the first decent NMDA antagonist for research.
I read the 1970s French patents in which gacyclidine was discovered. It has two chiral centres thus four enantiomers BUT as we know, if one uses a benzene ring in place of the 2-thiophene ring, substitution allows us access to:
-DRI activity
-NMDA receptor activity
-Sigma receptor activity
-Mu receptor activity
But research stopped shortly after dizocipline was discovered.
It's VERY easy to imagine something like TiHKAL but based on the arylcyclohexylamine scaffold.
My BEST guess; if their was just 1 compound I could have made and test, it would be:
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It was discovered that the ketone moiety present in ketamine homologues can be replaced by a (chiral) methyl side-chain. The 2-chloro-5-methoxy I've previously mentioned and pointed to the patent.
But the French patents suggest that the increased NMDA affinity due to the chiral side-chain is truly massive - an order of magnitude. As far as we know the -Cl AND the -OCH3 both increase MOR activity. So it really could be something potent enough to fit onto blotters.
I would LOVE to research ACAiKAL not to trip on exotic compounds but as Shulgin did, be able to refine the QSAR an gain a deeper understanding of how such molecules alter our perception of reality.
BTW Reaxys did show the 2-furyl homologues of PCP but there were no references. I've found that a few times with Reaxys - a compound in their database without any hint on how they got there.
Be the man to do itI'll be one of the unnamed trip reporters
Let me clarify. It's not a criticism of you or for anyone who's been told this line about "Schedule I drugs are drugs with no accepted medical use". To that, I say, 1. law enforcement should not get to determine this; the matter of medicinal utility should be left in the hands of medical professionals who do not have ties to law enforcement. 2. And this totally ignores recreational drug use, spiritual drug use, unconventional psychotherapeutic use, and other non-medical uses. 3. Drug prohibition denies us the basic right that we all have to explore our minds, explore consciousness and 'inner space', so to speak, and the right to autonomous governance of our own physical bodies. That's what I was trying to say so ineloquently. Sorry about that.Why is the concept of a drug having a use stupid?
Yes, used to live in DC, too, and visited friends in Philly semi-frequently back then into the early 2000s. It was also pretty big in NYC back then, especially in Brooklyn and The Bronx, plus it was big in South Central L.A. then, too, rampant in certain hoods.There are 2 main large cities in America where PCP was very big in the 1990's
Philadelphia and Washington DC.
It's certainly not for everyone, but to blanket statement outlaw it in some nanny-state, self-righteous effort to protect people from the scary evils of "the bad drugs" while pharmaceuticals kill people everyday is hypocritical horseshit of the worst variety. It's dismissive to call it "good sense not to mess with it" and just write it off as having nothing to offer but "a nightmare waiting to happen". Hasn't anyone ever seen the 1930s propaganda scare-tactic masterpiece of unintentional hilarity called "Reefer Madness"? Don't you feel like the narrator from that film when you make assertions of how "bad" a drug is? Has it never occurred to anyone that that level of propaganda is behind most drug scares.I heard first hand accounts of people going crazy on this drug. From the drug users I knew. They even had the good sense not to mess with it.
Should it though? It was a groundbreaking discovery that led us to the indisputably useful anesthesia, Ketamine (it's on the WHO's list of essential medicines for example).It seems like it died in 70's and 80's in alot of other places. Like it should.
This is what you sound like:Too much PCP and they will be Naked, violent and have almost super human strength and big problems
Studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often limited to individuals with reputations for aggression regardless of drug use. Although uncommon, events of PCP-intoxicated individuals acting in an unpredictable fashion, possibly driven by their delusions or hallucinations, have been publicized. Other commonly cited types of incidents include inflicting property damage and self-mutilation of various types, such as pulling one's own teeth. These effects were not noted in its medicinal use in the 1950s and 1960s, however, and reports of physical violence on PCP have often been shown to be unfounded
I think you misunderstood what is meant by robust safety profile. I'm talking about the fact that there is a huge distance between LSD's active dose range and LSD's LD₅₀ (lethal dose). Compared to another potent drug like Bromo-DragonFLY, LSD is safe even in very large doses in terms of not causing a medical overdose. Accidental over ingestion of Bromo-DragonFLY for example has notoriously killed people in a rather awful, convulsive manner.i feel like everything you said is probably true except for "LSD has a fairly robust safety profile", at least in my area...
It's the difference between amateurs laying blotter the wrong way and professionals doing it correctly. It stands to reason. Again: it's a good thing LSD has a robust safety profile or you'd hear about LSD overdoses all the time, and instead you hardly ever hear anything of that sort. Sure, maybe people have a freak out experience here or there, but not a technical overdose.i've gotten dramatically different strength blotter from the same group of people... ime lsd analogues that they are selling from research websites are always really accurately dosed, not really with lsd that people are laying on blotter on the streets.
No test kit is capable of telling you how much drug is present. They also can't speak to purity. They simply help to determine if a drug likely is present in the tested matter.i guess they do have those test kits that will show about how many ugs are going to be on the tab too,
And that's what I'm saying you don't seem to appreciate. You'd have to take over 1,000 hits of LSD before it in and of itself became lethal. MIND YOU – at that dose, LSD becomes a deliriant and it's possible someone might accidnetally hurt themselves, but this is a separate instance from overdose.but i've gotten ten strips that one end of the strip is soaked with liquid and the other one isn't... i also met a kid that was selling some type of research chemicals, he put out ten sugar cubes in front of me, and every time he would dose a cube twice, he'd laugh about it. idk. i'd think maybe people like to give people a strong trip every now and then or dealers might have less product and give out some less strong cigarettes or whatever they are putting it on some times.
Of course people have cut their dicks off in the past, sometimes without drugs. Some people are just fucking crazy. Van Gogh cut his goddamn ear off. Granted, it wasn't his dick, but still. Aaaaaand confirmed. Quick trip over to a search engine brings back dozens of stories of this happening in the past. Sometimes because of drugs; sometimes not. This occurrence is still unbelievably uncommon. In fact, it's so uncommon, that when it does happen, there's a news story about it, it seems. Very uncommon events are often newsworthy events. Think about it.i'm gonna guess unless it was just a made up rumour, some one else must've cut their dick off.
And? That proves nothing. That was your experience, not mine for example. And the knowledge of it probably mildly traumatized you and scared you away from drugs because you were a child. It's no wonder you have an irrational fear of PCP and LSD now. Penis dismemberment whilst on PCP is nothing worth obsessing over. Consider using your adult, logical mind to overcome that fear.it was definitely a rumour when i was a kid...
No, that's not what it was. He's actually explained the whole story in interviews before; just look it up. And it's more likely this story inspired the folklore of which you speak, not the other way around.maybe that dude just heard the rumour and then made it a reality though. i really don't know...
That's irresponsible drug use to take a high, unmeasured dose. No one is advocating that. But my point before was that – relative to other psychedelics – LSD has an excellent safety profile, and even if a large dose is accidentally consumed, it's almost never fatal and the person fully recovers, sometimes even enjoying the trip. It is not safe for those prone to violent or psychotic states and/or those with serious mental illness (like schizophrenia) in their family.i just don't think high dose lsd or pcp with out knowing the dose is really safe... i'm not even saying it should be illegal... just a great deal of precaution to go around it.
No, they're not "in it". Drug syntheses are not food recipes. Cooking involves heating and combining ingredients in a specific way and then serving all of those ingredients together, typically. Organic chemistry uses reagents and catalysts on certain precursors to build or reduce them into new target chemicals. And THEN those chems are purified and isolated to over 99% purity in the context of industry. Ether is a useful non-polar solvent; it's removed from the end product. Hydrochloric acid is common; when combined with sodium it's table salt. When bonded to a drug oil, it makes it a water-soluble crystal salt. And it's the acid in your stomach. Potassium cyanide is used as photographic fixer in darkrooms, among other common uses. There are ~50,000 tons of KCN produced each year, that's how common and useful it is, despite being poisonous if consumed by humans (many things fit this description). It's used in a reaction so its atoms can be bonded into another compound which is cleaned to remove unreacted traces of KCN.Ether, hydrochloric acid, and potassium cyanide are in it.
Myth. Fact-check stuff, please.I have heard that embalming fluid is also used in making it.
They're not ingredients. They are chemical reagents. Big difference. Don't fall for that anti-drug, scare-tactic propaganda.Those ingredients are scary.
Thanks, bud. I'm not in the UK; I'm in the US like you. And decriminalization comes first, then legalization. It's a very challenging goal, and it's made worse when people spread false information and sensationalized stories about certain drugs deemed "bad", oftentimes as the result of shoddy, unethical journalism and rushed legislation by lawmakers with a poor understanding of biochemistry. When people don't fact check but simply repeat shit they've heard, these kinds of regretful acts of ignorance can lead to legislation that ruins people's lives for no good reason.Good luck with drug legalization in America or the UK.
Democats? Liberal felines? Lol.The Democats have declared war on pain patients.
I understand your fear. This is why I oppose drug prohibition. It's a line of thinking that seeks to criminalize and punish people under the guise of protection even at the expense of those who genuinely need proper medication.I know this first hand. The left as well as the weĺl as some on the right now dictate what doctors can prescribe.
Hopefully not; keep your head up. I'm sorry you're going through this. I would consider getting a second opinion on this matter, and then maybe consider moving somewhere with more amenable drug laws and fewer restrictions on doctors.I am fucked when my cirrhosis and pancreas troubles get worse.
Well some states in the U.S. are decriminalizing things and controlling them sometimes even. It's not all doom and gloom, but progress is slow. That's why I wish people wouldn't say terrible things about certain drugs as if it's somehow the drug's fault. It's really sad to see.The UK according to people on here, say they are upping the war on drugs; yes I am aware of Scotland.
Unfortunately pharmaceutical companies and doctors are incentivized by profit, and whenever there's a profit incentive, history has shown over and over, ethics need to be examined, b/c people will prioritize profit over their neighbors' wellbeing. Not sure why you think the GOP is any better on drug policy. Meanwhile, every state is trying to stop pill farms from forming with this brainless legislation, red or blue.The first thing that needs to be done is get rid of politicians telling doctors how much they can prescribe to pain patients. I live in a blue state and it gets worse and worse.
It would not matter if you were in a red state with a Republican governor and Donald Trump as president. Laws are passed by Congress; and both political parties posture as if they're tough on drugs and tough on crime. Trump was talking about firing missiles at suspected drug labs in Mexico, regardless of if he has Mexico's approval or not.What do I do when the pain is too much? Not many options, it could be solved and my doctor would write me a lot more but thanks to our democrat governor and President Biden I suffer.
The border being "open" or not pertains to immigration issues. This is a separate issue from Mexican cartels and other TCOs who smuggle drugs into the United States. You're conflating issues out of a desperation to blame 'liberals' for your problems as if the political party matters.Open up the border and here comes the fentanyl.
They're ridiculously bad at drugs, aren't they? When they provided our weed, it was fucking awful garbage full of seeds and stems and had low THC levels. The cocaine they provide is almost always some overpriced, cut, re-rocked bullshit. Meth was good when they made it from ephedrine for a while, but when the feds cut off their Chinese supply of Ma Huang, they started making racemic P-2-P meth and it took them almost a year to figure out how to iteratively resolve the isomers and convert the l- into the d-isomer. And even then, they don't always convert but so much of the isomers, another quality drop. They decide to punch out some fake oxycontin with fentanyl-laced "dirty 30s" but they fucked that up by not milling the ingredients sufficiently leading to the "chocolate chip effect" in the end product – dangerously inconsistent fentanyl pills were the result like the one that killed one of my best friends a couple years ago.The cartels biggest money maker was weed.
No, their statutes are not as bad as the U.S. on the vast majority of substances. You should fact check these things. US drug sentencing on the federal level is out of control. For example, just 5 g of methamphetamine triggers a mandatory minimum sentence of 5 years for first-time offenders, and 10 years if you have a prior. Five little 1g shards = 5-10 years in the US. None of the western world's statutes can compare. Oh and also, 50 grams – that's less than 2 ounces – fetches a 10 - 20 year mandatory minimum. That's absurd.The UK seems to be going in the same direction only no pot legalization. There seems to tougher drug sentences there too.
I was one of those that got Feds involved, there are specific triggers. Mine was crossing state lines to sell a controlled substance. I did most of my time at a Federal Prison. The Fed Prisons were much better than County and State equivalents.I checked reliable legit sources, You just want to fight with me.
The feds are rarely no involved and I was comparing the UK to the rest of Europe
UK is tougher on drugs than many other European countries on drugs.
Those sentencing guidelines are not always used and the feds are usually not involved.
Ether, hydrochloric acid, and potassium cyanide are in it.
I have heard that embalming fluid is also used in making it.
Those ingredients are scary.
i appreciate you taking your time to clear all this stuff up...I think you misunderstood what is meant by robust safety profile. I'm talking about the fact that there is a huge distance between LSD's active dose range and LSD's LD₅₀ (lethal dose). Compared to another potent drug like Bromo-DragonFLY, LSD is safe even in very large doses in terms of not causing a medical overdose. Accidental over ingestion of Bromo-DragonFLY for example has notoriously killed people in a rather awful, convulsive manner.
It's the difference between amateurs laying blotter the wrong way and professionals doing it correctly. It stands to reason. Again: it's a good thing LSD has a robust safety profile or you'd hear about LSD overdoses all the time, and instead you hardly ever hear anything of that sort. Sure, maybe people have a freak out experience here or there, but not a technical overdose.
No test kit is capable of telling you how much drug is present. They also can't speak to purity. They simply help to determine if a drug likely is present in the tested matter.
And that's what I'm saying you don't seem to appreciate. You'd have to take over 1,000 hits of LSD before it in and of itself became lethal. MIND YOU – at that dose, LSD becomes a deliriant and it's possible someone might accidnetally hurt themselves, but this is a separate instance from overdose.
Of course people have cut their dicks off in the past, sometimes without drugs. Some people are just fucking crazy. Van Gogh cut his goddamn ear off. Granted, it wasn't his dick, but still. Aaaaaand confirmed. Quick trip over to a search engine brings back dozens of stories of this happening in the past. Sometimes because of drugs; sometimes not. This occurrence is still unbelievably uncommon. In fact, it's so uncommon, that when it does happen, there's a news story about it, it seems. Very uncommon events are often newsworthy events. Think about it.
And? That proves nothing. That was your experience, not mine for example. And the knowledge of it probably mildly traumatized you and scared you away from drugs because you were a child. It's no wonder you have an irrational fear of PCP and LSD now. Penis dismemberment whilst on PCP is nothing worth obsessing over. Consider using your adult, logical mind to overcome that fear.
No, that's not what it was. He's actually explained the whole story in interviews before; just look it up. And it's more likely this story inspired the folklore of which you speak, not the other way around.
That's irresponsible drug use to take a high, unmeasured dose. No one is advocating that. But my point before was that – relative to other psychedelics – LSD has an excellent safety profile, and even if a large dose is accidentally consumed, it's almost never fatal and the person fully recovers, sometimes even enjoying the trip. It is not safe for those prone to violent or psychotic states and/or those with serious mental illness (like schizophrenia) in their family.
I really don't. You're stubborn and tedious, and I really have lost all interest in trying to share knowledge with you. I'm writing this purely for the sake of the forum, nothing to do with you personally. It's a shame you seem closed-minded to what I've been saying, and that you think I care about arguing with you, but whatever.I checked reliable legit sources, You just want to fight with me.
The feds are rarely involved in what exactly? Because you're out of your mind if you think the DEA rarely get involved in drug cases.The feds are rarely involved
Why? If you live in the US, then laws in the UK and EU don't affect you, so what point are you making with this?and I was comparing the UK to the rest of Europe
Ok. And? Same question as above.UK is tougher on drugs than many other European countries on drugs.
You don't know what you're talking about. Federal prison is about 55% drug offenders compared to 17% in the states prison systems, roughly. It isn't the size of the case, it's whether the feds have jurisdiction.Those sentencing guidelines are not always used and the feds are usually not involved in small cases in America.
Hey thanks a lot, @foodcrisis. It's good to know someone appreciates it at least (ahem, @Jnowhere).i appreciate you taking your time to clear all this stuff up...
Thanks for sharing the link. I had not seen the site until today. Please don't place your faith in those Qtests as though they're really all that accurate. They're not. First, they have you eyeballing the process of cutting a tab in half. Then later you're expected to visually identify the shade of blue in the solution and correlate it subjectively to a color-coded legend of drug concentration. What a crock of shit. This industry is so shysty.this is a link to one of those test kits that supposedly test how many UGs are on tabs and what not. i just did a reddit question about it cause i saw about it a couple weeks ago and forgot the name... the person that commented said it is new and it might not even be accurate https://www.miraculix-lab.de/en/faq-lsd scroll down on the page to the part about "Color Series LSD Q Test"