Recently a thread on this forum had people talking about ayahuasca adjuncts, and it came up that the concept of applying adjunct drugs to psychedelic experiences is often worthwhile regardless of what the psychedelic(s) in play are. I have often administered (to myself or others):
- Promethazine or ondansetron as antiemetics.
- Coca tea, xanthines, amphetamines (and bupropion), racetams/noopept, and _afinils to add some energy and clarity to the experience.
- Cannabinoids (and dagga) to synergize with the trip and round things out a little.
- Mitragyna alkaloids and/or tianeptine, sometimes in the presence of soma to downmodulate things a little bit. Benzos work too but you often have to scale up the dose of the serotonergic to counter benzos' mild "dulling" effect on a trip.
- Soma and/or cyclobenzaprine on their own is a beautiful mixer with psychedelics, in my opinion.
- Intranasal oxytocin is an exceptionally brief empathogenic sparkle that I like to add in sometimes.
- Nitrous is an exceptionally brief dissociative sheen that can be nice to add in.
- Acorus calamus as a profoundly unique, non-specific amplifier is cool to play around with, though its carcinogenic traits make me shy away from it nowadays.
- Kanna, cathinones like NEP, and low doses of empathogens can imbue a sort of "light" and "love" to the experience that a full dose of an empathogen sort of overlooks and steamrolls out of the way.
- Salvia, as well as sinicuichi, can be a great way to add some spice to a trip.
- Propranolol and clonidine are helpful for rounding out minor overstimulation, on the somatic front, at least.
