Propofol I've only had in combination with other depressants for IV sedation, so I can't judge it on its own. Same with midazolam.
Chloral hydrate I've briefly reviewed. At 200 mg it was a mild intoxication. It's not terribly interesting; it might be if it were safer.
Diethyl ether: I've only ever done this by taking a deep inhalation from the mouth of the bottle, which gives a mild and short-lasting light-headedness and relaxation. It's nice -- I'd probably do it once in a while if I had some laying around. I'd imagine dousing a rag in it and inhaling from that, or swallowing a spoonful, would give more substantive effects, but I never came across it in the right environment to give that a try.
Oxycodone
