Stimulants Vyvanse tolerance so soon ?

[Patient007]

Hi,
First post, let me know if not okay

I have been prescribed Vyvanse (Elvanse here) for my ADHD (never medicated for adhd before)
As well I’m on Pristiq for depression.
35yo, female, normal weight for size, don’t consume alcohol or other drugs …

Day 1 : 30mg - agitated, lots of anxiety
Day 2 - 10 : Life changing ! So much
energy… calmed all my ADHD symptoms… finally hope !!!! But the effect would wear down around 2pm
Day 3 - Day 15 : I took 1 in morning and 1 in evening and did a few all nighter like that… never more than 30mg at the time … and some days of rest in between…

Day 16 : no effect anymore… whatever the dosage … nothing at all.

Day 12 to 20 : I stayed on 30mg and tried to recover through sleep & proper meals …
Day 22-24 : No meds to do a small break
Day 25 (today) : I started this morning with 30mg then seeing it’s not working too a few more every 3 hours… I must be at 200+ now and apart from feeling tense… no effect no boost nothing…

Have I developped tolerance so soon ? What to do ?

How can 200mg of Vyvanse not make any effect on me as even if I did took quite a bit of it recently I never reached that kind of dosage …

Thank you !

 

[Nurse Ratched]

See my post in JPMorgans thread.

 

[Intel.imperitive]

See my post in JPMorgans thread.

Can you please link

 

[Intel.imperitive]

Try supplementing magnesium theronate, helps with tolerance

 

[Intel.imperitive]

Also supplement calcium carbonate

 

[G_Chem]

Try supplementing magnesium theronate, helps with tolerance

I actually completely stopped drinking coffee until I tried magnesium l-threonate, cuz it no longer worked. Couple weeks after starting I tried a sip and noticed for the first time in years the coffee actually woke me up instead of put me to sleep.

-GC

 

[Intel.imperitive]

I actually completely stopped drinking coffee until I tried magnesium l-threonate, cuz it no longer worked. Couple weeks after starting I tried a sip and noticed for the first time in years the coffee actually woke me up instead of put me to sleep.

-GC

I don't know if Magnesium makes it more intense, but it for sure makes it last longer and reduces tolerance. L-Throsine also helps slightly. Calcium Carbonate helps slightly. Read my notes made for my doctor.

 

[Intel.imperitive]

- Organisation of thoughts

- Less fidgeting, twitching and teeth grinding, but not enough to stop it

- Concentration is slightly improved, but not enough to watch a full movie or read a whole chapter of a book

- Tolerance will slowly build up, this was the first time taking the medication, so many not be as effective later

-Agitation from not being dosed high enough, needed injectable lorazepam to calm down

- Effects starting at 3 hours last 3 hours thereafter

- Equivalent to 5mg Dexedrine or 10mg Adderall, which are commonly dosed at 15mg and 30mg respectively

- Stops me from feeling like thoughts are being read

- Improves visual snow syndrome

- Can't be abused as its a prodrug, cannot be snorted and overdose is hard since only so many enzymes in red blood cells to break down the amino acid L-lsyine and convert L-Dex into Dexamphetamine

- helping with my binge eating disorder, and will stop me using clembuterol and T3 to lose weight

- Had conversations with doctors online who've told me Wellbuterin and Vyvanse are two of the best drugs on the market for depression and ADHD and an excellent combination

- I spoken with many patients on the same combination with positive reviews

- Wellbuterin aids with weightloss, which will stop me taking PEDs, gaining weight and improve my self-esteem

- Wellbuterin is safe on sexual organs, which I have suffered with on SSRIs.

- Wellbuterin increases the effectivity of aripiprazole

- No anxiety or "come-up" like with many stimulants due to the gradual release.

- components of ADHD

1) dopamine related "attention-regulation".

2) Norepinephrine "procrastination/motivation" component.

- Vyvanse aids dopamine related attention regulation and bupropion aids Norepinephrine related procrastination.

- Bupropion aids in withdrawal from illicit substances such as alcohol and cigarettes, two things I'm trying to quit. It will also keep me from trying new substances.

- Risk of serotonin syndrome. Schizoprenics have high serotonin and this is what causes positive schizoprenic symptoms. Clonazepam reducing the utilisation 5-HT serotonin by neurons

- A previous doctor perscribed Sertraline (SSRI) which increases serotonin, this caused me to experience voices, hallucinations and other positive symptoms.

- Bupropion does not have any affect on serotonin

- Normally when I stand up quickly, I blackout but increased heart rate and blood pressure have prevented this

- Although Aripiprazole is a dopamine agonist and Vyvanse increases Dopamine in different receptor subtypes between neurons, they do so via different biological pathways.

- Aripiprazole is more of a dopamine optimiser, and manager than a pure agonist

- Stimulants are strongest at the D1 receptor, while anti-psychotics act on D2 antagonism. Although both medications act on all 5 receptors. Bupropions affect on dopamine are weak, and unlikely to interfere with the supply of dopamine by Vyvanse and then the optimisation of it by aripiprazole.

- Complex dopamine theory suggests that concurrent stimulant-antipsychotic use reduces tolerance and side effects

- Bupropion and aripiprazole combination have proven synergistic in the treatment compared to additional supplementation of an SSRI.

- Bupropion has shown to help improve cognition through mechanisms stimulants do not target

- Bupropion is the best anti-depressant to take with ADHD medications compared to SSRIs because it has no bearing on serotonin, which can cause serotonin syndrome.

- Clonazepam Inhibits neurotransmitter GABA, which reduces anxiety from Vyvanse comedown and will also aid sleep which is affected by stimulants

- Magnesium Threonate, Calcium Carbonate and L-Tyrosine can potentiate the effects of Vyvanse

 

[Patient007]

I actually completely stopped drinking coffee until I tried magnesium l-threonate, cuz it no longer worked. Couple weeks after starting I tried a sip and noticed for the first time in years the coffee actually woke me up instead of put me to sleep.

-GC

Thanks, I don’t drink coffee

 

[G_Chem]

Thanks, I don’t drink coffee

It was more in relation to the other posters comment regarding magnesium l-threonate reducing Amphetamine tolerance. For me it’s effected all stimulants, it was just a profound experience to be completely tolerant to a drug for years and years only to have it disappear completely after some supplements.

-GC

 

[Patient007]

See my post in JPMorgans thread.

Thanks however the other thread is from someone else from 2014.

I have nothing to hide. I’m pretty basic lol I work 9-5… don’t eat so we’re don’t drink enough water for sure… but I don’t drink alcohol or take drugs since a few years now…

 

[G_Chem]

I don't know if Magnesium makes it more intense, but it for sure makes it last longer and reduces tolerance. L-Throsine also helps slightly. Calcium Carbonate helps slightly. Read my notes made for my doctor.

No it doesn’t make it more intense, if anything it makes me groggy so I take the magnesium at night but the next day I’m flying stimulant or not.

-GC

 

[Nurse Ratched]

Thanks however the other thread is from someone else from 2014.

I have nothing to hide. I’m pretty basic lol I work 9-5… don’t eat so we’re don’t drink enough water for sure… but I don’t drink alcohol or take drugs since a few years now…

I didn't realize you posted on someone's comment from 8 years ago. I guess they aren't gonna answer you.

You don't eat?

Have no clue why you can't get off on 200 mgs of vyvance when 70 mgs gets most people properly sorted.....and then some.

 

[Patient007]

I did had breakfast, I do eat… but not 3 meals a day since I started taking Vyvanse as I’m not so hungry anymore.. but I’m still having my calories I think …

It did work. For a few days …

 

[Nurse Ratched]

I did had breakfast, I do eat… but not 3 meals a day since I started taking Vyvanse as I’m not so hungry anymore.. but I’m still having my calories I think …

It did work. For a few days …

I'm not trying to be glib here or make light of your issue but that doesn't make sense unless you have something wrong with the absorption of drugs that you aren't aware of. Only taking it for a few days won't cause any kind of tolerance. I guess you should tell your Dr. this ( if you got it prescribed )

If you got it off the street maybe it's fake. If you don't do other stims and have only been taking it a few days you should be getting off quite nicely. On 70 mgs.

 

[Patient007]

I got it from the pharmacy, it’s called Elvanse here in Spain but it’s the same. I got a prescription for 60mg per day as I told him 30gr wasn’t working anymore he told me I need to up the dosage to 60…

I haven’t taken 200mg in one go tho.
I took 60mg at 12
30 at 2
30 at 4
60 at 6
30 again at 8

Something like that … it’s spread through today

 

[Patient007]

Maybe I do have something wrong with the absorbsion ? I have a lot of acid reflux issues so I take either pantaprazol in the morning … or if I forget it I have to take 5/6 times an anti acid every day
(I’m getting some test done about that soon)

 

[Nurse Ratched]

I got it from the pharmacy, it’s called Elvanse here in Spain but it’s the same. I got a prescription for 60mg per day as I told him 30gr wasn’t working anymore he told me I need to up the dosage to 60…

That's what i was looking for. Now it makes a bit more sense. You have been on 30 mgs for awhile and got upped to 60. So maybe you are acquiring a tolerance.

How long were you on 30 mgs before he upped it ?

 

[Patient007]

a bit less than a month but often I took a dose in the morning then several dose during the night to stay awake …

How do I get rid of that tolerance ? 1 month is still not a lot to build up a tolerance

 

[Nurse Ratched]

a bit less than a month but often I took a dose in the morning then several dose during the night to stay awake …

How do I get rid of that tolerance ? 1 month is still not a lot to build up a tolerance

Once you have a tolerance to a drug the only way to decrease that is to either stop taking it for awhile ( which most people refuse to do ) or go back down to 30 mgs a day and stay there for a bit. Then when you take 60 you feel it.

Taking it at all hours of the day and night increased your tolerance as well. In the US we usually dose stims in the morning ( some take an afternoon dose but usually regret it ) and it's usually 70 mgs for vyvance or 30 mgs for adderall. Different stims and different dosages.

Pretty sure you have tolerance now and keeping increasing the meds trying to get " euphoria " will only make it worse. pretty sure you are running out of your script early right?

There is only one way out and that is to take it as prescribed. yeah, I know that sucks but....................