During the prescription of ADHD medications like vyvanse there isn't any drug titration that happens. In other words when the doctor prescribes this specific medication you just take it the next day regardless of the dose. I only suggest this kind of first time use with drugs that don't require titration. You will be fine if you take all 60mg of the Vyvanse. The maximum dosage for Vyvanse is 70mg a day taken orally, normally in the morning as for taking a high dose on top of first time use, you're going to be awake for a bit. When it comes to your dilemma you will more than likely end up taking all of the Vyvanse, whether you choose to re-dose halfway through the night or take it all at once both will make you alert, focused, and productive hopefully for the whole night. Lastly a harm reduction recommendation to finish things off, please do not think this information applies to all prescription drugs. The information i am giving is strictly for this specific inquiry. Good luck, hope this helps, message me if you have any further questions.