yeah I take vyvanse 70mg each day and they never tweaked me out hard,,but they are a long lasting pill-12-13 hours...crazy stuff,,you can only get the effects by taking it orally and it combines indie the small intestine with lysine to activate it into dextroamphetamine basicly...but i was on a lotta adderall before i switched to this Vyvanse 70mg,which is the highest dose..i took 60mg of adderall before statring Vyvanse this year..2 30 mg Adderall XR(extended release) capsules,,,but i use to do a lot of crystal meth and stuff when i was younger so i am used to stimulants , but the 70mg was a good dose even for me,but now after 7 + months sometimes i take open another capsule in the afternoon if i wanna stay up later than normal and swallow about anouther 1/3 or so of the second 70mg..so thats like 70+ 22-23,24is mg extra to get me back where the 70mg was tweaking me almost when i started,so tolerance does build up,just not that much and not that quickly ...