I recently played world of warcraft on a low-ish dose candy trip (and weed). It went really well and was a lot of fun. It allowed me to get more absorbed than normal by the game. Rational decisions were more difficult, but fighting went much more intuitive and creative. It allowed me to get to know a new class of character i just started playing.
Related to games in general (not just video):
I once played poker on the tail end of an acid trip and cleared that table. I ended up with every chip on the table. It rocked.
One time I played Go on shrooms and weed. I'm not a regular player, but this time I just saw the patterns and every weakness or threat. I played my best games ever, easily beating and even toyig with an opponent that is normally my equal.