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  • BDD Moderators: Keif’ Richards | negrogesic

Very high tolerance for Stimulant medications!

S

SuperHighTolerance

Greenlighter
Joined
Feb 9, 2013
Messages
9
Like the title says I am nearing the end of a 2 and 1/2 day binge on alot of Vyvanse. I also am prescribed adderall IR which I like much better but all I had this time was a 30 count bottle of 40mg Vyvanse. Other than Vyvanse and Adderall I don't overuse any other drug. The problem is my tolerance is ridiculously high for stimulants. So I repeatedly overuse just to get the dose that works for me and always run out early. Binges like this are not a regular thing for me but needing alot higher than normal doses are. I guess this just made me realize how high my tolerance really is. Here's how it went this time. I started the vyvanse Thurs afternoon and took 3 at once, 120mg, which is on the low to normal side dose for me. An hour or so later I wasn't feeling how I wanted to so I took two more, this time I broke the capsule and just swallowed the powder, it seems to kick in faster but I know there are differing beliefs about that. From there I didn't document the times I took and how much because I didn't plan on staying up for days but it just happens sometimes. Anyway, now it's Sat evening and I only have 1 left. So from Thurs afternoon to this Sat evening I have taken 1160mg of vyvanse. after the first 1 or 2 doses I do tend to get over talkative but nothing much more than that. If I continue to take them like I did this time, the effects just level out no matter how much I take at once. Sometimes I'll just keep popping more pills to try and feel something different but when it levels out, its over, with Vyvanse or adderall. I've heard about building tolerance over weeks and years but not hours or days like I do. Does anyone else have this high of tolerance?? It can't just be that I'm taking too much, because at lower doses it's worthless, and any dose I take seems to wear off faster for me than others. I Would LOVE to hear from anyone that also has this or similar issue. Thanks!
 
its supposed to help you focus better, not get you high or make you talkative. With that said, 70 mgs of vyvanse twice a day was perfect for focusing for me. I am usually at about 100 mg of adderall a day.
 
perhaps you should consider taking a few antacids with your doses, im not sure if all antacids actually work actually, but omeprazole aka prilosec makes stimulant drugs stronger, orally....... not sure about the science behind this method, but im certain it works......i would guess it raises the bio availability by making your stomach a less harsh environment , but this is just a guess......

try it and let me know how it goes...

:)
 
How long have you been on stimulant medication? I guess that's not too weird if you've been taking them for years, but if its only been like 6 months that's really odd.
 
charles manson said:
perhaps you should consider taking a few antacids with your doses, im not sure if all antacids actually work actually, but omeprazole aka prilosec makes stimulant drugs stronger, orally....... not sure about the science behind this method, but im certain it works......i would guess it raises the bio availability by making your stomach a less harsh environment , but this is just a guess......
:)
Click to expand...

Im not sure this would work with Vyvanse, as stomach acid triggers the pancreas to release digestive juices 1 of which is trypsin- which is required to cleave the lysine from d-amp. Also Vyvanse is 90%+ bioavailible regardless of stomach PH. the conversion happens in the blood which is slightly basic.


A Few Theories:
1. Using them daily in high doses combined with a a low protein diet = Low Dopamine Levels in the Brain
---Solution?: N-Acetyl-Tyrosine or Tyrosine (I prefer the former)

2. Rarely tolerance can increase 1-3 fold during Binges, especially when dehydrated, fasting, an/or when not using supplements.
---Solution?: It's not fun but the only solution to this is taking a long break, and possibly adding in some Lithium(long term use up-regulates d2 receptors), and possibly an NMDA antagonist(not sure if it reverses or just blocks tolerance)

You can also try drinking a protein shake 30minuites after dosing to get the digestive juices flowing. Trypsin's your best friend with Vyvanse and this method has worked for me time and time again
 
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;I've read the Vyvanse patent and trials up and down, it mentions something very important. Taking an excessive dose of Vyvanse actually reduces its effectiveness, a beagle was given a high amount and the blood levels were almost little or no trace of amphetamine. You probably could benefit from sleep, you only get what you give. If you really think it's a tolerance issue, NMDA antagonists like Namenda has shown positive results. Requip is another, prolactin levels in the brain. Vyvanse is the wrong thing to use recreationally. As for taking the powder from the capsule, dissolving in water and splitting the dosage over the day works sometimes ie less is more. But if you sleep, eat, hydrate and exercise you will notice in length and strength of any stimulant.

As for protein shakes,GNC with the accelerated amino acid digestive enzymes makes half of a 70mg feel like taking a full dose. You can try 1tsp baking soda in water 3 times a day too. Taking 1 thirty mins before is recomended. This shit is always discussed but look at your days, hygiene and stress management are more useful than you think. If you seriously think tolerance, Namenda daily dosage does work in my own experience. I took Adderall 40mg for over a year, XR twice a day., and never had problems until stress... Namenda at 15mg worked titrated up to that over a month. My 2 cents...
 
I also seem to have a pretty high tolerance for stimulants and was recently prescribed Adderall IR 20mg.I did use methamphetamine heavily for several years and didnt use it for two years.I used it maybe 7 times prior to being prescribed the Adderall and it had been probably a month since I used meth.

However,I seemed to build a tolerance really quickly with them(granted I was a little over zealous).Started with just 60mg which worked then got up to 160mg in one day. I managed to cut that down using tums to absorb more of the Adderall,which worked for a few days but quickly stopped working. Can using the tricks to potentiate adderall increase tolerance and time it takes for tolerance to go down? I would definatly say I am one of those people whos tolerance has increased 3 fold,which makes me and baby jesus cry,lol.Any other tips for my situation,or just go by whats already been posted?

Pariahprose
 
SgtCuddles said:
2. Rarely tolerance can increase 1-3 fold during Binges, especially when dehydrated, fasting, an/or when not using supplements.
---Solution?: It's not fun but the only solution to this is taking a long break, and possibly adding in some Lithium(long term use up-regulates d2 receptors), and possibly an NMDA antagonist(not sure if it reverses or just blocks tolerance)
Click to expand...

^This.
I'm not sure if I've understood all of your post correctly, but do you do this often/ how much has your tolerance changed in the long-term? Like after these binges where it shoots up, does it go back down almost entirely afterwards or is it going up extremely fast?
 
Pagey said:
^This.
I'm not sure if I've understood all of your post correctly, but do you do this often/ how much has your tolerance changed in the long-term? Like after these binges where it shoots up, does it go back down almost entirely afterwards or is it going up extremely fast?
Click to expand...

No dont do this often...last all nighter I pulled b4 these was in early january and that was almost 48hrs on meth...tolerance went back down but went back up extremely fast with the adderall.at first 40mg was almost to much keeping me up forcing me to either go into work tired as hell or redose(guess which one I picked,lol). I was over zealous and binged for about 7 days,and out of those seven I went two without anything. But my tolerance shot up so quickly in that time that I easily went through 40 20mg IR's.Two wasnt cutting it so I would dose more. Btw,they are prescribed to be taken twice daily,one upon waking and one before 1pm,which I had a hard time following this time around ~.~
 
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^Haha I was talking to the OP sorry.

Although in your situation it knda sounds like the right solution might be to take an extended break from stimulants to give your tolerance time to go back down properly.
 
Thank you to all who replied, I really appreciate the suggestions. After my binge was over and I got in some good sleep I regretted ever posting anything and actually just got on here to delete my profile and posts, lol. I was half expecting some rude replies accusing me of drug abuse, which I admit this situation was, but everyone has been very helpful and supportive which is a pleasant surprise:) If the comment about super high doses of Vyvanse being less effective is correct it makes perfect sense to the situation I was in last weekend. I am used to taking Adderall IR so I thought taking more would result in bigger high. I just got my scrip of adderall today and I can relate Pariahprose, although I've never done meth I did coke almost every weekend before using prescription amps. I get 60 ct 20mg adderall monthly and I always run out early. I have heard of the tyrosine and have been meaning to go to <snip> and pick up a bottle L-Tyrosine in supplement form, thats all I could find for it, but I dont know what NMDA is or Namenda? Can someone explain that to me? Thanks for all your help!

Sorry I'm new to this site and don't know how to respond to someone individually.

@charles manson: I have Zantac (ranitidine) 150mg, Its a little different than Prilosec but does it have the same effect? and tums, lol.

@xxpurplehazexx: I have been taking prescription amphetemines on and off for years. Like 6 years, but I did have considerable breaks in between. I guess my tolerance did lower in the times I wasn't taking any but built up very fast.

Thanks again!!
 
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NMDA refers to a part your brain chemistry and the certain pathways/receptors that particular drugs deal with.That is a simplified answer,someone feel free to post specifics or links ^.^

Pariahprose
 
Okay I officially hate adderall and myself right now. I have had zero control lately. I am sorry to say that I have been up since Wed. With absolutely no sleep. I have to be able to function for the rest of today and have taken all the supplements mentioned. I don't have access to benzo either. No matter what I try I can't get back to any feeling of "normal" and am very uncomfortable. Weirdest and most annoying and noticeable side effect is ,constantly talking to myself and over fidgity. I'm writing in hopes that someone has an idea to help me make it till bedtime. Still have adderall but of course it has very minimal effect at this point. ANY SUGGESTIONS ASAP WOULD BE GREATLY APPRICIATED! PLEASE HELP...
 
Dude.... I understand and love a good stimulant binge as much as the next guy but when you don't actually come down before dosing again (which takes longer than just crashing) it won't be felt as strong, which is perhaps the case here.. If you can't manage to slow it down on your own, procure the blue box of Robitussin. The DXM will bring down the stimulant buzz to a pretty good extent so you can hopefully sleep and the NMDA antagonism if you use it in moderate doses over time will bring down your tolerance as well.

I would appreciate if someone chimed in on the DXM for coming down, as I am unsure if that's a safe option although it is what I use.
 
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Usually mixing DXM and stimulants is frowned upon, not generally seen as safe. I guess it depends on the dosage and timing.
 
^This.
Also, do not take lithium at all unless under supervision of a doctor as constant blood tests are needed during treatment to ensure your safety.
I doubt your doctor would use lithium for this situation.
 
yeah a very long break is the only thing that will help my tolerance. But I know truly that I need to just quit for good. It's a vicious cycle. Whenever I get my scrip each month I use it up in under a week, so there is always a good 2 or three week break in between, depending on if I get some extra from other sources. So by the time I get my scrip the first dose is great, I feel like I'm human again after feeling like shit from recovering each month. That's when I lose all control and try to keep that feeling by taking more and more, then more turns into multiple days and nights before I know it and I'm stuck. Each month I tell myself I'll do better and not take so much, yet each month I seem to get more and more irresponsible with it. Saturday night was the worst. I felt like a damn crack head. By that time I had been up for 90 hours straight! I was having uncontrollable twitches and body movements, it was impossible to stay still. Also, I couldn't stop talking to myself and speaking out loud about anything and everything I thought or did. And sleep was no escape. Even in my sleep I was talking out loud and constantly moving. I could literally hear myself talking in my sleep and it would wake me up throughout the night. Looking back I think I may have actually been in a state of drug induced psychosis. It was terrible, and I was lucky. I never want to get to that point again. So, I want to say thank you to everyone that tried to help me. I realize and admit now that my problem is not with a naturally high tolerance to amphetamines. My tolerance is fucked because I abuse it each month. I desensitize myself to its effects with high doses and continual use until it has virtually no effect. I've been doing this for months and fucking myself over without even knowing it. I've never even heard of becoming desensitized to meds until I started researching high tolerance online. But I'm glad I did because it explains a lot. Hopefully I will do things differently now. Good luck to all and God bless.
 
 
Late reply but, I've used Delsym in the past for tolerance issues. It's a low dose 30mg and it was taken at night. It makes me grit my teeth more than anything and it makes it hard to fall asleep.
 
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