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Very difficult question

THC actually has four isomers, only one of which is produced by the cannabis plant or known to be found in nature and the same one is what is used to make marinol and generic dronabinol pills, l- trans delta 9 THC. If you don't believe me here's shulgin discussing the subject with respect to trying to figure out the nonsensical DEA scheduling of natural THC as a schedule I with no medical use and high potential for abuse and dronabinol as a schedule III with medical use and low potential for abuse.

http://www.druglibrary.org/olsen/dea/shulgin.html

Not all molecules are chiral (pronounce Kiral with a hard "ch" like chaos). In order for a molecule to be chiral it needs to have a chiral carbon. Chiral carbons are identified as a carbon atom which has a different group attached to each of its four bonds, thus it can have at most one hydrogen directly bonded to it. It can have multiple of the same type of atom, say a carbon attached to it so long as the carbons belong to different types of groups. 2C drugs are not chiral because they have no alpha methyl group, but 3C/amphetamine drugs do. In an amphetamine molecule for example, because the alpha carbon now has a methyl group attached to it, one bond is to the alpha methyl, one bond is to the nitrogen, one bond is to the beta carbon and benzene ring, and one bond is to alpha hydrogen. All of these are different groups, and makes the alpha carbon chiral. In 2C drugs, the alpha carbon does not have the alpha methyl group, and the alpha carbon has two of its bonds taken up by hydrogens which are the same type of atom. This means that 2c drugs are not chiral and for example, all 2C-B has basically the same pharmacology.

Edit: I should not that I was not precisely correct about a chiral carbon needing to be present for chirality to exist, and the more knowledgeable moderators were kind enough to not crack the whip on me. That said, this is the most common way for chirality to occur in a molecule.
 
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No reason not to believe you, Turing Machine. 2 Stereocenters, therefore: 4 stereoisomers possible.

I can only agree that any relationship between THC and LSD is complete nonsense, from practically all points of view: Pharmacologically (biological effects), chemically (synthesis and physico-chemical properties), toxicologically (acute overdoses & long-term-effects), different abuse liability etc.

In nature only the active isomer is formed; during the chemical synthesis the other ones are possible, too. To what extend depends on the route.


Peace - Murphy
 
Lol, thanks murphy. I guess my wording came off as a bit more defensive than it should have been considering it was not really a fact that left much room for interpretation or was difficult to prove. I'm at a loss to even explain why I phrased it like that. The shulgin conversation I think does a good job of explaining the subject though.
 
Fornax55 said:
i think what he meant was (in a more metaphorical sense) that every organic substance/entity on earth is essentially composed of the same basic material that the FIRST living cell was composed of.
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I guess you can look that from at that point of view too. But it still is a fail lol =D.
 
Fornax55 said:
i think what he meant was (in a more metaphorical sense) that every organic substance/entity on earth is essentially composed of the same basic material that the FIRST living cell was composed of.
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Lol, by that logic a big black dildo is also a form of acid. Actually that might be more true.
 
pronounce Kiral with a hard "ch" like chaos
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Thank you. I will no longer look like a dick when I say "chiral"...
Actually, how is the "i" pronounced? Does it rhyme with "squirrel" or with "spiral"?
Forgive my ignorance please chemists.
 
Thanks Murph. I'll get cracking on some lyrics, I think "viral" is likely to feature.
 
Lol, I bet rappers from Atlanta probably would rhyme it with squirrel, as in "touch me right thurr".

The alpha carbon in methamphetamine is chiral (mispronounced currel)
So I fed it to my squirrel
And then he went feral (mispronounced furrel)
When I pet a lady's pussy it starts to Purr-el

Edit: sorry if this is causing confusion but it was too much fun to resist
 
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Pulpo said:
All drugs at some point are grown from mother earth. A long time ago, when no life was on earth, a single animate creature was given life out of randomly placed particles, and that one creature evolved into all plants/animals/sea-life we know today.

LSD and Weed and 'Shrooms are the same thing.
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The inherent binding properties of chemistry are universal as are the elements. You may not be able to wrap your head around this one, but all of these molecules are likely to exist elsewhere in some form. Even if they do not, how they came about does not change what they are.

True, you me and this universe are one in a sense, but in another more human sense, these molecules are obviously distinguishable.... you crazy stoner :) .


MurphyClox said:
I can only agree that any relationship between THC and LSD is complete nonsense, from practically all points of view: Pharmacologically (biological effects), chemically (synthesis and physico-chemical properties), toxicologically (acute overdoses & long-term-effects), different abuse liability etc.


EDIT:

Holy shit, I'm in ADD right now??????
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Everything is relative besides the oneness of the concept of the universe.

But yeah, most of these guys don't seem to have made some hyper-rational relation between the molecules of LSD and THC for sure, lol.
 
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There's plenty of literature about isomerization of high-potency cannabis extracts, going back 30 years or so. I've read one reliable report of someone making extremely potent BHO, isomerizing it, and then IVing it.
 
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