Using Omeprazole to help Loperamide cross the BBB?

[tragedy1017]

I read on wikipedia that taking omeprazole(Prilosec OTC) with large amounts of loperamide(Immodium A-D) will cause the loperamide to cross the Blood-Brain Barrier. I read that one would need to buy bulk loperamide from a supplier, as the store bought meds don't have enough in them. Though, if done properly, it would give you opiate-like effects. I was wondering if anyone has tried this? Does it actually work? Is it worth it, even if to just help with W/Ds? What type of dosages are we talking about?

 

[GSpot]

96 generics cost 20bux where im at. IMO should just get high.

 

[The Chemist]

Loperamide alone will give you the desired effects, the problem it presents is buying so much at a time. it would cost me too much to get high off of them IMO. if you're really going to try it, just start slow, go with 100mg of Loperamide at first then seek potentiation when you feel you can handle it.

 

[Ghost-Man]

Wait... I read the same thing on wikipedia about taking substances that are P-glycoprotein inhibitors would allow the loperamide to cross the BBB... But wouldn't take a ridiculous dose of 100mgs of loperamide give you horrific constipation? or would it just be like normal opiate constipation you get from other opiates?

 

[Morphling]

Huge doses of loperamide make me absolutely miserable. Yes, it stops you up, horribly. Makes you feel dehydrated, like having a hangover for two days, and if you try to eat anything you have to chuck it up cause your stomach is so fucked. I hate lope. I find if you take a lower dose, however, it does help with w/d/.

I haven't tried it with omeprazole, to be honest. I don't think it's a good idea. Ok, it opens up your BBB, but by how much?

For w/d, I use a combo of DXM and kava kava, and a bit of l-theanine.

I hate lope lol

 

[RobotRipping]

i use omeprazole and loperamide every day, as i'm trying to escape opiate PAWS with my sanity intact.

I do find that it does make a difference, i can definitely get high from 24-36mg of immodium, the high isn't great though. I haven't attempted doses higher than that because i don't really want to experiment on myself with such things but suffice to say, it works IME.

BTW you can get lope online and omeprazole online for super cheap, insanely cheap. have a look around. I just order it instead of getting it prescribed because it is that much cheaper. You can also try black pepper (i once bought it thinking of trying it out), though you'll probably not shit for a week afterwards.

loperamide is less constipating than morphine and friends IME and IMO. I take 8-10mg a day with omeprazole and though i can tell it's affecting my shits, i still shit 2-3x/day. If i were to switch over to morphine/poppy tea/hydromorphone, there'd be no shit coming out whatsoever lol.

 

[bronson]

Closed. This is a bump of an old thread, which had little harm reductive value to start. At that I think it's more or less covered. PM any questions.