using grapefruit juice to potentate

[phsycra]

Hi

How effective is grapefruit juice in potentiating gabapentin and Xanax? Is it worth goin to the shop and spending money on it?

Thanks

 

[Swimmingdancer]

I don't think grapefruit juice potentiates Gabapentin at all. It does potentiate alprazolam (Xanax), by inhibiting the CYP3A4 enzyme, but I read a study that said the average potentiation was only about 1%. However, I do know some people claim they get effective potentiation from grapefruit juice. But I am not one of them. I would say it's not worth it personally.

 

[nAON]

It won't make a massive difference, but it will help it last longer.

 

[ezkapaid]

Seems better on an emergency basis. I drank the good not-from-concentrate kind about a liter a day, 5-6 days a week for ... ever. year or two. quit drinking it and there was no discernible effect to a steady 40mg dose as far as comfort level or sleep patterns, but the antacids that do the same thing definitely work a little, prolonging half-life(?) of the methadone. and then yesterday i had 24oz of the concentrate-based real juice, while i'm day 9 on 10mg/day down from 30/mg, so it might be coincidence that I felt better longer yesterday. I think you develop a tolerance to it like anything else, and the worthwhile benefit is only found when you use it at random.