Useless Thing for Suboxone, Subutex is the way should be for maintenance opioid depen

[Davevanza]

My friend, a Pharmacists, told me these things..... ( Hopefully useful)



Suboxone Sublingual Film, Use: Opioid receptor partial agonist, antagonist. Opiate dependence (with medical, social, psychological treatment), Ingredients: buprenorphine hydrochloride; naloxone hydrochloride, it comes in Pack 2 mg/0.5 mg [28] and Pack 8 mg/2 mg [28]

Subutex, Ingredients: buprenorphine, Use: Opioid receptor partial agonist, antagonist. Opiate dependence incl maintenance, detox (with medical, social, psychological treatment), it comes in 3 forms of strengths , Pack 0.4 mg [7] ,Pack 2 mg [7] , and last one is Pack 8 mg [7]


As for Suboxone, the ingredients include opioid antagonist.
I just don't understand, why the Company manufacture such as thing, that the effect of the opioid ingredients would cancel out each other.


Anyone got any clue?

 

[spacejunk]

have you had a look at the 'other drugs' forum? there is a heap of discussion on this topic there.

 

[Crankinit]

They don't necessarily cancel eachother out, the naloxone isn't active orally, so if you take the strips as they're intended to be taken (under the tongue) then the buprenorphine is active by itself and works as intended while the naloxone is destroyed by your first pass metabolism.

The intention is that the naloxone becomes active when the formula is injected, preventing IV abuse of the suboxone. This only half works, since in low doses the bupe has a high enough affinity for the opioid receptors that it overpowers the naloxone and you get an opioid effect anyway. However the naloxone does become active at higher doses (over the 8/2mg range), at which point it'll knock the bupe off your opioid receptors and either prevent you from getting high or throw you into excruciatingly painful precipitated withdrawal, depending on whether you're physically dependent or not.

 

[drug_mentor]

^ This.

As the question has been answered and there is plenty about this already on Bluelight if you look I am going to go ahead and close this thread.