I've used heroin, hydromorphone, oxycodone, a few others but the strongest opioid I've touched in around a decade is just 7-OH-Mitragynine, and even that can still induce the homicidal/suicidal behavior that led me to stop using them back when I was terminally ill and constantly in and out of surgery.
Occasionally as a teenager we'd get weird dope, sometimes it was bright colors, and if you eat heroin it doesn't do much since your stomach lyses the acetyl groups off the morphine leaving you with vinegar and morphine HCl, but if you sniff it or drop it under your tongue it works. Sometimes I'd be the one to test the weird shit and even eating it, it often still worked. This was between 2013-2016, and it was probably something like 2MAP or U47700 I'm assuming? We were dumbass teenagers though who didn't care to reagent test a thing.
That same mindset of "I would do ANYTHING not to be dopesick" rn is what leads most addicts into buying whatever "down" they can access. You may have luck sending streetwise people out to go buy dope from randos every 4-6 weeks, then running it through a professional testing laboratory like WEDINOS, if you want to start getting real data on this.
Compounds like 3,6-disubstituted morphinans (heroin, dibenzoylmorphine (the first RC), etc), fentanyl and its countless modified analogs, the countless __zenes and __pynes that could be made, as well as the Bentley compounds are all incredibly potent and can be made by intermediately skilled chemists (say, has a degree and experience but isn't a literal genius). You could almost certainly write a series of Pihkal/Tihkal like books just on a single mu opioid scaffold, let alone all of them together.
Given the recent popularity of O-DSMT and tramadol as well, I'm curious if that's due to availability on DNMs and in Mexico, or if that's due to people genuinely having a taste for opioids that also have (S)NDRI qualities. If that is the case, I'd start combing through peer reviewed academic papers looking for what the next dangerous mu opioid agonist that also features monoamine reuptake inhibition might be. If there's an analog of tramadol with fent's potency, especially if it could be smoked easily (or IV'd without issues), that may be something to look out for too.
Any of those aforementioned skilled chemists with 5 kilos of almond oil (or concentrated vinegar) and a year or two of growing poppies in a 4x8 tent could crank out dibenzoylmorphine, Bentley compounds (___orphine), heroin, etc in their garage. This problem of hyper potent opioids will tragically never go away, the cat's out of the bag imo. The best solution will be focusing on getting people into safer opioids in smarter doses that help them lead happier, more productive lives if that makes sense, and I think everybody here at BL agrees with that. I appreciate the work you're doing for harm reduction a lot.
Sorry for the rant on this, chemistry is a passion of mine and so is helping people, and the opioid crisis is tough. Does a chemist who cares just start growing poppies to convert into pure opium for the lightweights, heroin for the middleweights and Bentley compounds for the heavyweights, to create a safe supply for their community? Then what? How do you keep tolerances down, how do you safely put these in RoAs without hotspots, how do you manufacture enough naloxone to make up for those inevitable mistakes, idk man but it's on my mind a lot.
Thank you again for your work in the harm reduction community, it's genuinely heroic in a plethora of ways.
Edit: Disclaimer for the dumbasses stealing poppies and vinegar after reading this to try making shake and bake dope, you'll kill yourself even attempting this without a serious chem background, and if you had that background you wouldn't need a random BL post to elucidate the requisites for a certain substance like diacetylmorphine, aka heroin.)
