edgarshade
Bluelighter
Time
By Meredith Melnick Wednesday, August 3, 2011
With reader comments
http://healthland.time.com/2011/08/03/study-antipsychotic-drugs-show-no-benefit-for-veterans-ptsd/
By Meredith Melnick Wednesday, August 3, 2011
With reader comments
http://healthland.time.com/2011/08/03/study-antipsychotic-drugs-show-no-benefit-for-veterans-ptsd/
A widely prescribed antipsychotic medication worked no better than a placebo to treat combat veterans' symptoms of post-traumatic stress disorder (PTSD), according to a new study by the Department of Veterans Affairs.
The study, led by Dr. John H. Krystal, director of the clinical neurosciences division of the Veterans Affairs' National Center for PTSD, involved 247 combat veterans who had PTSD that had failed to respond to at least two antidepressants, the usual treatment for post-traumatic stress. The participants were randomly assigned to begin treatment with placebo or the antipsychotic medication Risperdal (risperidone) — one of a class of drug that was prescribed to nearly 87,000 veterans for PTSD in 2009.
After six months, the researchers found that the veterans taking Risperdal showed no improvement of symptoms over the placebo group: about 5% of participants in both groups responded fully to the drug, while 10% to 20% reported some improvement of symptoms.
There were no significant differences between the groups in scores for depression, anxiety or quality of life. But participants in the Risperdal group were significantly more likely to report side effects like weight gain, fatigue and somnolence than those taking placebo.

