Upregulation of Arterial Serotonin 1B and 2B Receptors in Deoxycorticosterone Acetate

[heerutosen]

http://hyper.ahajournals.org/content/39/2/394.full



^ Somebody educated wanna review this please? :D

 

[Dmytry]

seems like they are saying that while they knew that 5-ht2a was responsible for vasoconstriction, they discovered that 5-ht1b and 5-ht2b also play a roll in mediating vasoconstriction, and that these receptors show a greater expression in the presence of aldosterone. aldosterone is responsible for water retention, one of the things mdma is known for. the article doesnt mention mdma once, but the correlation i think you are looking for is that (taking lots of mdma>higher levels of aldosterone>more 5-ht2b receptors>high blood pressure and heart problems)

the article really doesnt say much, just that aldosterone is responsible for a higher expression of 5-ht1b and 5-ht2b, and that 5-ht2b agonists can increase blood pressure by themselves

 

[heerutosen]

Thanx