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Opioids Unpredictable effects

Z

ZeroFries

Greenlighter
Joined
Oct 24, 2009
Messages
22
Anyone notice highly variable effects from opiates? Sometimes the same dosage will make me feel nauseated and dysphoric as hell, other times it will take me to nod land, and still other times it will give me waves of the most wonderful euphoria ever.

Even chilling with a minor buzz, then doing a little bit more, can take me either to dysphoria or euphoria seemingly randomly.

How can a drug have such widely varying effects? -or is it just me. I'm sure those who get addicted experience nothing but euphoria and nods the first few times they use, something which is pretty rare for me but I still use em on occasion chasing that wonderful high.
 
For me opiates are pretty straightforward...based solely on the specific opi and dose. Everyone is different tho. Do you by chance use an opiate of unknown purity like heroin.
 
I do notice it happens more with non standardized opiates such as H, poppy pods, CWE codeine and kratom, but it still happens with oxys (the only opiate med I use)
 
Perhaps you are using too much for your tolerance? I think it's pretty common to feel dysphoric and nauseous if you take too much opiate for your tolerance. Lying down and being still in a cool environment might be helpful to alleviate this IME.

But, for me hydrocodone specifically seems to behave pretty erratically. Sometimes I'll hardly feel an amount that will get me pleasantly buzzed another time (not a tolerance issue, I have always used opioids infrequently). Sometimes hydrocodone is euphoric and relatively side effect free and sometimes it makes me feel sick like you describe; sweaty, dizzy, anxious and/or nauseous.

While other opiates aren't as erratic as hydro, it does seem like the amount of euphoria I get from opes can vary even though the feelings of intoxication increase in a predictable, linear fashion. It's not that they make me feel dysphoric when the euphoria is lacking, they can just have a generic CNS depressant feeling, similar to benzos. Maybe it's worth mentioning that I have always preferred stimulants for euphoria.
 
It happens to me frequently. Sometimes it's bliss and perfect, others it's not so fun.
 
I've never had a bad time on opiates. Sometimes I don't get as high as I would like, which can trigger some negative feelings, but I've never been actually dysphoric on opiates, not even when they make me sick because I still feel good in the mind.
 
ZeroFries said:
Anyone notice highly variable effects from opiates? Sometimes the same dosage will make me feel nauseated and dysphoric as hell, other times it will take me to nod land, and still other times it will give me waves of the most wonderful euphoria ever.

Even chilling with a minor buzz, then doing a little bit more, can take me either to dysphoria or euphoria seemingly randomly.

How can a drug have such widely varying effects? -or is it just me. I'm sure those who get addicted experience nothing but euphoria and nods the first few times they use, something which is pretty rare for me but I still use em on occasion chasing that wonderful high.
Click to expand...

A lot of this has to do with individual pharmacology and how we handle drugs. Opioids can have varying side effects if you're opioid naive, depends on a lot of factors like what you've eaten or drank, dose, and time since last dose.

When I started using I felt nauseous a bit - but after I became tolerant all the side effects went away. I still felt euphoria and definitely got on the nod. It just took more to get there. :|
 
There are a lot of factors, and everybody is different. The non-dosage-standardized opiates, as the OP mentioned usually have those effects, and 99% of the time its just because you took a bit too much for your tolerance.

There are, however, a lot of other factors to consider:

-Route of administration.
-Empty stomach vs. full stomach vs. full stomach after a really fatty meal. (Assuming you're eating your opiates)
-If you're dehydrated, tired, sick, etc.
-If you're dopesick, obviously
-Other drugs/medications in your system, there are a lot of random RX and OTC drugs that affect the action of opiates and interact with the various liver magic that metabolizes opiates. This is quite variable depending on opiate in question, and personal body chemistry.
-Mood
-Placebo effect, if you convince yourself you're going to feel shitty while on opiates, you probably will. *Not saying that you do, just in general.
 
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