Opioids Unanswered Cimetidine Question

[ksralyv2mch]

Ok I have asked the following question in the Lope mega thread and have seen other ask this same question on here and on Opiophile as well.

When using Cimetidine to potentiate benzos or opiates you take them prior to dosage to inhibit P-glycoprotein etc etc etc

well when using Cimetidine for a Lope taper/detox I know you are suppose to take like a gram of cimetidine 1-2 hours before you take your Lope dose. My question is:

If you have been taking a gram a day of cimetidine for like 4-5 days straight, can you skip a day of taking the cimetidine before taking your lope or do you need to take the cimetidine EVERY TIME before your lope dose?

Example:​

1. Day one: 1 gram cimetidine + 40mg Loperamide
2. Day two: 1 gram cimetidine + 38 mg Loperamide
3. Day three: 1 Gram Cimetidine + 36 mg Lope
4. etc etc etc etc

Now after taking a gram of cimetidine, how long is my p-glycoprotein inhibited? (and I read somewhere that once P-glycoprotein is inhibited it takes a couple days for it to return to normal)

 

[dirzted]

If it's not that much trouble, i would say just take it, why do you not want to take it? I mean maybe it does last for days but what's the problem in just taking it anyways? Cimetidine is tolerated at like doses of ten grams or something ridiculous isn't it? haha (don't go taking ten grams but you know what i mean)

 

[Rybee]

Is it causing you stomach problems or something?

 

[ksralyv2mch]

No. no stomach problems, it's more just blowing thru them so fast and I ran out the day I wrote this post and had no money to get more so I Was just curious.