Some of the waxed based ER mechanisms like that in Avinza and Kadian are designed as way polymers that will seep the morphine out over time based of the acidic levels in the GI system. I can basically tell when and where to release. Don't believe me look for the video on Kadian dosing mechanism. However, using the acidic based liquid I would think this would be the best as it would best mimic the conditions in the GI and therefore release as desired probably better than in water. Also it certainly will help with the taste.
