tryptamine cross tolerance

[kingme]

Hello!

I ve got a question that I havent been able to find the definitive answer to and am looking for insight from you wonderful minds

What are the cross tolerances of tryptamines?

I am especially interested in 5-MeO-DALT cross tolerance with mushrooms, but also between mushrooms and other wonderous chems, like phenetilenamines (2c-x's), and MDxx as well (MDAI and Methylone Im looking at you!). aMT will be added to the menu soon and was wondering how that fits in the grand sheme of things

Ive been meaning to build some sort of chart with crosstolerances to help me have great weekends while at the same time preserving the magic of the trips. I usually only use mushrooms once a month, and some form of 2c also about 1/month. But with my growing curiosity and expansion of chemical colors Ive been meaning to understand chemicals and their effects so that i may use more than one at the weekend, or more than one every other week.

Sorry if this has been asked before, but forum searching of tolerances throws up so many different answers that it is very teious to look through thousands.

And I know that chemicals from the same family usually have rather total cross tolerance, so that 5meoDalt with mushrooms the second day would be a waste of mushrooms, but perhaps some of these derivatives are more distant or less powerful not cutting into the joy of using others. Also, while MDxx causes some form of serotonin depletion/release, it might not affect the outcome of 2cx use, for example. Afteruse effects also come into play, while i feel rather lovely for days after shrooming, i feel a bit down after methylone use, so perhaps these could/should fit somehow.

So please help with how you can . Im not asking what to take, just general info on how to best use resources in a limited free time.

 

[solistus]

It varies a TON from person to person, and you won't know anything for sure until you test it out yourself. The mechanisms for cross-tolerance of serotonergics are only partially understood. Some people have very little tolerance issues with any of these substances; others need weeks between each trip on anything or they notice tolerance issues. Likewise - some people seem to notice cross-tolerance between basically all psychedelics, while others don't notice any cross-tolerance between some of them. When you start asking about aftereffects and repeated use over a short time, the number of confounding variables rises exponentially. Long story short - you're not going to find a 'definitive' answer any way except testing it yourself.

In general, the closer related two psychs are, the greater the risk of tolerance issues. Two difference 2Cs, for example, would probably exhibit cross-tolerance almost as strong as tolerance from repeated doses of a single 2C for most people.

Personally, I find that the biggest tolerance and cross-tolerance effect by far is on the peak of a mid-high dose tryptamine trip. The really 'crazy' parts of the mental trip will diminish greatly with tolerance build-up, at least for me. Body highs seem the most resistant to tolerance, with visuals being somewhere in between. So, if you're planning a mix of intense, high dose trips and more recreational low-moderate dose trips, you may wanna put one of the intense ones first, and space them out as much as you can.

MDMA is a weird one. Flips (combining MDMA with a psychedelic) are legendarily awesome. Some people seem to find trips less satisfying and intense in the days after a roll, but others such as myself notice no such effect and sometimes even trip harder/better due to MDMA afterglow effects.

And yeah, if methylone and/or any other specific chems give you hangovers or 'down' periods after use, I'd schedule them for the end of this time period if I were you. Feeling depressed or hung-over is no way to enhance a trip experience, that's for sure.

 

[kingme]

I was not hoping to find the definitive answe, just collect some experience.

For example, I would have thought that if some chem gives me a feeling of being down i would program that one before a trip that leaves me with a positive afterglow, because i am generally resistant to bad trips and would benefit from the leftover high. For instance, I sometimes plan my wild weekend danceathon on friday and have succesful mushroom day trips on sundays that leave me feeling happy and full, even in the aparent exhaustion of the previous nights.

And about the 2cs, I have heard of them being effective and resisting tolerance very well, with doses being able to bring about the same effect even on consecutinve days. So that would make them rather a special breed of psyche.



edit: yeah i just saw the big and dandy tolerance thread. my bad for not finding it before. dont know why the fse is a bit weird for me. oh well, you learn something every day ...