Even on just 100mg Tramadol three times in one day I am feeling mild rebound/withdrawal three days later. Although the analgesia is good and the effects are pleasant it is not worth it to suffer even relatively mild withdrawal symptoms days later. I am on Butrans patch(low dose buprenorphine) and I tolerate it relatively well going on over 8 years. Perhaps I should avoid using Tramadol again.
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OD Moderators: Keif’ Richards | negrogesic
Opioids Tramadol
- Thread starter Mitchb105
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AngelsandFairiesarereal
Bluelighter
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Yessir
Nas47
Road-Weary Traveler
man...tram isn't so bad....i think u enjoy it simply because u toke it on top of ur bupe(there is some synergism between this two-for me bupre is always better with tram)...as to codeine-nah man-for me tram is stronger...i mean-longer lasting,but codeine is true opiate....well tram is strange...one of the last in my opi list....i think that tapentadol would be something way better than tram-for my personal taste.....never tried it although....be well man
ĐmantuNJofra
Bluelighter
that is true, for example first two weeks on taking Venlafaxine brand name Velafax and Alventa from 150mg to 225mg or from 75 to 150mg my eyes were rolling like on tramadol when I take 150mg or less at the time and the withdrawalls are were beaten by buprenorphine but buprenorphine wasnt very helpfull when in effexor withdrawals
What I found telling was that Grünenthal were aware that significantly more potent analogues existed. I suggest that the brief was to design a very cheap low-to-moderate opioid with low abuse potential.
It's unusual for such moderate and short duration of usage would lead to physical dependence, at least based on it's MOR activity. But I would consider such a reaction to be something to consider.
I never tried ODMT but am informed it's more like a classic opioid. I Never figured out why nobody spotted out that (+)ODMT AKA (R,R)ODMT would be twice as potent as the mixture of isomers normally supplied. It would be about x8 more potent than tramadol and can be made from tramadol in two simple steps. I guess that is in the morphine range of potency.
It's unusual for such moderate and short duration of usage would lead to physical dependence, at least based on it's MOR activity. But I would consider such a reaction to be something to consider.
I never tried ODMT but am informed it's more like a classic opioid. I Never figured out why nobody spotted out that (+)ODMT AKA (R,R)ODMT would be twice as potent as the mixture of isomers normally supplied. It would be about x8 more potent than tramadol and can be made from tramadol in two simple steps. I guess that is in the morphine range of potency.
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Now I need to find tramadol(used to be fucking everywhere) and a recipe book for them 2 steps...shit I've heard effexor is "one" of the worst shit to ever WD off of..doc tried to make me take them for anxiety instead of giving me another 12 peaches to last 30 days, fucking dickhead would rather have me hooked on effexor I said hell no, back to the street. Walked out, 10mins later i bought 25 bars from a tweaker to help me instead. And it fucking helped me.
Whatever happened to "ask you doctor about ____ and get the relief you need to live your best life"? Instead it's how about some SSRI'S or SNRI'S or nothing? fucking stupid!
Whatever happened to "ask you doctor about ____ and get the relief you need to live your best life"? Instead it's how about some SSRI'S or SNRI'S or nothing? fucking stupid!
To be clear, you would need to be able to access tramadol as an API. Fair play, the price is something like $70/Kg but you have to be able to buy.
On top of that, if memory serves it's about eight times the potency of tramadol - which is quite potent. I can imagine it offering a much more solid dependence. Be careful.
<EDIT>US5733936Adetails the tramadol analogues. The table in column 19 lists the ED50 of tramadol to be 13.60mg/kg while (+)ODMT (example 10) has an ED50 of 1,13mg/kg i.e.. some x12 more potent.
the ODMT that was sold as an RC was a mixture of the 2 trans isomers. Now the isomer that doesn't have MOR affinity still demonstrated analgesic activity so around x8 more potent for (+)ODMT seems about right. But beware of all animal models. Rough guides only.<./EDIT>
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DeathIndustrial88
Bluelighter
I actually use to enjoy tramadol all on it's own, long before I ever touched heroin or bupe. But you're right, the combo of bupe + trams and some bud & it's very lovely. lolman...tram isn't so bad....i think u enjoy it simply because u toke it on top of ur bupe(there is some synergism between this two-for me bupre is always better with tram)...as to codeine-nah man-for me tram is stronger...i mean-longer lasting,but codeine is true opiate....well tram is strange...one of the last in my opi list....i think that tapentadol would be something way better than tram-for my personal taste.....never tried it although....be well man
Now whenever I was using heroin & then I would go back to trams, they simply did nothing at all except keep me slightly out of withdrawal.
Even when I didn't have any tolerance, it still took at least 5-7 50mg pills of tramadol for me to actually feel anything worthwhile from it.
So I think dosage, tolerance & over all body chemistry plays a big role in how much some one might enjoy tramadol.
Trams are definitely strange & the effects can be lackluster or unpredictable at times, but it was a decent enough opioid that I was hooked on it for 10+ years.
Tapentadol feels kinda similar to trams but I actually find it less enjoyable than tramadol. It's supposedly more potent but it has stronger norepinephrine effects than tramadol & if you take too much, those effects get too strong & it causes some unpleasant side effects (like brain glitching, heavy heart-beat, etc..). It also lacks that light MDMA-ish serotonin release feeling that tramadol has. But it did seem a little bit better as far as actual pain relief goes.
And thanks man! Hope you're doing alright too! I'm just hanging in there!
Nas47
Road-Weary Traveler
Tramadol withdrawl could be harsh for somebody indeed...typically opioid withdrawl at least for me are weak,but it mess with ur serotonin/norepinephrine is bad...but week or ten days abstain and u are clean.....but this butrans patches-at least agony withdrawling from them....except u slowly tapper till 5micrograms/hour....bupe is sticky with all his forms...currently this summer quit two years bupe habbit-patches on skin plus ethanol solution(bucal) from already used ones.....withdrawl from 3-4 mgs daily last a month...paws another two months....Bupe imo is for people with chronic pain or like substitution for very lethal drugs like fent...if u use it to quit for example kratom or even oxy...well possibility to be on this through the rest of ur life is not small brother....not small at all......it's almost like methadone...very long lasting....very long withdrawl....and if u have easy acces to it-programs or sort...ur intention to quit is severely weakening....sad but true...that's how i look on this topic....right or wrong idk
As I am on the patch responsibly and I sincerely have a chronic pain issue I will just use the patches as I have been for the last 8 1/2 years. I feel better from the small dose of Tramadol I used 19 days ago and I am pretty sure that I will not use Tramadol again. I thought I would be okay with one day low dose Tramadol but I was sick for 3 weeks from the use. Not worth the excercise. If I have bad breakthrough pain I may use a little codeine if necessary.