Opioids Tramadol Toxicity?

[Korn3x]

I appreciate your concern, but I am on top of my game when it comes to drugs, not to brag. My original/virgin oxy tolerance was 7.5mg for a nod, so in perspective you can call 20mg a developed tolerance. But if you think its still small in the larger scheme, I did much research on opana before doing it. When I started on it I would use a milligram scale to titrate to the proper dose, starting small. I found that my perfect, nodding dose is currently 5mg of oxymorphone in one snort. The relative potency of two drugs means nothing in the case of equi-potent doses except maybe specific side effects.



Hopefully adding alcohol would not increase the neurotoxicity of tramadol if there is any, as alcohol is one of the most neurotoxic recreational drugs out there. Also, hopefully it will not 'dirty' the smoothish high I get from tramadol. I think I will try this.

Would it make sense to combine alcohol with grapefruit juice 45min before dosing? This way, I would be inducing CYP2D6 (alcohol), as well as inhibiting CYP3A4 (GFJ). Thus encouraging M1, and discouraging SNRI metabolites simultaneously. That is unless, that grapefruit juice also inhibits CYP2D6 to an extent equal to alcohol's induction. What do you think?

you are one lucky son of a bitch. i use probably 1/10th of most of the people on here, nowhere near to everyday, yet my tolerance is at 120mg?? i dont get it. yet others use every day, several times a day, and only achieve a fraction of my tolerance.

am i broken or something? or are other people just lucky? or do most people find that their tolerance builds as quick as mine? i use like 2x a month, 4x a month max.

 

[arthunter888]

^^I've come to know that the average nodding dose for an opiate virgin is 10-20mg. 30mg, seems to be where weekly/monthly users tend to stay at for a while until the habit progresses. 120mg is an insane tolerance for a non-addict. That is if you are eating oxycodone. If you are snorting, this is inefficient and poorly absorbed, but still is high.

Yes I consider myself lucky. I tend to have relatively low tolerance to any drug. Even weed. I guess my body is very efficient with the way it processes chemicals. I think it also helps that I am very healthy, don't smoke cigarettes, drink rarely, and have lowish testosterone.

 

[Korn3x]

^^I've come to know that the average nodding dose for an opiate virgin is 10-20mg. 30mg, seems to be where weekly/monthly users tend to stay at for a while until the habit progresses. 120mg is an insane tolerance for a non-addict. That is if you are eating oxycodone. If you are snorting, this is inefficient and poorly absorbed, but still is high.

Yes I consider myself lucky. I tend to have relatively low tolerance to any drug. Even weed. I guess my body is very efficient with the way it processes chemicals. I think it also helps that I am very healthy, don't smoke cigarettes, drink rarely, and have lowish testosterone.

i either plug 120mg, or IV it. if i IV it i get an intense nod for like 45 mins and am almost unable to perform any tasks. i've sat at my computer and just typed the most random shit in emails because i've nodded so hard. altho after 45 mins the high isn't that impressive. if i plug my dose, then i get a very nice high for about 4 hours. not as much of a nod, but the high lasts way longer.

snorting is a waste when it comes to opiates cuz it lasts only like 1/2 as long. might as well plug or IV to get the most out of it.

 

[arthunter888]

Yeah I just plugged 15mg, felt itchy but not noddy. Then plugged another 3mg an hour later, and became sober and nauseous. I just can't seem to hit the sweet spot with oxy for a nod anymore.

 

[Korn3x]

Yeah I just plugged 15mg, felt itchy but not noddy. Then plugged another 3mg an hour later, and became sober and nauseous. I just can't seem to hit the sweet spot with oxy for a nod anymore.

try taking benadryl. to be honest i've never reached a nod from oxy without the aid of benadryl. i've only ever been able to nod from heroin. the heroin nod is way better, but nodding from oxy with the help of benadryl (i take 25-75mg (usually 75mg) of benadryl 45 mins before i dose my oxy) is still pretty decent. i also drink 1/2 a gallon of white grape fruit juice from concentrate, and make sure i have a meal high in fat content at least 30 mins before i plug.

also with oxy, it's best to dose all at once. anything you dose after u get ur initial effects is pretty much a waste. the most euphoria you can achieve is if the maximum dose is taken all at once. hope that helps.

also, benadryl doesn't add to the euphoria, but only to help you achieve the nod. i take the 75mg of benadryl because i like the nod, but i still don't nod as intense as i would as if i had had heroin. it's still nice tho, and you should look into it.

 

[arthunter888]

^^ Actually, I've felt noddy many times before with oxycodone, without any potentiators, the stipulation being that the dose must be pretty close to, but not over my limit. As I mentioned, I felt pretty good at 15mg, but felt it could go up just a notch. I added 3mg an hour later, and obviously this had an effect because I became nauseous and sober (too much).

I kind of have to be laying down to get any oxy nod, but it pales in comparison to a warm, forced nod after a nice line of opana.

 

[sir_thizzalot]

also with oxy, it's best to dose all at once. anything you dose after u get ur initial effects is pretty much a waste. the most euphoria you can achieve is if the maximum dose is taken all at once. hope that helps.

Whaaaat no way, for me, 60mg, followed by 5 or 10mg every 45 min to an hour the next 3 hours gives me a longgg ass high that keeps getting better. I really think the come up is the high, so you always have a lot in you(so the new stuff coming in is filling up the "open" pleasure spots) and are always somewhat coming up. For me anyways, that's a cheap ass way to add 3 hours to your high(I always do it when I can).

Sorry for the wrongness in theory(maby) but this works wonders for me. I did tons of coke and OC for 2 weeks(almost for free!) and this was my most important finding! Will try benadyrl+weed+OC for a good nod sometime soon though, thanks for that idea!

 

[arthunter888]

I just had a really bad experience regarding tramadol. Yesterday, I slow-dosed and took 250mg of Tramadol (no tylenol) over the course of 3.5 hours, starting at around 3pm. I also drank grapefruit juice at around 4:30 to help maximize the M1 metabolite.

I felt pretty good around 7 (itchy), but I like to boost it with Lorazepam to make it more noddy. I took .5mg of this around 8, and again around 11. I also smoked a half bowl of weed with each lorazepam.

Note that I have done this exact procedure several times before with tramadol (same dose), then mixing lorazepam with weed with no problem. Well, the high was nice and everything was great until the next day (today) I wake up with a pounding headache (back of head) with a little bit of nausea. I ate some pasta and fruits when I woke up and shortly after I get this extreme pressure/nausea in my stomach and puke. I puke several times over the course of the day (they were the most violent hard-heaving pukes I can ever remember).

I smoked some bud tonight and it's helping with the nausea but I still have some head pain (seems to weaken slightly with each puke). What do you think went wrong this particular time?