Opioids Tramadol - Maximizing M1, Minimizing the rest

[arthunter888]

I have posted this question in past tramadol threads, with no helpful responses.

My goal is basically just to use potentiation in a manner that:

(a) Maximizes the opiate effect from M1 (O-desmethyl-tram)
AND/OR
(b) Minimize all other effects (serotonin, norepinephrine, NMDA, etc)

I would like to achieve preferably both goals, but if I must choose one I would prefer eliminating the other effects (b) -- they just feel icky esp. that twinge in the neck-spine. I've done a little research and the only theory I could come up with is:

Would it make sense to combine alcohol with grapefruit juice 45min before dosing? This way, I would be inducing CYP2D6 (alcohol), as well as inhibiting CYP3A4 (GFJ). Thus encouraging M1, and discouraging SNRI metabolites respectively. That is unless, that grapefruit juice also inhibits CYP2D6 to an extent equal to alcohol's induction.

However, I have my uncertainties about this method. Would GFJ and/or alcohol also interact with other enzymes? How would this effect the high, and what would be the NET outcome of metabolites? Also, I have been slow-dosing the tramadol (as I heard this helps), meaning taking one IR every 40 minutes until I've taken 4 tablets. At what point would I consume the potentiator(s) for best results?

 

[hydrochron]

Definently a hour and a half after the first tramadol you take.

I haven't taken them in a few years, but I used to take 2 pills then wait about a hour and take however many I needed. Definently made it stronger. They worked good somtimes, other times I got tweeked out on them.

Good luck, let me know the results.

 

[HdoubleODeezy]

what effects would different amino acids have on tramadol?

earlier i took "Amino Fuel" which has like 20-25 amino acids and proceeded to take my hydroxyzine, clonidine,klonopin and suboxone as prescribed.. then my back was hurting about two hours after taking the meds listed so i took 200mg tramadol and 30minutes later i was feeling like a full on opiate euphoria! i was so confused about it i started accusing my family of drugging me so i fail a drug test and go to jail (i get real paranoid..im on bail and my mom hates me lol).. anyways i take this mix of meds EVERY day w/o the amino acids.. could all of the amino acids caused this along with suboxone and tramadol? if so then i suggest someone else try it if they can.. but im still puzzled about this, i mean it has been 3 years since i felt the warmness and bliss that i just got earlier.. weird

EDIT: btw i am trying it again right now to see if i get the same results and if i do than i can rule out someone drugging me and rule in that i found a new way to enjoy my suboxone, tramadol and k-pin combo

EDIT 2: second attempt worked just as the first. .. i have no idea which of the millions of amino acids listed on the bottle do what but they do something!