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  • BDD Moderators: Keif’ Richards | negrogesic

Tramadol for stim cmedowns

^^this

If your simply talking about common prescription amphetamines such as adderall or vyvanse, using tramadol would be ok afterwards.

Other stims that also have strong effects on serotonin can be dangerous to combine with. Depending on how much time is in between the two its best to avoid.
 
I took Tramadol for meth comedowns twice.

Both times I got nauseous and spent a few hours throwing up.

My 2 cents.
 
Generally a bad idea, possibly a really bad one.

1) Seizure risk. Amphetamines are known to lower the seizure threshold, and tramadol is outright notorious for it.
2) Serotonin syndrome. Amphetamines are monoamine oxidase inhibitors, whereas tramadol also acts as a serotonin-noradrenaline reuptake inhibitor.
3) Even without the above, tramadol is generally a bit of an oddball and is a bad idea to combine with many drugs. Many of its side effects are also the exact opposite of what you'd want after stimulant use, at least for me.

Note that particularly after repeated dosing, you will subjectively feel that the effects have subsided, when the drug is still present and active in significant levels in your bloodstream - partly due to acute tolerance, you will no longer feel greatly stimulated. If the stimulants are well and truly over, you may not be at much risk but odds are you'll still feel a little uncomfortable, nauseous, tense or slightly spastic.

Also, the general consensus among people that I know and internet forums I've read is that you'll probably regret it.
 
definitely no! im glad someone answered you in time as there are many risks and contradictions to combining tramadol and stims such as increases risk of seizures, increased stimulation which could lead to cardiovascular issues
 
Please don't Tramadol has SNRI properties mixing with serotonic things may be dangerious - a real opiate insted but watch dosing.
 
^ Don't worry,i have no intention of.I am aware tramadol can be like walking on eggshells when combined it was more of a is it safe to take a day after,not combine question. I only really take for it's antidepressant lift. Best taken alone,well away from other drugs,although i have heard rumours it's potentiated with white grapefruit juice.
 
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Even though i am well aware of the dangers of doing this, out of desperation on amphet crashes i have actually done this. And, it does work. The SNRI properties of tramadol do pick you up from a stim crash. I am in no way condoning this by the way, its a very reckless thing to do. But hey, we've all been desperate sometimes right?
 
I was prescribed both at the same time and had a discussion with both my doc and pharmacist about this. Short answer shouldn't generaly be a problem, I neever had one; however, both amp and tramadol are 5-HT releasing agents, so technicaly 5-HT toxicity (Serotonin Syndrome) is possible. There has not been a recorded case of 5-HT toxicity with this combo or at least one that has been documented properly. That said if you decide to go that route it couldn't hurt to have a 5-HT antagonist like cyproheptadine on hand just in case..=D
 
Just for the record, I just tried this. It feels great. I know, I'm a hypocrite.
Still not the best idea, though.
 
Wel,l I am perscribed methadone, tramadol, and ritalin by a pain management specialist doctor, a regular doctor would be scarred to death to even give tram with meth. I have been doing this for twenty years and I am just fine. My specialist tells me if a reg Doctor calls Methadone a pain pill get up and walk out. They do not know what they are doing. Tramadol originaly was given to drug addits that have had surgery and needed pain meds. but scarred off getting hooked again. It use to say it was a non-narcod. pain pill. But they were wrong and have since made it a class 2. Tramadol is a great drug with a lot of benifits. I am told to take it with my methadone for break threw pain. When I have taken all the meth I can that day but, still in pain, i am told to take it with my ritalin when I am have a bad day with my narcolepsy, tram increases the bang in the ritalin and makes it last longer. The great side effects to this drug is the weight loss and the fact that it makes you naturaly produce seriton, which gives you the euph. But if you are not hard core with meth or stims do not do this !!! Methadone blocks the bang of other meds. so you do not know that you have done to much till it is way to late to do anything to save your life. Never go to sleep when you have taken meth and tram or tram and a stim unless you have been doing it for a couple of years and really know your body and it's limits !!
 
Im on Tramadol for pain relief, and I first tried speed today after 20 years or so. The tramadol im on is 200mg XR, I get about 50 mg tramadol per hour from one tablet over 4 hours.
Taking 2 lines of speed as a test for a later party, I felt no I'll effects. But the stim is wearing off now and im feeling a bit tired. That's about it.
I also take an ssri, called Mirtazapine nightly at 60mg, and apparently that's never supposed to be used with tramadol, so why all the docs I've been seeing for the last few years think its ok, I don't know.
But I've never felt anything bad except once or twice I got restless leg syndrome, when i accidentally took double the mirtazapine dose.


Just my experience, but I know from research and also the leaflets inside the pill boxes, that they are not to be mixed.
Perhaps im very resistant.?
So i wouldn't recommend it according to the lab reports but i can tell u the docs all think its ok, or not a high enough risk.
 
I hate "therex morphine in tramadol" I have heard this from 3 people. It's NOT morphine, it's very different.
 
In the dangerous drug combo thread, several posts are about tramadol + stimulant combos, including a fatality from snorting coke and tramadol.


Antagonistix said:
I also take an ssri, called Mirtazapine nightly at 60mg, and apparently that's never supposed to be used with tramadol, so why all the docs I've been seeing for the last few years think its ok, I don't know.
But I've never felt anything bad except once or twice I got restless leg syndrome, when i accidentally took double the mirtazapine dose.
Click to expand...

Just to let you know, mirtazapine is not an SSRI. It lacks any significant reuptake inhibitor effects for serotonin, norepinephrine, or dopamine. Knowing that, you should be careful if you mix tramadol with an SSRI. I have done it many times with sertraline/Zoloft and I have done it a few times with citalopram/Celexa.

Its usefulness as an antidepressant comes from its action as an antagonist/inverse agonist at various serotonin and alpha adrenergic receptors and through downstream modulation of the opioid receptor system, mainly mu-opiod and kappa-3 opioid receptors are involved.

I do not know what is meant by downstream modulation of a receptor system. If anyone knows, please either post it or let me know in a PM.
 
Tryptamine*Dreamer said:
In the dangerous drug combo thread, several posts are about tramadol + stimulant combos, including a fatality from snorting coke and tramadol.




Just to let you know, mirtazapine is not an SSRI. It lacks any significant reuptake inhibitor effects for serotonin, norepinephrine, or dopamine. Knowing that, you should be careful if you mix tramadol with an SSRI. I have done it many times with sertraline/Zoloft and I have done it a few times with citalopram/Celexa.

Its usefulness as an antidepressant comes from its action as an antagonist/inverse agonist at various serotonin and alpha adrenergic receptors and through downstream modulation of the opioid receptor system, mainly mu-opiod and kappa-3 opioid receptors are involved.

I do not know what is meant by downstream modulation of a receptor system. If anyone knows, please either post it or let me know in a PM.
Click to expand...

Hey TD,

I only found out about this yesterday when I was researching it.
BUT, its apparently very dangerous to mix tramadol with mirtazapine. It doesn't only state this in its own literature, but on many web articles I read. It can lead to Seratonin Syndrome, which i didn't know what it was before, but now I know, I've been close to that a couple of times and had to go to hospital cos i thought it was my other kidney issues, health issues causing me problems. I felt like a seizure or heart attack, but thankfully both times it happened to me, it lasted about 3 hours and I was ok ish again.

But mirtazapine is apparently one of the best antidepressants out there, and I was actually prescribed it to help me with codiene withdrawel, and u know what, I got zero withdrawel symptoms, only very mild ones. So it worked
But I've been on them for years now, and docs use it to stop me getting too depressed.
But since my research, I've halved my dose and I have no dea what I'll do for pain relief because currently im on tramadol. I need the pain relief cos I've had surgery recently, quite major ones.

Also worth to mention hat mirtazapine has anti anxiety properties and initially was very good at seating me and helped me sleep. But after years on it, I hardly feel any of those effects.

But i wouldn't risk mixing tramadol with anything that will induce serotonin syndrome, its bloody scary and yes it can creep up on you.
 
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