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  • BDD Moderators: Keif’ Richards

Tramadol and ADs

A

Allein

Bluelight Crew
Joined
Oct 29, 2005
Messages
10,940
I just got a strip of tramadol For free but I'm on Venalafaxine 150 XR but allso take about 50mgs of Diaz a day.

Is it OK to have a little dabble or is it a really stupid thing to do, don't often get freebies and have never tried tramadol
 
Tramadol is also an SNRI, so the risks of combining two SRI antidepressants is there...

I wouldn't risk it to be honest, I don't have much experience with venalafaxine, I would wait for somebody who has experience mixing the two chimes in here...
 
Rummaging around the net I kinda get the whole serorotonin syndrome thing, but surely an increase in my Venalafaxine intake could have the same effect or the addition or something like Amitriptyline, which my doc was only trying to get me to take the other week. The SNRI properties of Tramadol seem pretty weak in comparison, and the Diaz lowers the seizure risk so it all sounds good to me ?

I haven't done any yet in case some one someone forward with a good reason not to if not I may throw caution to the wind and drop a couple of 100 mgs ..an ambulance is only a phone call away ;)
 
I've never really found Tramadol to be recreational. Sure it helps my back pain and such, but it's not something I take for fun...
 
atm you're on point about the diazepam reducing the risk of seizure but it doesn't do anything in regards to the serotonin syndrome risks.

Since you seem to want to just do it anyway are you at least aware of the symptoms of serotonin syndrome?
 
Pjkt2501 said:
I've never really found Tramadol to be recreational. Sure it helps my back pain and such, but it's not something I take for fun...
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Tramadol is plenty recreational for a lot of people, myself included, and some people it doesn't do much for. That is not what this is about, though, so lets try to keep the posts on topic.

To answer the OP's question: Venalafaxine is not very safe at all to take with tramadol, the risk of serotonin syndrome skyrockets as well as the risk of a seizure. The seizure risk is much less if you're taking diazepam, but you are still going to need to be very careful if you're planning on mixing the two. They're really very structurally similar; venalafaxine is derived from tramadol, and they share a lot of the same characteristics.

My advice is to not take them at all, but if you're going to do it anyway it is important IMO that you slowly "ramp" or "stagger" your tramadol dosage up in 50mg intervals. You should of course start with a low dosage; I wouldn't go over 100mg until you get a feel for how it is going to make you feel, especially since you're on venalafaxine.

Tramadol is not a drug you just 'throw caution to the wind' with. It is very dangerous to mix with a lot of other drugs...it doesn't play well with others. Then again I've been unfortunate enough to experience how unpleasant tramadol seizures are, so I may be biased.

EDIT: Here is a thread on the subject.
 
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atm, I mixed them once and while I didn't get serotonin syndrome I felt extremely uncomfortable, it was very unpleasant - hot, jittery, nauseated, muscles tense.. was like a very minor serotonin syndrome really (its all a cointinuum) and it was horrible. I would strongly advise you not to mix the two I am afraid...
 
Oxide said:
Tramadol is plenty recreational for a lot of people, myself included, and some people it doesn't do much for. That is not what this is about, though, so lets try to keep the posts on topic.
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Sorry Oxide, what I was more alluding to is the point you went on to make:

Tramadol is not a drug you just 'throw caution to the wind' with. It is very dangerous to mix with a lot of other drugs...it doesn't play well with others. Then again I've been unfortunate enough to experience how unpleasant tramadol seizures are, so I may be biased.
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In that given how weak Tramadol is (if an appreciable level of enjoyment is gotten at all), it's not worth the potential risk / threat to life.

Didn't explain myself terribly well on that one.
 
I'm still no really sure I fully understand what serotonin syndrome really is from a medical point of view. I think I'm missing the point.

1.) The doc is quite happy to prescribe Amitriptyline I believe that would increase the levels of serotonin in my brain ...no ?

2.) many people are on multiple SSRIs

3.) when I jumped from 75mgs of venlafaxine to 150 wasn't there a risk then, if they decided I need 300 would that not represent another risk.

Sorry if the answers an elementary but I don't think I'm getting it at all.....still feel fine after 100mgs 1.5 hours ago, I know I shouldn't have but atm23 a bad boy:)
 
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In all honesty people worry too much about seretonin syndrome.

My doctor has been a doctor for 35 years and says he has not once seen a case of seretonin syndrome.
 
Well, I have... Wasn't pleasant for me or the person who was in that condition. Thank god it was just mild. (note - not trying to sound like a douche with the "yeah well, psh I have" comment)

(fuck sketch molly - but sorry that's VERY off-topic).
 
Tripman said:
In all honesty people worry too much about seretonin syndrome.

My doctor has been a doctor for 35 years and says he has not once seen a case of seretonin syndrome.
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I know 3 people who have had it and one who died of it.. One guy (a BLer, who didnt die thankfully) got it from tramadol and acid. He was really unwell..

The risk may be exaggerated but it is still present, low chance of getting it, high chance of dying if you do..

Info on serotonin syndrome atm. I can write more tomorrow, brain a bit hazy today...
 
Thanks Effie, still don't get why taking twice the dose of your existing SSRI or SNRI or whatever don't cause the same problem, in my simple world more SSRIs or drugs that end up giving you more serotonin floating abut in you brain = more serotonin therefore there is a risk of the syndrome, this is obviously wrong but I can't find out why.

It feels like its saying I can drink a half a bottle of vodka then drink another whole bottle of vodka (or indeed scotch ) and not get alcohol poisoning ??...obviously other alcoholic beverages are available ;)
 
TBH atm I do see your point and I am not entirely sure either! All I know is when I took it I had very unpleasant side effects which matched serotonin syndrome's symptoms only a LOT milder obv - there may well not be a risk, I am not sure. Usually it's a serotonin releaser and a reuptake inhibitor that are implicated.. so your brain is flooded with serotonin then it can't be reabsorbed, leading to dramatically elevated levels.
 
effie said:
TBH atm I do see your point and I am not entirely sure either! All I know is when I took it I had very unpleasant side effects which matched serotonin syndrome's symptoms only a LOT milder obv - there may well not be a risk, I am not sure. Usually it's a serotonin releaser and a reuptake inhibitor that are implicated.. so your brain is flooded with serotonin then it can't be reabsorbed, leading to dramatically elevated levels.
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Isn't that what MDMA does but without the re-uptake inhibitor action ?? I ended up doing 200mgs and was quite a pleasant kinda nod, irresponsible I know but that's me, possession = consumption.

Interested to understand more maybe we will find and expert tomorrow I'm off to bed, car bust so I've booked the day off to get it sorted
 
I'll have a gander in my psychopharmacology book for you when I less hazy-headed atm :)
 
^^^


Have you taken Tramadol, Diaz and Venlaxfain then?..or are you jut refering to the Tramadol ?

I did 200mgs of it in 2 doses last night along with about 40mgs of Diaz and had taken my normal 150XR Venlafaxine in the morning and really enjoyed it, it agave a really nice relaxed nod which lasted ages , I left a couple of hours between doses and did a little more Diaz with these second dose to be on the safer side.

I felt no ill effects and have fully abluted this morning with no problems, must be my tiger blood again;) me and Charlie are always in for a but of winning!
 
I'm just bumping this msybe it needs to go over to ADD, i thought I understood Serotonin syndrome but clearly not now I'ce started to devle a bit deeper.

I concise explanation of the actual mechanism would be very helpful
 
I think that such questions as for combining meds should be discussed with specialists, because following one's experience may be very dangerous for your health%)
 
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