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Toxicity of GHB

LD-50, and what will actually make you dead is very different..
just look at the LD-50 for MDMA, im POSITIVE you'll die before reaching the 1/2 way point.. maybe even the 1/10 way point. its something like 6000mg of MDMA.
id imagine high doses of GHB will supress breathing to a point where you could die.. granted, im sure they could hook you up to machines to breathe for you, and pump in more GHB and you wouldnt die from the actual GHB. people have died tho, and not from reaching toxic levels. theres other things to take into account when thinking "how much will kill me" besides the LD-50.
 
Very true, Funkay...the LD-50 is irrelevant. What is relevant is that the safety margin of GHB exceeds many OTC pharmaceuticals. Unfortunately, GHB is not very forgiving when it comes to mixing with other CNS depressants. It is, like you said, the other side effects that are the primary worry for GHB mishaps.
 
Originally posted by FunkayRavin:
LD-50, and what will actually make you dead is very different..

You fuckwit! Do you know what LD-50 is? It is the dose that kills 50% of the population! Idiot.
I don't give a shit if you are positive that somebody will die at half of the LD-50 or ten percent of the way. You know fuck all! I'll ask a scientist. Somebody who knows their arse from their elbow, which you clearly do not.
If you're a fucking idiot (and you clearly are) then just don't bother posting here.
Thank you. Drive through.
Harry
 
If you stick to medium recreational dose than GHB is non-toxic
If you stick to recreational dose of huffing gasoline, now that is toxic
GHB allthough technically non-toxic you should take care, i mean water can be deadly in huge amounts, but GHB in 10 grams....
 
I think its a bit like booze, I mean if you have a few pints every now and then then its fine and will cause you very little harm.
However if your knocking back 10 pints a day then it will bite you.
 
Also I'm not sure about GHB, but I nearly topped myself on GBL after taking 3.5ml. I dont know what the LD-50 is for that but I can clearly state my I know I nearly died, my wife had to shake me awake a few times because I'd fallen asleep and wasnt breathing.
 
So if G suspends dopamine while high, and releases a heavy amount on comedown,
does the high make you feel sleepy..? And do you feel like you're on Coke when you wake up..?
Can some one give me an accurate description of the hole G process...??
I'm considering using it moderately for workouts...
 
I'm considering using it moderately for workouts...
__________________________________________
you only need a very small amount 200mg for this the night after your workout to increase the amount of rem sleep and thus muscle cell growth (although i dont think this has been proven yet). The amount you need for a buzz is roughly 10x this amount 2grams (for me anyway)
 
A friend of mine used to get really blasted and go work out. He said it made lifting metal more entertaining. ;)
Damnit, I want some G now.
 
Actually getting to the real 'high' of GHB is easier said than done. The first time you try it you will, if you are lucky, get just a little nauseated, giddy, and your legs will heat up. You won't know if you feel great, or just slightly buzzed and nauseated, but it will feel ok.
If you take too much the first time, you will most likely never ever try it again. Suffice it to say that even a mild OD on GHB is one of the worst possible feelings. Imagine drowning and vomiting in overlapping intervals of a haze of unawareness, coupled with a feeling of constriction in your chest and a persistent feeling of nearly dying.
Something like that.
Now, if you poke around your ideal dose a few times, once each night, you will eventually hit the dose that induces a type of mental clarity and energy, while simultaneously heating up the legs, increasing tactile sensation and sex drive and sensuality, while providing a gentle undercurrent of well-being and relaxation. Mild opiate feeling in the body with a a sensory enhancement aspect. Tough to describe.
It is not like being drunk at all, despite what many people claim. If you feel drunk, you took too much to really get to the real deal high of this compound.
Scale it back. Don't get impatient with GHB, or you will pay a hefty price, believe me. GHB is a subtle high, folks.
Your dose will ALWAYS be your dose, as long as you allow yourself to return to baseline before redosing. If you overlap doses, you will GRADUALLY develop a tolerance, although this is not true in the clinical sense of the word.
In any event, for me the ideal dose is exactly 2.5 grams on an empty stomach. This, followed periodically by 1 gram redosings is ideal.
For sleep, 3 grams does the trick every single time without exception.
For deep fast knockout I take 3.5 grams.
Comedowns off MDMA require only 1.5 grams, about once every forty five minutes until I decide to call it quits and sleep, which is easily accomplished with a 3 gram dose as the final dose.
Four grams makes me very sick.
Its that close.
Hope this helps.
[ 14 December 2002: Message edited by: synchrojet ]
 
Ok i am only thinking out loud here, no medical experience.
Everybody is arguing about the level were GHB becomes lethal, many stating that it is an extremly high level. Eg. "However the LD50 is considerably higher than 10 grams"
That may be the point where the drug itself is what kills you (or 50% of the population) but what if, as is possible people suffer respritory failure on a much lower dose.
You then die of 'respritory failure', it may be a complication of the drug but you are still dead.
Just a thought, my opinion is don't fuck around with G. Why push it and find out ;)
 
Like alcohol, GHB can be EXTREMELY addictive, and heavy addicts (I've known a few in my day…) display withdrawal symptoms similar to delirium tremens. Now, it DOES take daily GHB use and redosing to get to this point, but it CAN and DOES happen.
As for toxicity, PURE GHB is nontoxic at a recreational dose AFAIK. I'm not so sure about all the shit available on the black market. After all, who knows how they synthed it, and if they purified it?
 
I never go more than a day on GHB. And that is always the day after I roll--to come down. I start with the 1.5, 2g, depending on how tweaked I feel underneath the roll. I wait until I actually feel the G wear off completely before redosing. Usually this takes about two hours. From there, I go about 1.5 every hour or so, maybe a bit longer. When I start to just feel tired and I know the show is over, I wait until everything wears off, then finish with a 3g dose.
That eases me into sleep pretty quickly.
BTW, I measure my doses with a syringe, every single time. Now, my G is not distilled at 30g/oz(impossible in liquid), I think it is about 27-28g/oz. My "3g dose" is a 3ml syringe filled completely, just past the 3ml mark.
My G (when I had it...I don't anymore because it is illegal), would solidify into a waxy substance at room temperature. I would have to hold the container in my warm hands for a bit, or lower it into warm water, in order to be able to draw it into the syringe.
I mention this as a reminder that not all G is distilled to maximum saturation, and therefore more ml might be required to achieve the same effects. Just be very very careful. As I stated, 4g makes me absolutely miserable, puking and passing out, the whole deal.
Be careful.
[ 16 December 2002: Message edited by: synchrojet ]
 
re: The LD50 & MDMA
Most ecstasy related ER visits and deaths fall to a few factors: dehydration, water intoxication, heart or liver failure. In each of these cases it would not have mattered if it was 1/4 of a pill or 50 pills taken. The overdose was taking ecstasy in the first place.
Check out the overdosing section.
Overdose & MDMA should not be used in the same sentence. There is little if any risk of an overdose in the same way there is with Alcohol, Heroin, Cocaine, Tranquilisors etc.
You are not at any less risk from death by taking less. However the neurotoxity risk is higher as you increase your dose and frequency.
Just wanted to make this clear, this is a dangerous ecstasy myth.
Jason.
 
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