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Toxic Psychedelic/Disassociative Combinations

thoughtsUnThought

thoughtsUnThought

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Joined
Apr 5, 2006
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925
searched, didn't find anything of this topic specifically...

What combinations of commonly used or more obscure psychedelics/disassociatives cause toxic reactions?? i know certain combos can cause serotonin syndrome, i'm curious of any other Big No nos to keep in my mental hall-of-records (for avoidance purposes of course lol)

i know that when i was younger i ate 600 morning glory seeds (Hb) and then split a bottle of robitussin (possibly with guafinessen) which caused me to fade out (almost like blacking out, but more trippy lol) and then wake up the next day puking. only to continue puking and laying in bed for rest of the days entirety. this definitely felt toxic on the body, far moreso than either of these alone.

does anyone know of pharmacological dangers of combining LSAs and DXM...??

that's my inspiration to start this, finding out the dxm lsa thing, but i think its worthwhile having a thread which serves as a red-flag for any such combos of danger.
 
Some psychedelics are thought to act as MAOIs to some extent, and mixing MAOIs with the Serotonin Reuptake Inhibitor dissociatives like DXM could also lead to serotonin syndrome, so that's a few you want to avoid. aMT is the only one I can name off the top of my head and that's a very weak reverse inhibitor so it's plausible it'd be safe - but definitely not something worth risking to find out.
 
jesus said:
Some psychedelics are thought to act as MAOIs to some extent, and mixing MAOIs with the Serotonin Reuptake Inhibitor dissociatives like DXM could also lead to serotonin syndrome, so that's a few you want to avoid. aMT is the only one I can name off the top of my head and that's a very weak reverse inhibitor so it's plausible it'd be safe - but definitely not something worth risking to find out.
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The 2c-t-x series have MAOI action, or at least some of the do.
 
Isn't the maoi action of 2c-t-x what makes the 2c-t- series a bit more dangerous then the normal 2c-x family?
 
Serotonin agonists (in this case LSA) and SSRIs (in this case DXM) should not be combined,

Dissociatives (i.e.NMDA channel blockers) and psychedelics (5-HT2a agonists) are an excellent combination, on the other hand. There is nothing in particular to contraindicate e.g. ketamine plus MDMA or psilocin, as long as you keep in mind that ketamine does increase blood pressure somewhat.
 
Would DXM and Magic Mushrooms be a safe combination? I have heard of quite a few people on the internet doing this.
 
thanks for the responses guys, exactly what i was looking for :D
especially with regards the the ssri action of dxm in conjunction with the serotonin agonist danger.

lol, figured there'd be some straight-forward science behind the toxicity of that combination. i never pushed the limits with combinations and i've only ever done psychedelics since i was introduced to them (lost interest in non-psychedelic intoxication). But when i was younger i definitely tried most-every combination of the substances in my repertoire. this dxm and MG experience was the only one that felt very physically toxic, and in retrospect there was a feint or 'passing out' sensation during the experience before i blacked out/drifted away (or something in between the two).

i'm curious now regarding the others i've experienced...you guys said mushrooms and dxm isn't toxic, right..? i did that 2 or 3 times on ~400mg dxm and and eighth of strong mushrooms, those were intensely other-worldy and unique (very dali-esque), but didn't feel physically toxic. what about LSD and DXM..?? don't mean to ask a stupid question, but does this have the same toxic interaction as with the LSAs in MG? I ate a hit of very strong acid ~200ug with DXM ~400mg on i believe 2 occasions as well...and those were very very intense and pretty 'dark' feeling, but i definitely didn't black out and puke the next day as i did with the LSAs. though, i definitely was on a much higher dose proportionately with the MG experience...lol 500-600 of those seeds were extremely overwhelming and visual without any dxm...rambunctious youth :)

i never mixed mescaline (san pedro/peruvian torch) with anything other than mushrooms. though I'm curious of the phenethylamine toxicity when combined with dxm. Also, i've heard that the core of the cactus contains MAOI compounds. if one was the juice a cactus..;) which i plan to..does this open the door to toxicity with regards to combinations which previously would have been safe..? or is the core of the cactus' maoi content more comparable to something commonly dismissed as benign like dark chocolates mild mao inhibiton..? i'm not going to combine it with dxm, i no longer work with that chemical, this is to fuel my understanding...! lay the neurochemistry/ human physiology on me :D
 
Also possibly a stupid question...Coffee, or caffeine....

any dangerous interactions with this and dxm or the reversible maois like amt. i ask because i've drank a pot of coffee while coming up on dxm, again when younger, and it feels pretty draining...lol, though very euphoric.

i'm not talking like a cup, more-so the questionability of decently high dose caffeine doses like 5-10 cups (i was a coffee twaker back then :))
 
thoughtsUnThought said:
Also possibly a stupid question...Coffee, or caffeine....

any dangerous interactions with this and dxm or the reversible maois like amt. i ask because i've drank a pot of coffee while coming up on dxm, again when younger, and it feels pretty draining...lol, though very euphoric.

i'm not talking like a cup, more-so the questionability of decently high dose caffeine doses like 5-10 cups (i was a coffee twaker back then :))
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Well, lots of caffeine with dxm is not recommended, it can increase hypertension and stuff, however 5-10 cups sounds very excessive and I'd say just don't do it for safety's sake.

It's outright contraindicated if you use white grapefruit juice or some other enzyme inhibitors to potentiate the DXM because they also inhibit CYP1A2 which is responsible for the metabolization of caffeine as well as a number of its active metabolites. Under these circumstances having even one cup of coffee should be avoided.
 
thanks for the feedback neverknowsbest,
and fear not, this information is my retrospective-mining for information. i did that combo a few times way back when, but i don't think i'll ever even consume dxm again.

the most dehydrated i've ever felt in my life was DXM + LSD + 5-8cups of coffee. lol, i could not re-hydrate myself, it was as though my whole body clenched up and rejected all water. after chugging glasses my mouth was still dry and i still felt woozy and desert-like.

goes to show, the only weird physical reactions i've had have been on the few times i accidently consumed a questionable combo8(

this post is mostly to make a flag for anyone new to psychedelics who's interested in a quick reference of no-no combos.

thanks guys..!
 
One saturday I decided to take 4-MEC during the day, 2C-E late in the afternoon, and MXE in the evening.

This proved too much and I experienced something I can only describe as a minor psychotic episode.

The experience is on my blog, and not something I care to experience again.
 
Mixing DXM with any serotonin releaser (MDMA, aMT, 5/6-APB, methylone/butylone/mephedrone/etc) or MAOI (2C-T-x) can cause serotonin syndrome; Don't combine DXM with those drugs, ever. For similar reasons, I would council against mixing DXM with any psychedelics - it may be okay (as some have attested to with DXM + mushrooms), but I've heard a few reports also of very worrisome reactions to such combinations.

DXM in general is really really unfriendly towards combinations, due to it's incredibly promiscuous binding profile. It's not the NMDA antagonism that causes the harmful interactions, it's the other effects (mainly that it's an SSRI) - other dissociatives are generally safe to combine with psychedelics and empathogens if you can handle the trip.

Dissociatives generally behave badly in combination with alcohol, though.
 
I mixed DXM and 25i-NBOMe last night. It was a great experience, however at one point there was some very troubling pressure feeling around my heart/chest area. Also a very intense comeup for the first 2 hours, probably in part due to mixing potentially dangerous substances. It's all in the name of science though ;)

dosages were -

dxm - 350mg in tussin syrup (bleh)
25i - 500ug buccally/sublingually
 
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