A big fan of MXE Kate i see. Never tried it but after my experience with ketamine i am guessing i would not like that one. I dont think dissasociatives are for me. Everyone who has had it seems to prefer it to K though. Why is that?
I think I can cover this one for you...
I've done a fair bit of both, along with a variety of other dissociatives, and I'd say ket and MXE are actually pretty different. The similarities are there with them both being NMDA antagonists and all, but all things considered there are as many (or more) differences than similarities.
I love ketamine, but comparatively it has a bit of a clinical feel - very anasthetic, wrecks your coordination, is very cognitively unfunctional; can sometimes kind of feel like someones whacked a basketball off your head and you're reeling from the shock - but an extremely extended version of that. By comparison, although MXE does have some of these traits to some degree they are a lot less characteristic of the drug.
I'd almost go as far as to say ket is to MXE as amphetamine is to MDMA/mephedrone in the stimulant and monamine releaser type of drug category. Ket is very good at dissociating, but MXE is also an enjoyable dissciative experience with lots of added bells and whistles that make it more exciting. It is more stimulating, and in conjunction with the excellent music appreciation it gives (compared to ket which sometimes makes music sound bland and worse even) makes it the best dance drug IMO, better than MDMA. It is very versatile though, and lower doses also go very well with watching films and appreciating art of all varieties. At these doses, it isn't hard to follow what is going on around you in the way ket can sometimes be.
In higher doses, and in regards to the trippy side of things, MXE is a much more colourful, visually interesting substance than K is. At high sub-hole doses (i.e. not OBE experiences), I have often had experiences that have felt like a spiritual orgasm, kind of like the "profound" button in the brain is getting pushed very hard and it can feel very magical and give the illusion that supernatural and extraordinary things are happening. The way it changes your thought pattern makes it the ultimate substance for philosophical musings and abstract thought. It also sometimes produces this strange feeling of "love", this isn't a consistent effect but when it does the best way I can describe it is heaven on earth.
I can also hole on it very easily, unlike ketamine. The holes are multitudinous in their variety and can take many forms, but they are always interesting and full on OBE. Often more classically psychedelic than the k hole, although they truly are a beast of their own. I'd say it rivals DMT in terms of interesting OBE potential, although DMT is much more consistent at producing this type of jaw dropping, "can't believe this is possible"-ness.
The antidepressant afterglow is also a lot stronger and longer lasting than k. I often felt so good on the days after that it was like being on another strong euphoric drug.
Generally, MXE is more euphoric, empathetic, social, psychedelic, magical..... you get the gist. Unfortunately it seems to have disappeared off the face of the earth at the moment, but if you ever get the chance to try it, leap on it. (Also, it takes a few trials before you start to appreciate the magic. It is one of these psychedelic(y) drugs that become more interesting the deeper you go.
MXE is by far the substance that has amazed me the most, and I've probably tried around 60 or more. It does have certain risks that aren't present with ketamine so obviously treat it with caution and respect. I know I don't need to tell someone with your knowledge and experience that, but for HR purposes it should be mentioned.
MXE is love, MXE is life
:D
EDIT: I know you are a fan of your DMT, MXE can be similarly profound and jaw dropping, albeit different way that seems somehow less wholesome. It is also incredibly fun and a bit hedonistic. Imagine a drug that kind of merges DMT and methamphetamine.... not as in it feels like a combo of those two (shudder at the thought of that), but it is an exceptionally successful combination of the two ideals. Obviously not nearly as hard on you as meth, that was not the purpose of the analogy.