when i did syrian rue i followed the diet for about 4 days before, and 1 day after. Everything was fine. Just be careful about the dose. 1st time i think i took 2 grams (a few years ago, could be wrong) Just barely noticed it. I doubled that a few weeks later and my whole world was one giant tracer, made me so sick. Had to keep my eyes closed most of the time or i got dizzy. Has potential in low doses in combo with other things, but be careful