All I can say is the research I have done makes me feel the numbers in my above post are about the average. Some people will claim they feel nothing from an 8 mg dose for 72 hours. Others say they don't feel much difference 24 hours after an 8 mg dose. I for one take 2 mg in morning and 2 mg late afternoon. Now I believe I metabolize faster than average, so when I want to use I wait until I wake up, 24 hours after 2mg and about 14 hours after the other 2 mg. I feel I can get at least 70-80% effects at that point and there is no blockade by the next day.
But for me I need to dose on Sub in the morning, I am useless and in moderate withdrawal without it. I hear other people who say they can skip their dose of Sub for a day and suffer hardly any issues. That may be cause they take a dose that hold above the ceiling effect for long enough or because they have slow metabolism. Just look at the half life listed for buprenorphine and you can see how it must vary greatly from person to person, because the half life is claimed to be 20-73, that is a huge variation.
