I would definatley take on an empty stomach or near empty. And possibly increase the dosage to 20-30mgs, only if you feel comfortable with that. My tolerance is too high to mess with vicodin. Percocet is better in my opinion. If your tolerance is low I would try to keep it there. I started on vicodin and percocet, loved the high. well I liked opiates too much and it led to heroin and other strong opiates. So watch how much you like it, try not to let it lead to worse things, good luck!