fake_blood96
Greenlighter
Hey everyone just trying to clear up some things regarding dopamine and serotonin releasing drugs and tolerance. So far it is my understanding that drugs like meth and cocaine cause the synapse to be flooded with more dopamine and obviously your brain doesn’t like this so it sets in motion downregulation of the dopamine receptors and increases the amount of enzymes that break down dopamine etc in order to keep the brain normal. So over time these dopamine releasing drugs will work less and less due to there being less dopamine in the brain from using the drugs and when there is dopamine there is also less receptors for it to bind to because of downregulation in order for us to get a good feeling from the drug.
Taking supplements like L-Tyrosine etc in order to replenish dopamine after a night out are good in that they help replenish the amount of dopamine in the brain to leave us feeling less like shit the following days after a big night out but continued use of l-tyrosine after a return to normalish levels of dopamine will not do anything to help with your tolerance to drugs like speed and cocaine because the brain will still be downregulating dopamine receptors due to excess dopamine produced from the l-tyrosine.
I’ve read that Seroquel will help in stopping tolerance because it blocks off dopamine receptors and your brain can try to upregulate again while you’re sleeping. Other drugs like Ketamine and MXE also can help with this?
All the above also applies to MDMA and the serotonin receptors in the same way I assume? Another thing being that serotonin replenishes at a much slower rate than dopamine but can be replenished much quicker with the help of 5-htp. I’m not sure if continued use of 5-htp will be beneficial in the upregulation of serotonin receptors to help decrease our tolerance to the drug like with l-tyrosine and dopamine receptors.
Please add to or correct me if I’m wrong on any of the above but also I have a few questions;
1: Is the amount of the dose or the frequency of use contributed with the downregulation of receptors, or is it both? Like I was thinking that ice being a potent and one of the most powerful drugs would definitely build up your tolerance to all other dopamine releasing drugs quicker than say your standard amphetamine sulphate would?
2: Also is it completely person dependant on how quickly your body becomes sensitive to these drugs again after abstinence?
3: Would sticking to GHB, Ketamine and Cannabis be ideal if I was to use drugs whilst giving my body time to resensitise itself to drugs like speed, cocaine and mdma as they don’t affect dopamine and serotonin?
Thanks for your help
Taking supplements like L-Tyrosine etc in order to replenish dopamine after a night out are good in that they help replenish the amount of dopamine in the brain to leave us feeling less like shit the following days after a big night out but continued use of l-tyrosine after a return to normalish levels of dopamine will not do anything to help with your tolerance to drugs like speed and cocaine because the brain will still be downregulating dopamine receptors due to excess dopamine produced from the l-tyrosine.
I’ve read that Seroquel will help in stopping tolerance because it blocks off dopamine receptors and your brain can try to upregulate again while you’re sleeping. Other drugs like Ketamine and MXE also can help with this?
All the above also applies to MDMA and the serotonin receptors in the same way I assume? Another thing being that serotonin replenishes at a much slower rate than dopamine but can be replenished much quicker with the help of 5-htp. I’m not sure if continued use of 5-htp will be beneficial in the upregulation of serotonin receptors to help decrease our tolerance to the drug like with l-tyrosine and dopamine receptors.
Please add to or correct me if I’m wrong on any of the above but also I have a few questions;
1: Is the amount of the dose or the frequency of use contributed with the downregulation of receptors, or is it both? Like I was thinking that ice being a potent and one of the most powerful drugs would definitely build up your tolerance to all other dopamine releasing drugs quicker than say your standard amphetamine sulphate would?
2: Also is it completely person dependant on how quickly your body becomes sensitive to these drugs again after abstinence?
3: Would sticking to GHB, Ketamine and Cannabis be ideal if I was to use drugs whilst giving my body time to resensitise itself to drugs like speed, cocaine and mdma as they don’t affect dopamine and serotonin?
Thanks for your help
