Ethnobotanicals Tincture madness

[placebonaut]

@Allylbenzene sent me off down another rabbit hole looking at trad tinctures, yes i know pills and other option but i found supplier in the uk with a lot of tinctures for sale, so here we are....

AI summary of the main ones that are psychoactive , both western and Chinese tinctures covered.

the toxic ones are a bit of a concern.....though I guess lots of things are toxic!

Tincture Name​

Botanical Name​

Effect Ranking (1=strongest)​

Effect Sub-Class​

Primary Class​

Psychoactive Status​

Reported Effects​

Active Compounds​

Mechanism / Pharmacological Action​

Receptors / Targets (where available)​

Evidence / Confidence​

Neurotransmitter System​

Effect Direction / Action​

Onset / Duration Notes​

Safety Risk Score​

Experience Profile Group​

Subjective Effect Intensity Score (1-5)​

Evidence Strength Score (1-5)​

Safety Score (1-5)​

Confidence Score (1-5)​

Research Priority Ranking​

Henbane herb tincture​

Hyoscyamus niger​

1​

Deliriant / anticholinergic​

Toxic neuroactive​

High​

Hallucinations, confusion, delirium; toxic rather than desirable psychoactivity​

Scopolamine, hyoscyamine, atropine​

Muscarinic acetylcholine blockade​

Muscarinic receptors (central M1 prominent)​

High​

Acetylcholine​

Muscarinic antagonist​

Rapid CNS effects possible​

5 - Very High​

Deliriant / toxic altered state​

5​

5​

5​

4​

3​

Monkshood root tincture​

Aconitum napellus​

2​

Neurotoxic / sodium-channel active​

Toxic neuroactive​

High​

Numbness, tingling, neurological toxicity​

Aconitine alkaloids​

Persistent sodium-channel activation​

Voltage-gated sodium channels​

High​

Ion channels​

Persistent sodium channel activation​

Rapid toxicity possible​

5 - Very High​

Neurotoxic / toxic altered state​

5​

5​

5​

4​

4​

Yellow Jasmine root tincture​

Gelsemium sempervirens​

3​

Toxic sedative-like neuroactive​

Toxic neuroactive​

High​

CNS depression, weakness, dizziness​

Gelsemine and related alkaloids​

Modulation of neuronal excitability​

GABA/glycine-related effects proposed​

Moderate​

GABA/glycine related​

Modulation of inhibitory signalling​

Variable​

5 - Very High​

Toxic sedative-like​

5​

4​

5​

4​

2​

Blue Lotus flower tincture​

Nymphaea caerulea​

6​

Sedative / euphoric anecdotal​

Anecdotal psychoactive​

Moderate (anecdotal)​

Relaxation, mood elevation, dream-like reports​

Apomorphine-related compounds reported; uncertain​

Proposed dopaminergic/serotonergic activity​

Dopamine/serotonin hypotheses​

Low–Moderate​

Dopamine / serotonin (proposed)​

Proposed receptor/monoamine modulation; evidence limited​

Unknown / variable​

3 - Moderate​

Anecdotal euphoric / sedative​

4​

1​

3​

2​

1​

California poppy tincture​

Eschscholzia californica​

10​

Sedative / hypnotic​

Calming​

Moderate​

Relaxation and sleepiness​

Benzylisoquinoline alkaloids​

Sedative pharmacology​

GABA-related mechanisms proposed​

Moderate​

GABA-related​

Sedative pathway modulation proposed​

Gradual / variable​

2 - Moderate​

Sedative / hypnotic​

4​

3​

​

3​

6​

Cola Nut tincture​

Cola nitida​

5​

Stimulant​

Stimulant​

Moderate​

Alertness and energy​

Caffeine and methylxanthines​

CNS stimulation​

Adenosine receptors​

High​

Adenosine​

Adenosine receptor antagonist​

Fast stimulant onset​

2 - Moderate​

Stimulant / alertness​

4​

5​

​

4​

9​

Green Tea Sencha tincture​

Camellia sinensis​

7​

Stimulant / calm focus​

Stimulant​

Moderate​

Alertness, focus, calm stimulation​

Caffeine, L-theanine, catechins​

Adenosine blockade; theanine neurotransmitter effects​

A1/A2A adenosine; glutamate/GABA proposed​

High​

Adenosine / glutamate / GABA​

Adenosine antagonism; theanine modulation​

Fast caffeine; slower calming effects​

1 - Low​

Calm stimulant / focus​

4​

5​

​

4​

10​

Guarana seed tincture​

Paullinia cupana​

4​

Stimulant / alertness​

Stimulant​

Moderate​

Energy, focus, alertness​

Caffeine, theobromine​

Adenosine antagonism​

A1/A2A adenosine receptors​

High​

Adenosine​

Adenosine receptor antagonist​

Fast stimulant onset​

2 - Moderate​

Stimulant / alertness​

4​

5​

​

4​

8​

Lobelia herb tincture​

Lobelia inflata​

9​

Nicotinic cholinergic​

CNS-active​

Moderate​

Stimulation, dizziness, nausea​

Lobeline​

Nicotinic receptor interaction​

Nicotinic acetylcholine receptors​

Moderate​

Acetylcholine​

Nicotinic receptor interaction​

Variable​

3 - Moderate-High​

Nicotinic-like CNS effects​

4​

3​

4​

3​

5​

Yerba Mate tincture​

Ilex paraguariensis​

8​

Stimulant​

Stimulant​

Moderate​

Energy and alertness​

Caffeine, theobromine​

Adenosine antagonism​

A1/A2A adenosine​

High​

Adenosine​

Adenosine receptor antagonist​

Fast stimulant onset​

2 - Moderate​

Stimulant / alertness​

4​

5​

​

4​

11​

Gou Teng​

Uncaria rhynchophylla​

14​

CNS calming​

CNS-active​

Low–Moderate​

Reduced agitation and calming​

Rhynchophylline alkaloids​

Neuroprotective CNS modulation​

Ion channels and neurotransmitter systems​

Moderate​

Multiple CNS systems​

Neuropharmacological modulation​

Unknown / variable​

2 - Moderate​

CNS calming​

3​

3​

​

3​

14​

Passion flower herb tincture​

Passiflora incarnata​

13​

Anxiolytic / sedative​

Calming​

Low–Moderate​

Relaxation, reduced anxiety, sleep support​

Flavonoids including chrysin/apigenin-related compounds​

Inhibitory signalling modulation​

GABA-A interaction proposed​

Moderate​

GABA​

GABA-A modulation proposed​

Gradual calming effect​

2 - Moderate​

Anxiolytic / sedative​

3​

3​

2​

3​

12​

Ren Shen / Ginseng​

Panax ginseng​

19​

Adaptogen / cognitive​

Adaptogen​

Low–Moderate​

Energy, focus, stress resilience​

Ginsenosides​

Stress pathway modulation​

NMDA/GABA/cholinergic systems​

High​

Glutamate / GABA / acetylcholine​

Multiple signalling effects​

Gradual adaptogenic​

2 - Moderate​

Adaptogen / cognition​

3​

5​

​

4​

23​

Shi Chang Pu​

Acorus tatarinowii​

17​

Cognitive / CNS-active​

CNS-active​

Moderate​

Mental clarity; traditional calming​

Asarones and volatile oils​

Neurotransmitter modulation​

GABA/glutamate proposed​

Moderate​

GABA / glutamate​

Neurotransmitter modulation proposed​

Variable​

3 - Moderate​

CNS-active / cognition​

3​

3​

4​

3​

17​

Suan Zao Ren​

Ziziphus jujuba var. spinosa​

11​

Sedative / sleep support​

Calming​

Low–Moderate​

Relaxation and sleep support​

Jujubosides, spinosin​

Sleep-promoting pathways​

GABA/serotonin pathways proposed​

Moderate​

GABA / serotonin​

Modulation proposed​

Gradual sleep support​

2 - Moderate​

Sedative / sleep​

3​

3​

​

3​

13​

Tian Ma​

Gastrodia elata​

18​

Neurological calming​

CNS-modulating​

Low–Moderate​

Reduced tension and neurological symptoms​

Gastrodin​

Neuroprotective modulation​

GABA/glutamate pathways proposed​

Moderate​

GABA / glutamate​

Excitability modulation​

Gradual​

2 - Moderate​

Neurological calming​

3​

3​

​

3​

18​

Valerian root tincture​

Valeriana officinalis​

12​

Sedative / sleep support​

Calming​

Low–Moderate​

Sleepiness and relaxation​

Valerenic acid​

GABAergic modulation​

GABA-A receptors​

High​

GABA​

Positive modulation of GABA-A signalling​

Gradual sedative effect​

2 - Moderate​

Sedative / sleep​

3​

4​

2​

4​

21​

Wild Lettuce leaf tincture​

Lactuca virosa​

36​

Sedative traditional​

Calming​

Low–Moderate​

Drowsiness and relaxation reports​

Lactucarium constituents​

Sedative-like traditional effects​

Limited receptor data​

Low–Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

3​

2​

​

2​

7​

Yan Hu Suo​

Corydalis yanhusuo​

15​

Analgesic / CNS-active​

CNS-active​

Low–Moderate​

Relaxation and analgesia​

Tetrahydropalmatine and alkaloids​

Dopaminergic and CNS modulation​

Dopamine-related targets proposed​

Moderate​

Dopamine / other CNS systems​

CNS modulation​

Variable​

3 - Moderate​

Analgesic / CNS-active​

3​

3​

​

3​

15​

Yuan Zhi​

Polygala tenuifolia​

16​

Nootropic / calming​

CNS-modulating​

Low–Moderate​

Calmness, memory support​

Tenuifolin, saponins​

Neuroprotective pathways​

GABA/glutamate proposed​

Moderate​

GABA / glutamate​

Pathway modulation proposed​

Variable​

2 - Moderate​

Nootropic / calming​

3​

3​

​

3​

16​

Ashwagandha root tincture​

Withania somnifera​

22​

Adaptogen / anxiolytic​

Adaptogen​

Low–Moderate​

Stress reduction, calmness, sleep support​

Withanolides​

Stress-axis modulation​

GABAergic effects proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

26​

Chamomile German tincture​

Matricaria recutita​

27​

Sedative​

Calming​

Low​

Relaxation and sleep support​

Apigenin, flavonoids​

GABAergic modulation​

GABA-A proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

31​

Chamomile Roman tincture​

Anthemis nobilis​

28​

Sedative​

Calming​

Low​

Relaxation​

Volatile oils, flavonoids​

Calming pathways​

Limited receptor data​

Low–Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

2​

​

2​

22​

Damiana leaf tincture​

Turnera diffusa​

35​

Mood / relaxation​

Traditional CNS-associated​

Low–Moderate​

Relaxation and traditional aphrodisiac reports​

Flavonoids, terpenes​

Limited CNS evidence​

Limited receptor data​

Low–Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

1​

​

2​

20​

Gotu Kola herb tincture​

Centella asiatica​

21​

Nootropic / anxiolytic​

Adaptogen​

Low​

Calm focus, memory support​

Asiaticosides, triterpenes​

Neuroprotective pathways​

GABA-related effects proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

25​

Hops strobile tincture​

Humulus lupulus​

25​

Sedative​

Calming​

Low–Moderate​

Sleepiness and relaxation​

Bitter acids, flavonoids​

Sedative pathways​

GABA-related proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

29​

Lavender flower tincture​

Lavandula officinalis​

26​

Anxiolytic​

Calming​

Low​

Relaxation​

Linalool, essential oils​

Aromatic CNS modulation​

GABA-related proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

30​

Lemon Balm leaf tincture​

Melissa officinalis​

23​

Calming / cognitive​

Calming​

Low​

Relaxation and calm focus​

Rosmarinic acid, volatile oils​

Cholinergic/GABA-related effects​

GABA-related targets proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

27​

Ling Zhi​

Ganoderma lucidum​

20​

Adaptogen / calming​

Adaptogen​

Low​

Stress support and relaxation​

Triterpenes, polysaccharides​

Immune and stress modulation​

Not clearly receptor-specific​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

24​

Mugwort herb tincture​

Artemisia vulgaris​

29​

Dream-related / traditional​

Traditional CNS-associated​

Low–Moderate​

Dream-related anecdotal reports​

Essential oils, flavonoids​

Limited CNS evidence​

Not established​

Low​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

1​

​

2​

19​

Siberian Ginseng root tincture​

Eleutherococcus senticosus​

34​

Adaptogen​

Adaptogen​

Low​

Fatigue reduction and stress support​

Eleutherosides​

Stress response modulation​

Not receptor-specific​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

32​

Skullcap herb tincture​

Scutellaria lateriflora​

24​

Anxiolytic​

Calming​

Low–Moderate​

Relaxation and sleep support​

Baicalin-related flavonoids​

Inhibitory signalling modulation​

GABA-A proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

2​

3​

​

3​

28​

Bacopa leaf tincture​

Bacopa monnieri​

32​

Nootropic​

Cognitive​

Low​

Memory support​

Bacosides​

Neuroprotective signalling​

Cholinergic pathways proposed​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

1​

3​

​

3​

35​

Catnip herb tincture​

Nepeta cataria​

30​

Mild calming​

Calming​

Low​

Relaxation​

Nepetalactone, volatile oils​

Traditional calming effects​

Limited receptor data​

Low​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

1​

2​

​

2​

33​

Cordyceps tincture​

Cordyceps sinensis​

33​

Adaptogen​

Adaptogen​

Low​

Energy and endurance support​

Cordycepin, polysaccharides​

Metabolic/immune modulation​

Not receptor-specific​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

1​

3​

​

3​

36​

Lion's Mane Mushroom tincture​

Hericium erinaceus​

31​

Nootropic​

Cognitive​

Low​

Cognitive and mood support​

Hericenones, erinacines​

Neurotrophic signalling​

NGF-related pathways​

Moderate​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

Not available / not yet reviewed​

1​

3​

​

3​

34​

Score	Subjective Intensity
1	Minimal/none
2	Mild
3	Moderate
4	Strong
5	Very strong / marked
Evidence Strength	1 = anecdotal/very limited; 5 = strong human/established pharmacology
Safety Score	1 = relatively low concern; 5 = very high concern/toxicological significance
Confidence Score	Overall confidence in the classification, not strength of effect
Research Priority	Higher priority = stronger apparent effect combined with weaker/less complete evidence
Field	How missing data is handled
Neurotransmitter System	Filled only where supported by the current workbook; otherwise 'Not available / not yet reviewed'.
Effect Direction / Action	Filled where an action is supported; otherwise marked unavailable.
Onset / Duration Notes	Filled only where the current data support a reasonable note; otherwise marked unavailable.
Safety Risk Score	Not invented where absent; marked unavailable / not yet reviewed.
Experience Profile Group	Filled where the existing effect classification supports a group; otherwise marked unavailable.
Important	The absence of a field value is explicitly represented rather than silently omitted.

 

[M!$TER-ED]

Excellent information....thanks very much appreciated