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tiletamine

Oh, good, Seiko... TCM! That was it, not Tiletamine. I should have paid closer attention. N-methylated Tiletamine analog.

So I retract my statement that I've ever had Tiletamine. It was apparently TCM of high purity. If Tiletamine is anything like TCM I still wouldn't touch it with a 10 footer.
 
I've done quite a lot of PCP analogs and one thing I can say about tiletamine is that it's truly a devil inside. Not much to talk about really. I would pick ketamine anyday over it. But this 20mg i.m. max dosing is not really true. I could do even 2ml of Telazol i.m. and there's 50mg of zolazepam in addition (but I've got a high tolerance to benzodiazepines and back then I had even higher, besides I thought zolazepam would diminish the subjective feeling of the bodyload, it's like twice to thrice less potent than clonazepam). The bad part about that was I simply blacked out in the toilet in my faculty...:|
 
GC/MS testing is the only way I think. There's no "fast and easy" test and colour/taste is certainly not enough to discern the two.
 
It should be. Here's a neat thread about a related compound, MPCH.

Here is a "family photo" for those interested.
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sekio said:
GC/MS testing is the only way I think. There's no "fast and easy" test and colour/taste is certainly not enough to discern the two.
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That's unfortunate. I don't know if I have tiletamine or just don't really like methoxetamine! :\
 
The effects of methoxetamine and tiletamine are very different if you compare two dissociatives. Actually, tiletamine may be seen as a really true dissociative because this is what you mainly feel. There's little euphoria if any (or if not dysphoria), you feel really disconnected, confused a lot, and there's a lot of locomotor dysfunction. And methoxetamine is warm, fuzzy, with not so much disorientation and you can control yourself much easier even if the dose is higher. It's nowhere near the hole you can get into while on tiletamine.

I'm not saying you definitely cannot enjoy tiletamine but it's a hell of a dissociative and even ketamine producing a K-Hole is different and produces a distinct form of euphoria. For me tiletamine feels like NMDA blocker mostly with sigma agonism and other ketamine actions almost absent. Nonetheless, PCE may also be considered a hard-on-the-body dissociative and still it may be found as a great dissociative.

One thing is sure, if you have taken lab grade methoxetamine and tiletamine, there's no way you confuse these drugs, they are so different. I regret that I didn't test both drugs with at least Marquis reagent but now I have neither of these two.:\ I just didn't feel the need to do this because the drugs were tested with mass spectrometry to determine lab grade purity.

- - - - -

I just wanted to add something concerning deschloroketamine. I've compared ortho-chloro with ortho-methoxy and it seems that the more the group withdraws electrons, the less psychotropic effects. But the other thing is how big the group at ortho position is because if there was some big atom there, it would change the shape of the molecule...
 
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Well it seems to me tiletamine would be like a less dopaminergic version of angel dust which sounds ok to me as I've liked pcp(used to luv it infact). However as of late I've stopped pcp a while ago but even my other favs like K,MXE, and DXM have all had a bizarre and eextremely scary effect on me. They'd make me blackout and instead of being stuck in a hole I would more than compitantly walk around and do something very specific... flush my chems! I mean I can't say for sure this is what I'm doing but id'd like be sitting on my bed and then while it seems like 30secs have passed my roomate would say I was walking around with a weird look on my face on then oddly something would be missing like say 10g of drone or grams of 5meoMiPT, 2cp, then ultimately after several of these instances my 1pz of MXE vanished. My roomate btw isa lady who has no use of knowledge of what powders r. Which nor does she mind that I have them so its not her. Even powders I've tried cleverly hiding from myself are not safe, I've even made a whole dufflebag fulll of some powdersb,important receipts and electronics vanish without a trace. I've literally lost thousands of dollars even tho I was never trying to get in a hole in the 1st place, I just enjoy the bodyhigh now

Anyway, as self destructive as they seem to be for me now as like a form of possession in that I have 0 control over my actions they still interest me. I'd like to see a combo of tiletamine and methoxetamine, I think it makes perfect sence: 2-oxo-3-Methoxy-thienylcyclohexylethylamine
 
(zonk) said:
Well it seems to me tiletamine would be like a less dopaminergic version of angel dust which sounds ok to me as I've liked pcp(used to luv it infact). However as of late I've stopped pcp a while ago but even my other favs like K,MXE, and DXM have all had a bizarre and eextremely scary effect on me. They'd make me blackout and instead of being stuck in a hole I would more than compitantly walk around and do something very specific... flush my chems! I mean I can't say for sure this is what I'm doing but id'd like be sitting on my bed and then while it seems like 30secs have passed my roomate would say I was walking around with a weird look on my face on then oddly something would be missing like say 10g of drone or grams of 5meoMiPT, 2cp, then ultimately after several of these instances my 1pz of MXE vanished. My roomate btw isa lady who has no use of knowledge of what powders r. Which nor does she mind that I have them so its not her. Even powders I've tried cleverly hiding from myself are not safe, I've even made a whole dufflebag fulll of some powdersb,important receipts and electronics vanish without a trace. I've literally lost thousands of dollars even tho I was never trying to get in a hole in the 1st place, I just enjoy the bodyhigh now

Anyway, as self destructive as they seem to be for me now as like a form of possession in that I have 0 control over my actions they still interest me. I'd like to see a combo of tiletamine and methoxetamine, I think it makes perfect sence: 2-oxo-3-Methoxy-thienylcyclohexylethylamine
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After thousands of dollars lost to this bizarre behavior, why not attempt to document the phenomena with a video camera (assuming your dissociative alter-ego did not run off with this as well)? While I can understand perhaps a compulsion to flush the missing compounds during periods of prolonged intoxication, I find it harder to understand the "I flushed my DVD player down the toilet" behavior". Perhaps........who never had a roommate to begin with......(ie, you are your roommate).

And if '1pz' means one "ounce" of methoxetamine (or variant), I am somewhat less surprised......(equally amused, though).....
 
Yeah its 1oz(typo), and this idea I've had, I wanted to wire the apartment with security cameras in every room but that would involve buying the cameras and a stationary computer they'd record to which after all the flushing or vanisshing or whatever is a bit difficult for me to afford at the mo', not mention that everyone of these instances was totally unintentional as I try to avoid holes. I should try some racetams mixed next time...
 
It'd definitely be hard if every time you set up your security system and then did some drugs, you flushed it all literally down the toilet.

Picturing you with a blank look stumbling around pulling security cameras down and then shoving them in toilets is a pretty funny image though.
 
ungelesene_bettlek said:
since there are people experienced with tiletamine in this thread: can you please give a short comment regarding dosage and duration?
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~3-4 times as strong as ketamine on a mg basis (same salt used, hydrochloride), with i.m. injection an onset within 1-2 minutes, the main effects last anywhere from 1 to 1.5 hour and it wears off within around next 4 hours. It's a definitely overwhelming dissociative at doses higher than "regular" and there's not that "refreshing" feeling after getting out of the Hole ketamine had always delivered me.

If you take a medium dose, you may get much more from it than if you make yourself deep into the Hole IME.

BTW, be careful with powder you get after vaporizing water from medications containing zolazepam or xylazine. Zolazepam is only about 1/3 as strong as clonazepam and there's 250mg in one Telazol vial. And xylazine acts like clonidine which is sometimes used in opioid withdrawal to reduce anxiety. A combination of a dissociative with an a2 agonist may easily take you away forever.
 
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sekio said:
It'd definitely be hard if every time you set up your security system and then did some drugs, you flushed it all literally down the toilet.

Picturing you with a blank look stumbling around pulling security cameras down and then shoving them in toilets is a pretty funny image though.
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LOL, good point, I go thru all the trouble of setting it up, accidently slip into a hole and come to as if nothing ever happened(as usual)only to find my computer/security system is missing w/o a trace
 
What if one could get access to the tiletamine alone without the benzos/zolazepam?

Would the experience be more ketamine like?
 
Well, since I'm moving to Iceland in January and already have 99% of my Stash over there... I figure I have time to do 2 or maybe 3 more trips on this continent before I go full viking...
One thing I didn't bother sneaking over there was my small amount of Lab tested Tiletamine so I have the house to myself tonight and thought I'd give a 40mg rectal admin a shot and see if it's a worthy disso....I could obtain more before I move but I'm resolved to not buy anymore RC's or drugs of any kind and I don't really want to roll the dice trying to smuggle anymore shit into fucking Iceland....they aren't the most understanding country when it cones to psychoactive substances!
But I will report back on how this trip goes....my go to dose of O-PCE is 50mg and the Bluelighter Asante has spoken quite fondly of O-TCE.
And I regard his experience reports with high regard.
Off to the races comrades......
 
sekio said:
Here's the facts as far as I can divine them.

Tiletamine is not used in "pure" form like ketamine is, so "diverted tiletamine" is mostly or entirely zoletile (50mg/ml each of tiletamine and zolazepam, Telazol) which has a much different qualitative response than plain arylcyclohexylamines (I think). Zoletile interferes much less with serotonin SERT/5-HT2a and dopaminergic DAT/D2 receptors when compared to ketamine/xylazine. (ref:http://www.ncbi.nlm.nih.gov/pubmed/12715241 - In layman's terms, this means TLE is much closer to a "pure dissociative" like mk-801 with less fun/magical/enlightening/euphoric activity.)


http://www.ncbi.nlm.nih.gov/pubmed/1847186

Tiletamine is more potent than MK-801 or ketamine at inhibiting calcium channel activity. (http://www.ncbi.nlm.nih.gov/pubmed/1338108)

Doses are typically "comparable to ketamine" if you're using it for anesthetia, but Erowid experiences suggest it's 3-4x as potent as ketamine, and doses start at ~5mg IM, possibly as high as 20mg IM. (well, starting with 5mg of each til and zolazepam, or 0.1ml Telazol) I cannot find a good figure for the half life of the compound, but it's similar to MXE (~2x longer than K). Since abuse is mostly by veterinarians from diverted Telazol there are very few "clean" tiletamine experiences. I did see it being sold on the UK "research chemical" scene but I trust that shit about as far as I can throw it. The few Erowid experiences with tiletamine also suggest that it's not very pleasant at all.

A semi-related drug, TCM (thienyl cyclohexyl methylamine), was known to be sold as "MXE". Someone tested it via GC/MS and found that the compound was likely TCM in high purity. I think it's more likely that other freakish drugs like TCM are being sold as MXE or used to curt MXE, rather than tiletamine - if you're going so far as to make tiletamine you may well be making MXE.

Metabolism of the thienyl compounds to thiones (thioketones) is one route of elimination, oxidisation of the amine might be another, glucuronidation and hydroxylation like with ketamine is another possiblity.

re: MXE, It's my personal belief that MXE has very small or insignificant affinity for the mu-opioid receptor. I think it does have considerable activity at dopamine DAT and d2/d3 receptors due to the 3-methoxy addition. (evidence for this includes mood lifts, compulsive usage, euphoria/mania, strong stimulation in some.) Perhaps it is also 4' hydroxylated in vivo, like with PCP? Compared to tiletamine, MXE is definitely preferable to some extent simply because it is more pleasurable.
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thank you, I was aware of some mentions but not Tiletamine. So you'd think that like ketamine might after all be something in its own realm? Always more potent doesn't give it any edge, I dunno if yin-yang terms should apply to drugs but fuck, we as humans in vocabulary haven't arrived there yet maybe in like 200yrs or so but even then. Me to say, I think ketamine has is own bloodline legacy regarding proved time-bend space on a "Uncompressing the archive" luxury.
 
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